DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brat and Nhlrc1

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_954706.1	Gene:	Nhlrc1 / 364682	RGDID:	735081	Length:	396	Species:	Rattus norvegicus

Alignment Length:	330	Identity:	75/330 - (22%)
Similarity:	129/330 - (39%)	Gaps:	69/330 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   746 KLLSATIYPPKSQIKRQK------MIYHCKFGEFGVMEGQFTEPSGVAVNAQND-IIVADTNNHR 803
            :||.:|::...:.:....      ..||. ||.:|.:    ..|:|:|:..:.. ::|......|
  Rat    88 ELLGSTLHASPAALSAASCAPGALTCYHA-FGGWGTL----VNPTGLALCPKTGRVVVVHDGKRR 147

  Fly   804 IQIFDKEGRFKFQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYG-------- 860
            ::|||..|....||||.|.....:.||..|||. |...::||:.... .:::::.:|
  Rat   148 VKIFDSGGGGAHQFGEKGDAAHDVKYPLDVAVT-NDCHVVVTDAGDC-SLKVFDFFGQIKLVVGK 210

  Fly   861 QFVRKFGATILQHPRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKF-GCSKHLEFPNGV---- 920
            ||...:|..|..| .||.|.:      .|...:.::..|....||.:. ....||..|.||
  Rat   211 QFSLPWGVEITPH-NGVLVTD------AEAGTLHLLEADFPEGVLRRIERLQAHLCNPRGVAVSW 268

  Fly   921 ------VVNDKQEIFISDNRAHCVKVFNYEGQYLRQIGGEGIT-NYP-----IGVGINSNGEILI 973
                  |:.....:..|......|||||...|.:.|:...|:. .:|     ..|..:..|.:::
  Rat   269 LTGAIAVLEHPCALGTSSGNNTRVKVFNSSMQLIGQVDSFGLNLLFPSKITASAVTFDHQGNVIV 333

  Fly   974 ADNHNNFNLTIFTQDGQLI---------SALESKVKHAQCFDVALM---DDGSVVLASKDYRLYI 1026
            ||.           .|..|         .||:..|.|.....|||:   ::..:||.|..:.:.:
  Rat   334 ADT-----------SGPAIVCLGKPEEFPALKPMVTHGLSRPVALVFTKENSLLVLDSASHSIKV 387

  Fly  1027 YRYVQ 1031
            ::.::
  Rat   388 FKVME 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662
		zf-B_box	328..366	CDD:279037
		NHL_brat_like	760..1030	CDD:271329	72/313 (23%)
		NHL repeat	783..819	CDD:271329	11/36 (31%)
		NHL repeat	830..871	CDD:271329	11/48 (23%)
		NHL repeat	874..910	CDD:271329	7/36 (19%)
		NHL repeat	914..954	CDD:271329	13/49 (27%)
		NHL repeat	959..997	CDD:271329	9/51 (18%)
		NHL repeat	1002..1027	CDD:271329	6/27 (22%)
Nhlrc1	NP_954706.1	zf-RING_5	22..70	CDD:291308
		NHL 1	110..154		13/48 (27%)
		NHL_TRIM32_like	115..389	CDD:271331	71/298 (24%)
		NHL repeat	126..166	CDD:271331	13/39 (33%)
		NHL 2	158..201		13/44 (30%)
		NHL repeat	174..213	CDD:271331	9/40 (23%)
		NHL 3	202..242		10/46 (22%)
		NHL repeat	215..256	CDD:271331	10/47 (21%)
		NHL 4	245..298		14/52 (27%)
		NHL repeat	258..311	CDD:271331	14/52 (27%)
		NHL 5	299..347		10/58 (17%)
		NHL repeat	319..351	CDD:271331	6/42 (14%)
		NHL 6	348..391		10/42 (24%)
		NHL repeat	362..388	CDD:271331	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010