DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and Trim2

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_038958566.1	Gene:	Trim2 / 361970	RGDID:	1310981	Length:	809	Species:	Rattus norvegicus

Alignment Length:	763	Identity:	187/763 - (24%)
Similarity:	313/763 - (41%)	Gaps:	183/763 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 RQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLL 388
            :.|.||.|...:::|.|::|...:|:||...||:         :.|.:........::::||..|
  Rat   175 KPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHA---------EHPTVPLKDVVEQHKASLQVQL 230

  Fly   389 ADMRGKIGEIVGIAGNSDQNLTKV--KLQYQKAH--NELNETHQFFASMLDERKTELLKELETLY 449
            ..:..::.||    .::.|.::::  :|..|||.  ::::.|.......|:.||:.||.|||..|
  Rat   231 DAVNKRLPEI----DSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNY 291

  Fly   450 TAKVNSNNSWQQRSRDLIDKGLATCEAVER--SPAPPSSLLTEALLLRKSLEQQLQTGIQEMQLP 512
            ..|    :...|...|.:.:|..:.::...  :.|......||.||::|.:.::|.. :.:...|
  Rat   292 GLK----HKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNE-LADQDFP 351

  Fly   513 F------EIEFMSNYQSIQAGVRNTFGYIRAN--SSDGGPTGMSLTSNGHGKQPPIARP---TQS 566
            .      :::|:...:.::..:.|....:..|  :|:...||..|      :|..|.:|   |.:
  Rat   352 LHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGL------RQTIIGQPMSVTIT 410

  Fly   567 ASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSAGGA 631
            ..:.......:|              |.:.||.              |.....|:.|
  Rat   411 TKDKDGELCKTG--------------NAYLTAE--------------LSTPDGSVAD-------- 439

  Fly   632 VGAFSNGGLLLGGRDRNALAVEQHFGELMPKRGGGG---YT-GSNGSATSAVAHYNPYEKWSNGG 692
                                     ||::..:.|..   || ...|..|.::..|:.:.:    |
  Rat   440 -------------------------GEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIR----G 475

  Fly   693 SDNLFSSVTSGVSGSSAVADAFASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKLLSATIYPPKS 757
            |......:.|        ||...:...|...|.| .|:|                     :..:.
  Rat   476 SPFKLKVIRS--------ADVSPTTEGVKRRVKS-PGSG---------------------HVKQK 510

  Fly   758 QIKRQKMIYHC--------------KFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFD 808
            .:||...:|..              :.|..|..:|:||...|||.:....|::||:||..:|||.
  Rat   511 AVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFS 575

  Fly   809 KEGRFKFQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGATILQH 873
            .:|:||.:||..|:...||..|..|| |..|||||:.:.. ...:.|::..|:|..|.|:..|..
  Rat   576 NDGQFKSRFGIRGRSPGQLQRPTGVA-VHPSGDIIIADYD-NKWVSIFSNDGKFKTKIGSGKLMG 638

  Fly   874 PRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKFGCSKH--------LEFPNGVVVNDKQEIFI 930
            |:||:||..|.||||:.|...|.||..||.::.:||...:        |:.|:...||...||.|
  Rat   639 PKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGTLDGPHFAAVNSSNEIII 703

  Fly   931 SDNRAHCVKVFNYEGQYLRQIG----GEGITNYPIGVGINSNGEILIADNHNNFNLTIFTQDGQL 991
            :|...|.|||||.||:::.:.|    |.|..|.|.||.::|||.|::|| ..|..:.:|...|..
  Rat   704 TDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVAD-WGNSRIQVFDGSGSF 767

  Fly   992 ISALESKVKHAQCFD-------VALMDDGSVVLA-SKDYRLYIYRYVQ 1031
            :|.:.:..      |       :||..||.||:| |.::...:|||:|
  Rat   768 LSYINTSA------DPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662
		zf-B_box	328..366	CDD:279037	11/37 (30%)
		NHL_brat_like	760..1030	CDD:271329	104/303 (34%)
		NHL repeat	783..819	CDD:271329	15/35 (43%)
		NHL repeat	830..871	CDD:271329	14/40 (35%)
		NHL repeat	874..910	CDD:271329	17/35 (49%)
		NHL repeat	914..954	CDD:271329	17/43 (40%)
		NHL repeat	959..997	CDD:271329	13/37 (35%)
		NHL repeat	1002..1027	CDD:271329	9/32 (28%)
Trim2	XP_038958566.1	RAD18	68..>170	CDD:227719
		RING-HC_TRIM2	81..126	CDD:319681
		Bbox2_TRIM2_C-VII	176..217	CDD:380882	13/49 (27%)
		BBC	222..348	CDD:128778	31/134 (23%)
		IG_FLMN	386..482	CDD:214720	25/166 (15%)
		NHL_TRIM2_like	532..809	CDD:271330	102/285 (36%)
		NHL repeat	550..589	CDD:271330	16/38 (42%)
		NHL repeat	597..636	CDD:271330	14/40 (35%)
		NHL repeat	639..675	CDD:271330	17/35 (49%)
		NHL repeat	683..727	CDD:271330	17/43 (40%)
		NHL repeat	736..776	CDD:271330	13/46 (28%)
		NHL repeat	779..805	CDD:271330	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020