DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and Trim9

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster

Alignment Length:	937	Identity:	176/937 - (18%)
Similarity:	294/937 - (31%)	Gaps:	352/937 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SPTPSLDSMRGGANSIESYEHAGYLSDSPLTLSGSSPPASDSAICSDEYTGGSSVKSRSEVTVIN 68
            ||..:|.....||.:..:..|.|        |.|:.              ||:...:.:.||..|
  Fly    39 SPGSALPGAVNGAGAASAAGHNG--------LHGNG--------------GGAGGGAAAPVTNPN 81

  Fly    69 GHHPISASVSSSSSASSSSCSSSSSSSSSSSSS-----SSSTSGLSGCGSTSSSVISANNVASSN 128
            |.....:|.||::|.:||:..|.|.:|....|.     |.:.||:..|.:||..|       |..
  Fly    82 GPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCSNTSRPV-------SYA 139

  Fly   129 GPGVIGSNLQSSNNGGNSGISSLVVGAGKGSNSSSNSSSSNTSANGSPP------RCTACKSK-- 185
            |.|::            .|:.::|                      :||      .|..|:..
  Fly   140 GTGLL------------PGVGNVV----------------------APPGAAYCLTCPLCRKLVF 170

  Fly   186 ----------------------CSDAVAKCFECQ------SYLCANCVTAHEFMHCFNGHNVCLI 222
                                  |:....:|..|:      |.:|..|    |..:|
  Fly   171 FDDGGVRNLPTYRAMEAIVDRFCAREALRCQMCETDPKVASLICEQC----EIRYC--------- 222

  Fly   223 KGFEASTTGTPLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQ-PMSQLSK 286
                                .|..|..:                          ||: |:::.:.
  Fly   223 --------------------DACRELTH--------------------------PARGPLAKHTL 241

  Fly   287 IVLAAAAQANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKEC 351
            :....||                            |||:..|..|::.|.:: |.:|....|..|
  Fly   242 VKPRGAA----------------------------QQRESVCGEHEETLSQY-CLSCKAPACGLC 277

  Fly   352 IVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQY 416
            |    ....|:..:|||..:|.....|.....||.|....|.....|..:.|.||: :|:..:::
  Fly   278 I----GELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDK-VTESCMEF 337

  Fly   417 QK-AHNE-------LNETHQFF--ASMLD-ERKTELLKELETLYTAKVNSNNSWQQRSRDLIDKG 470
            :: .|.:       :::..::.  |..:| :.|..:||:.::..|.|:       |::..||.
  Fly   338 ERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKL-------QQTTGLIQ-- 393

  Fly   471 LATC-EAVERSPAPPSSLLTEALLLRKSLEQQLQTGIQEM-----QLPFEIEFMSNYQSIQAGVR 529
              .| ||::.:.:  ::.|....:|...:.....|..||:     ::...::...:..::...:.
  Fly   394 --FCIEALKETDS--AAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDDAALARAID 454

  Fly   530 NTFGYIRANSSDGGPTGMSLTSNGHGKQP-----PIARPTQ-SASNSSASSAGSGHHGHHQQSHH 588
            | ..:|:          |....:|..:.|     |...|:. ||.|:|.:.|
  Fly   455 N-LNFIQ----------MRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVA------------- 495

  Fly   589 HGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSAGGAVGAFSNGGLLLGGRDRNALAVE 653
                  .|..:|      |.:.|..|.|.           .|:.|.|..   :..|::.......
  Fly   496 ------WQPPNH------SFVEGYVLELD-----------DGSGGEFRE---VYCGKETICTVDG 534

  Fly   654 QHFGELMPKR-------GGGGYTGSNGSATSAVAHYNPYEKWSNGGSDNLFSSVTSGVSGSSAV- 710
            .||..:...|       |.|.|:...|..|:.||.:.             |..|.||.:||..:
  Fly   535 LHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFT-------------FDPVLSGGAGSGLIF 586

  Fly   711 ADAFASLSAVG-------GSVVSGAG------------AGGSTVSSESLLDLT-NKLL-----SA 750
            :...|::|..|       |||....|            |........:.:|:. ||:|     |.
  Fly   587 SKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSF 651

  Fly   751 TIYPPKSQIKRQKMIY-HCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFK 814
            .:|     |.||:..: |....|..| ||..|..|.:.|       :.|...|.:.....|
  Fly   652 AMY-----IDRQRSWFQHNSIHERRV-EGGITTGSTIGV-------LLDLERHTLSFLVNE---- 699

  Fly   815 FQFGECGKRDSQ-LLYPNRVAVVRNSG 840
            ...|....||.. :.||   ||..|.|
  Fly   700 MPQGSVAFRDLYGVFYP---AVSINRG 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	12/81 (15%)
		zf-B_box	328..366	CDD:279037	9/37 (24%)
		NHL_brat_like	760..1030	CDD:271329	22/83 (27%)
		NHL repeat	783..819	CDD:271329	5/35 (14%)
		NHL repeat	830..871	CDD:271329	5/11 (45%)
		NHL repeat	874..910	CDD:271329
		NHL repeat	914..954	CDD:271329
		NHL repeat	959..997	CDD:271329
		NHL repeat	1002..1027	CDD:271329
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989	13/45 (29%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	26/135 (19%)
		FN3	472..564	CDD:238020	25/130 (19%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	47/196 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930