DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and TRIM2

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001362417.1	Gene:	TRIM2 / 23321	HGNCID:	15974	Length:	802	Species:	Homo sapiens

Alignment Length:	941	Identity:	211/941 - (22%)
Similarity:	356/941 - (37%)	Gaps:	276/941 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 CTACKSKCSDAVAKCFECQSYLCANC----VTAHEF-MHCFNGHNVCLIKGFEASTTGTP-LSVG 237
            |:.|..:..:  .|...|....|..|    :.||.. :.|    .||      ..|:..| ..|.
Human    50 CSICLERYKN--PKVLPCLHTFCERCLQNYIPAHSLTLSC----PVC------RQTSILPEKGVA 102

  Fly   238 SPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQR 302
            :..||      .:.::|..:||:....::::             |.:.:.|.|.||
Human   103 ALQNN------FFITNLMDVLQRTPGSNAEE-------------SSILETVTAVAA--------- 139

  Fly   303 EDSIYGSLHPQQQQQQQQQQQRQLFCPRH---KQ----------------------------ELL 336
                                .:.|.||.|   :|                            :::
Human   140 --------------------GKPLSCPNHDGNRQSFAVVPRLVSNPWPQVILPPWPSKVLGLQVM 184

  Fly   337 KFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLLADMRGKIGEIVGI 401
            :|.|::|...:|:||...||:         :.|.:........::::||..|..:..::.||
Human   185 EFYCQSCETAMCRECTEGEHA---------EHPTVPLKDVVEQHKASLQVQLDAVNKRLPEI--- 237

  Fly   402 AGNSDQNLTKV--KLQYQKAH--NELNETHQFFASMLDERKTELLKELETLYTAKVNSNNSWQQR 462
             .::.|.::::  :|..|||.  ::::.|.......|:.||:.||.|||..|..|    :...|.
Human   238 -DSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLK----HKVLQS 297

  Fly   463 SRDLIDKGLATCEAVER--SPAPPSSLLTEALLLRKSLEQQLQTGIQEMQLPF------EIEFMS 519
            ..|.:.:|..:.::...  :.|......||.||::|.:.::|.. :.:...|.      :::|:.
Human   298 QLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNE-LADQDFPLHPRENDQLDFIV 361

  Fly   520 NYQSIQAGVRNTFGYIRAN--SSDGGPTGMSLTSNGHGKQPPIARP---TQSASNSSASSAGSGH 579
            ..:.::..:.|....:..|  :|:...||..|      :|..|.:|   |.:..:.......:|
Human   362 ETEGLKKSIHNLGTILTTNAVASETVATGEGL------RQTIIGQPMSVTITTKDKDGELCKTG- 419

  Fly   580 HGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSAGGAVGAFSNGGLLLGG 644
                         |.:.||.              |.....|:.|
Human   420 -------------NAYLTAE--------------LSTPDGSVAD--------------------- 436

  Fly   645 RDRNALAVEQHFGELMPKRGGGG---YT-GSNGSATSAVAHYNPYEKWSNGGSDNLFSSVTSGVS 705
                        ||::..:.|..   || ...|..|.::..|:.:.:    ||......:.|
Human   437 ------------GEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIR----GSPFKLKVIRS--- 482

  Fly   706 GSSAVADAFASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKLLSATIYPPKSQIKRQKMIYHC-- 768
                 ||...:...|...|.| .|:|                     :..:..:||...:|..
Human   483 -----ADVSPTTEGVKRRVKS-PGSG---------------------HVKQKAVKRPASMYSTGK 520

  Fly   769 ------------KFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFKFQFGECG 821
                        :.|..|..:|:||...|||.:....|::||:||..:|||..:|:||.:||..|
Human   521 RKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRG 585

  Fly   822 KRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGATILQHPRGVTVDNKGRII 886
            :...||..|..|| |..|||||:.:.. ...:.|::..|:|..|.|:..|..|:||:||..|.||
Human   586 RSPGQLQRPTGVA-VHPSGDIIIADYD-NKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHII 648

  Fly   887 VVECKVMRVIIFDQNGNVLHKFGC----SKHLEFPNGVVVNDKQEIFISDNRAHCVKVFNYEGQY 947
            ||:.|...|.||..||.::.:||.    .:....|:...||...||.|:|...|.|||||.||::
Human   649 VVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEF 713

  Fly   948 LRQIG----GEGITNYPIGVGINSNGEILIADNHNNFNLTIFTQDGQLISALESKVKHAQCFD-- 1006
            :.:.|    |.|..|.|.||.::|||.|::|| ..|..:.:|...|..:|.:.:..      |
Human   714 MLKFGSNGEGNGQFNAPTGVAVDSNGNIIVAD-WGNSRIQVFDGSGSFLSYINTSA------DPL 771

  Fly  1007 -----VALMDDGSVVLA-SKDYRLYIYRYVQ 1031
                 :||..||.||:| |.::...:|||:|
Human   772 YGPQGLALTSDGHVVVADSGNHCFKVYRYLQ 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	11/47 (23%)
		zf-B_box	328..366	CDD:279037	12/68 (18%)
		NHL_brat_like	760..1030	CDD:271329	103/299 (34%)
		NHL repeat	783..819	CDD:271329	15/35 (43%)
		NHL repeat	830..871	CDD:271329	14/40 (35%)
		NHL repeat	874..910	CDD:271329	17/35 (49%)
		NHL repeat	914..954	CDD:271329	16/43 (37%)
		NHL repeat	959..997	CDD:271329	13/37 (35%)
		NHL repeat	1002..1027	CDD:271329	9/32 (28%)
TRIM2	NP_001362417.1	RAD18	33..>136	CDD:227719	21/116 (18%)
		RING-HC_TRIM2	47..92	CDD:319681	11/53 (21%)
		Bbox_SF	142..214	CDD:381767	14/80 (18%)
		BBC	219..345	CDD:128778	31/134 (23%)
		IG_FLMN	383..479	CDD:214720	25/166 (15%)
		NHL_TRIM2_like	529..802	CDD:271330	101/281 (36%)
		NHL repeat	547..586	CDD:271330	16/38 (42%)
		NHL repeat	594..633	CDD:271330	14/40 (35%)
		NHL repeat	636..672	CDD:271330	17/35 (49%)
		NHL repeat	680..720	CDD:271330	16/39 (41%)
		NHL repeat	729..769	CDD:271330	13/46 (28%)
		NHL repeat	772..798	CDD:271330	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.050