DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and Trim45

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001159425.1	Gene:	Trim45 / 229644	MGIID:	1918187	Length:	757	Species:	Mus musculus

Alignment Length:	488	Identity:	92/488 - (18%)
Similarity:	168/488 - (34%)	Gaps:	137/488 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 SNTSANGSPPRCTACKSKCSDAVAKCFECQSYLCANCVTAHEFMHCFNGHNVCLIKGFEASTTGT 232
            :|.|.:.....|..|.....  |.:...|...:|..|:   |.:..|   :|..|:|.::.|:
Mouse    18 ANASGSSGKTHCPTCLRLFK--VPRLLPCLHTVCTTCL---EKLDPF---SVVDIRGGDSDTS-- 72

  Fly   233 PLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQ--------QQQQLLPAQPMSQLSKIVL 289
              |.||...:|                   :|.|.|.|        ..|..||...:..|:...|
Mouse    73 --SEGSVFQDP-------------------ELCSLQPQIGILCPVCDAQVDLPLGGVKALTVDHL 116

  Fly   290 A------------------------------AAAQAN------SQEQQREDSIYGSLHPQQQQQQ 318
            |                              ...:||      ...::::.:.|.::...:..:.
Mouse   117 AMNDVLLENLRGEGQGLVCDLCSDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKG 181

  Fly   319 QQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESA 383
            ..|..:.:.||.|..|.|:..|..|...||::|:|.||.         :.|...||.....:..:
Mouse   182 YSQVGKPILCPSHPAEELRLFCELCDRPVCRDCVVGEHR---------EHPYDFTSNVIHKHGDS 237

  Fly   384 LQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQFFAS-----------MLDER 437
            ::.||.|.:..:           :.|.....|.:..:|.|.|..:..|:           .::|.
Mouse   238 VRELLRDTQPHV-----------EALEDALAQIKSVNNALQERVEAVAADVRTFSEGYIKAIEEH 291

  Fly   438 KTELLKELETLYTAKVNSNNSWQQRSRDL------IDKGLATCEAVERSPAPPSSLLTEALL--- 493
            :.:||::|:.:   ::....:.|.:...|      :..|:...|.:..|.:....|:|:.::
Mouse   292 RDKLLQQLDDI---RIQRETALQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVER 353

  Fly   494 LRK--SLEQQLQTGIQEMQLPFEIEFMSNYQSIQAGVRNTFGYIRANSSDGGPTGMSLTSNGHGK 556
            |||  .:|...:.|:..     :|.|....::.|......:|.|  |:.:..|....|    .|:
Mouse   354 LRKLNKVEYSARPGVNH-----KICFSPQEKAGQCQGYEVYGAI--NTQEVDPAQCVL----QGE 407

  Fly   557 QPPIARPTQSAS------NSSASSAGSGHHGHH 583
            ....||..|:||      ::|..|.|.|....|
Mouse   408 DLHRAREKQTASFTLFCKDASGQSMGRGGDNVH 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	9/45 (20%)
		zf-B_box	328..366	CDD:279037	13/37 (35%)
		NHL_brat_like	760..1030	CDD:271329
		NHL repeat	783..819	CDD:271329
		NHL repeat	830..871	CDD:271329
		NHL repeat	874..910	CDD:271329
		NHL repeat	914..954	CDD:271329
		NHL repeat	959..997	CDD:271329
		NHL repeat	1002..1027	CDD:271329
Trim45	NP_001159425.1	BBOX	189..226	CDD:237988	14/45 (31%)
		iSH2_PI3K_IA_R	237..357	CDD:304922	22/133 (17%)
		Filamin	394..497		13/51 (25%)
		Filamin	397..493	CDD:279024	13/48 (27%)
		IG_FLMN	399..497	CDD:214720	13/46 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920