DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and TRIM32

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001093149.1	Gene:	TRIM32 / 22954	HGNCID:	16380	Length:	653	Species:	Homo sapiens

Alignment Length:	898	Identity:	161/898 - (17%)
Similarity:	277/898 - (30%)	Gaps:	320/898 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 DAVAKCFECQSYLCANCVTAHE----FMHCFNGHNV---CLIKGFEASTTGTPLSVGSPSNNPAS 245
            ||:.:..||.  :|....|..:    .:||  ||.:   ||.|...:|..|    |..|
Human    12 DALREVLECP--ICMESFTEEQLRPKLLHC--GHTICRQCLEKLLASSING----VRCP------ 62

  Fly   246 NEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQREDSIYGSL 310
                :.|.:|.:....|..|:              ::.|..|..|..::|..
Human    63 ----FCSKITRITSLTQLTDN--------------LTVLKIIDTAGLSEAVG------------- 96

  Fly   311 HPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTST 375
                          .|.|....:.|.:..||:|.:::|:.|...:|          |.||..|..
Human    97 --------------LLMCRSCGRRLPRQFCRSCGLVLCEPCREADH----------QPPGHCTLP 137

  Fly   376 GSTANE----------SALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQY----QKAHNELNET 426
            ...|.|          :.|:.|:.:::.:...:.|::.:.......|..:|    ::..:||..:
Human   138 VKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQARYKAVLQEYGHEERRVQDELARS 202

  Fly   427 HQFFASMLDERKTELLKELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVERSPAPPSSLLTEA 491
            .:||...|                |:|..:||                :.||
Human   203 RKFFTGSL----------------AEVEKSNS----------------QVVE------------- 222

  Fly   492 LLLRKSLEQQLQTGIQEMQLPFEIEFMSNYQSIQAGVRNTFGYIRANSSDGGPTGMSLTSNGHGK 556
                                  |..::.|...:||..|..:...:...:|     ::|.
Human   223 ----------------------EQSYLLNIAEVQAVSRCDYFLAKIKQAD-----VALL------ 254

  Fly   557 QPPIARPTQSASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASL 621
                                                  .:||..::.:..:|| ...|.|....|
Human   255 --------------------------------------EETADEEEPELTASL-PRELTLQDVEL 280

  Fly   622 LDSSSSAGGAVGAFSNGGLLLGGRDRNALAVEQHFGELMPKRGGGGYTGSNGSATSAVAHYNPYE 686
            |        .||                     |.|.|           ..|.|.......|..:
Human   281 L--------KVG---------------------HVGPL-----------QIGQAVKKPRTVNVED 305

  Fly   687 KWSNGGSDNLFS-SVT---SGVSGSSAVADAFASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKL 747
            .|:...:.:..| |||   ..:|....||...||.:...|
Human   306 SWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRG------------------------- 345

  Fly   748 LSATIYPPKSQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGR 812
                   |::....|:.::..|.|..|...|.|..|..:.|.:|.:::|||..|:|||:|.::|.
Human   346 -------PEAASNIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGF 403

  Fly   813 FKFQFGECGKRDSQLL------YPN--RVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGAT 869
            .|.........||.:|      .||  .::|..|...:|....|..:.:::|...|..|....:.
Human   404 LKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQ 468

  Fly   870 ILQHPRGVTVDNKGRIIVVECKVMRVIIF--DQNGNVLHKFGCSKHLEFPNGVVVNDKQEIFIS- 931
             |..|.|:|....|:.:|.:.:..::..|  |:...|: |:.|......|..|..:.:..::.:
Human   469 -LSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGSGVV-KYSCLCSAVRPKFVTCDAEGTVYFTQ 531

  Fly   932 ---------DNRAHCVKVFNY-----EGQYLRQIGGEGITNYPI----GVGINSNGEILIADNHN 978
                     .|..|....|:.     :||..|||......|...    |:.:::.|::::||:..
Human   532 GLGLNLENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSR 596

  Fly   979 NFNLTIFTQDGQLISALESKVKHAQC-FDVALMDDGS-VVLASKDYRLYIYRY 1029
            ...|......|..:...|.    ..| ..:||...|. :||...|:.:.||.|
Human   597 KEILHFPKGGGYSVLIREG----LTCPVGIALTPKGQLLVLDCWDHCIKIYSY 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	11/40 (28%)
		zf-B_box	328..366	CDD:279037	8/37 (22%)
		NHL_brat_like	760..1030	CDD:271329	70/301 (23%)
		NHL repeat	783..819	CDD:271329	13/35 (37%)
		NHL repeat	830..871	CDD:271329	9/42 (21%)
		NHL repeat	874..910	CDD:271329	9/37 (24%)
		NHL repeat	914..954	CDD:271329	10/54 (19%)
		NHL repeat	959..997	CDD:271329	6/41 (15%)
		NHL repeat	1002..1027	CDD:271329	7/26 (27%)
TRIM32	NP_001093149.1	RING-HC_TRIM32_C-VII	19..65	CDD:319501	15/63 (24%)
		Bbox1_TRIM32_C-VII	98..138	CDD:380864	13/49 (27%)
		FAM184	<143..224	CDD:406160	17/147 (12%)
		NHL 1	358..401		16/42 (38%)
		NHL_TRIM32_like	362..644	CDD:271331	66/287 (23%)
		NHL 2	415..458		10/42 (24%)
		NHL 3	459..499		9/40 (23%)
		NHL 4	562..605		9/42 (21%)
		NHL 5	606..646		12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920