DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brat and RNF152

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_775828.1	Gene:	RNF152 / 220441	HGNCID:	26811	Length:	203	Species:	Homo sapiens

Alignment Length:	153	Identity:	31/153 - (20%)
Similarity:	52/153 - (33%)	Gaps:	49/153 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 KCFECQSYLCANCV----TAHEFMHCFNGHNVC-LIKGFEAS-----------------TTGTPL 234
            |..:|:...|:.|:    |:.:.:.|.....|. |..||..|                 :..||:
Human    26 KLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPV 90

  Fly   235 SVGSPSNNPASNEFKYASSLTMMLQQQQQL-----------DSQQQQQQQQLLPA--QPMSQLSK 286
            .:..|||.        ...|.:.:.:::.|           .|||:......:||  ||:..
Human    91 FIKLPSNG--------CYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQG--- 144

  Fly   287 IVLAAAAQANSQEQQREDSIYGS 309
               .|..:|..:||.|...:..|
Human   145 ---GAPQEAVEEEQDRRGVVKSS 164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	7/34 (21%)
		zf-B_box	328..366	CDD:279037
		NHL_brat_like	760..1030	CDD:271329
		NHL repeat	783..819	CDD:271329
		NHL repeat	830..871	CDD:271329
		NHL repeat	874..910	CDD:271329
		NHL repeat	914..954	CDD:271329
		NHL repeat	959..997	CDD:271329
		NHL repeat	1002..1027	CDD:271329
RNF152	NP_775828.1	RING-HC_RNF152	11..55	CDD:319462	6/28 (21%)
RNF152	NP_775828.1	Necessary for interaction with RRAGA. /evidence=ECO:0000269\|PubMed:25936802	106..165		14/65 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010