DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brat and Trim25

DIOPT Version :9

Sequence 1:NP_001188842.2 Gene:brat / 35197 FlyBaseID:FBgn0010300 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_033572.2 Gene:Trim25 / 217069 MGIID:102749 Length:634 Species:Mus musculus


Alignment Length:585 Identity:111/585 - (18%)
Similarity:190/585 - (32%) Gaps:196/585 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 GSNSSSNSSSSNTSANGSPPRCTACKSKCSDAVAKCFECQSYLCAN---CVTAHEFMHCFNGHNV 219
            |.|...:.........|.|.||..|:        |.::.:..|..|   |....:|:        
Mouse    29 GHNFCMSCLDETWVVQGPPYRCPQCR--------KVYQVRPQLQKNTVMCAVVEQFL-------- 77

  Fly   220 CLIKGFEASTTGTPLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQL 284
                  :|....||:...:|   ||  .|..:|:.|                  |:.....::::
Mouse    78 ------QAEQARTPVDDWTP---PA--RFSASSAAT------------------QVACDHCLTEI 113

  Fly   285 SKIVLAAAAQANSQEQQRE--DSIYGSLHPQQ--------QQQQQQQQQRQLFCPRHKQELLKFS 339
            :.........:..||..|.  ||.....||.|        ::..|..:.|:||||.|.:      
Mouse   114 AVKTCLVCMASFCQEHLRPHFDSPAFQDHPLQSPIRDLLRRKCTQHNRLRELFCPEHGE------ 172

  Fly   340 CRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLLADMRGKIG------EI 398
                ||  |..|:| ||.|        .|| .|.|..|...|..|:..|..|...|.      |.
Mouse   173 ----CI--CHICLV-EHKT--------CSP-TTLSQASADLEYKLRNKLTIMHSHINGATKALED 221

  Fly   399 VGIAGNSDQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELLKEL-----------ETLYTAK 452
            |.......|:..|.|::      :|.:.:....:::|..:|..|::|           :|:|...
Mouse   222 VRSKQQCVQDSMKRKME------QLRQEYMEMKAVIDAAETSSLRKLKEEEKRVYGKFDTIYQVL 280

  Fly   453 VNSNNSWQQRSRD---LIDKGLATCEAVER-------SPAP---PSSLLTEALLL-----RKSLE 499
            |...:..|:...:   ::||| ...|.:|:       |..|   |...|...|::     ...|:
Mouse   281 VKKKSEMQKLKAEVELIMDKG-DEFEFLEKAAKLQGESTKPVYIPKIDLDHDLIMGIYQGAADLK 344

  Fly   500 QQLQTGIQEMQLPFE---------IEFMSNYQSIQAGVRN------------------------- 530
            .:|:..|:::|...|         .:..|.::.:|...:.                         
Mouse   345 SELKHSIKKLQKKSEEHNGSGNKGDQTQSTFKPVQPSKKTIQEKKTKKTPVAPGPPSHFSPNKLP 409

  Fly   531 TFGY------IRANSSDGGPTGMSLTSNGHGKQPPI-------------------------ARPT 564
            |||.      .:|.|.|..|...:...:..|.:..:                         |...
Mouse   410 TFGAPGQSLDSKATSPDAAPKASAAQPDSVGVKAKVLENFLTKSRTELLEYFVKVIFDYNTAHNK 474

  Fly   565 QSASN---SSASSAGSGHHGHHQQ-----SHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASL 621
            .|.||   :::.|.|..|:..|.|     |...|.|.:....|:.:::.|.: :..|:|:...|:
Mouse   475 VSLSNKYTTASVSDGLQHYRSHPQRFTYCSQVLGLHCYKNGIHYWEVELQKN-NFCGVGICYGSM 538

  Fly   622  621
            Mouse   539  538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bratNP_001188842.2 BBOX 176..222 CDD:197662 9/48 (19%)
zf-B_box 328..366 CDD:279037 11/37 (30%)
NHL_brat_like 760..1030 CDD:271329
NHL repeat 783..819 CDD:271329
NHL repeat 830..871 CDD:271329
NHL repeat 874..910 CDD:271329
NHL repeat 914..954 CDD:271329
NHL repeat 959..997 CDD:271329
NHL repeat 1002..1027 CDD:271329
Trim25NP_033572.2 RING 13..53 CDD:302633 6/23 (26%)
PspA 229..>360 CDD:224755 26/137 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..437 11/83 (13%)
SPRY_PRY_TRIM25 464..632 CDD:293971 17/76 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2677
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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