DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brat and Nhlrc3

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_766089.1	Gene:	Nhlrc3 / 212114	MGIID:	2444520	Length:	347	Species:	Mus musculus

Alignment Length:	264	Identity:	51/264 - (19%)
Similarity:	102/264 - (38%)	Gaps:	80/264 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   867 GATILQHPRGVTVDNKGRIIVVECK---VMRVIIFDQNGNVLHKFGCSKHLEFPNGVVVND---K 925
            |||..     |.||:...::.|..:   :.:|::|.::|..|..:..:  ::.|:|:.|:.   :
Mouse    61 GATFC-----VAVDSLNGLVYVAQRGDNIPKVLVFSEDGYFLRAWNYT--VDTPHGMFVSGTPFE 118

  Fly   926 QEIFISD----NRAHCVKVFNYEGQYLRQIG-----GEGIT----NYPIGVGINSNGEILIADNH 977
            |.::|:|    ...|.||.:|..|..::.:|     |.|:.    :.|..:.::..||:.|.|..
Mouse   119 QSVWITDVGSGPYGHTVKKYNSLGDLVQVLGTPGKKGTGLNPLQFDNPAELYVDDTGEMYIVDGD 183

  Fly   978 NNFN--LTIFTQDGQLI--------SALESKVKHAQCFDVALMDDGSVVLASK-DYRLYIY---- 1027
            ...|  |...:||..::        ...:..:.|:...|..    |.|.:|.: :.||.::
Mouse   184 GGLNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDAV----GRVWVADRGNKRLQVFDKDT 244

  Fly  1028 -------------------------RYVQLAPVVLHKLHSNINETSKSF----------LADRIQ 1057
                                     :|:.:|.:.|.:|...:...|.|.          |||::.
Mouse   245 GEWLGAWDNCFTEEGPSAVRFTPDGKYLIVAQLNLSRLSVLLAPPSGSIGDCSVVSTIQLADQVL 309

  Fly  1058 QHFI 1061
            .|.:
Mouse   310 PHLL 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662
		zf-B_box	328..366	CDD:279037
		NHL_brat_like	760..1030	CDD:271329	41/221 (19%)
		NHL repeat	783..819	CDD:271329
		NHL repeat	830..871	CDD:271329	3/3 (100%)
		NHL repeat	874..910	CDD:271329	8/38 (21%)
		NHL repeat	914..954	CDD:271329	12/51 (24%)
		NHL repeat	959..997	CDD:271329	9/47 (19%)
		NHL repeat	1002..1027	CDD:271329	6/25 (24%)
Nhlrc3	NP_766089.1	NHL 1	47..93		9/36 (25%)
		NHL	66..336	CDD:302697	48/254 (19%)
		YncE	<66..308	CDD:225926	47/247 (19%)
		NHL repeat	107..153	CDD:271320	12/45 (27%)
		NHL 2	150..196		9/45 (20%)
		NHL repeat	166..205	CDD:271320	9/38 (24%)
		NHL 3	200..243		7/46 (15%)
		NHL repeat	213..250	CDD:271320	7/40 (18%)
		NHL repeat	258..299	CDD:271320	6/40 (15%)
		NHL 4	294..338		4/20 (20%)
		NHL repeat	308..335	CDD:271320	1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010