DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brat and nhl-2

DIOPT Version :9

Sequence 1:NP_001188842.2 Gene:brat / 35197 FlyBaseID:FBgn0010300 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_498026.1 Gene:nhl-2 / 175654 WormBaseID:WBGene00003598 Length:1032 Species:Caenorhabditis elegans


Alignment Length:1180 Identity:247/1180 - (20%)
Similarity:425/1180 - (36%) Gaps:341/1180 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SSPTPSLDSMRGGANSIESYEHAGYLSDSPLTLSGSSP-PASDSAICSDEYTGGSSVKSRSEVTV 66
            :|.||||:    |.:.:.|      .|.||  |.|:.| |..|.|.|  .|......|.|    |
 Worm    28 NSGTPSLN----GQDPLRS------TSSSP--LFGTEPLPEDDHASC--PYCQQDFRKPR----V 74

  Fly    67 INGHHPISASVSSSSSASSSSCSSS---------SSSSSSSSSSSSSTSGLSGCGSTSSSVISAN 122
            ::..|              |.|...         .:.|::......:|:.:..|...:..|    
 Worm    75 LDCLH--------------SMCEDCIIAQLDGHLQAKSAAIEEKKRATAAMLDCELETPKV---- 121

  Fly   123 NVASSNGPGVIGSNL--QSSNNGGN-SGISSLVVGAGKGSNSSSNSSSSNTSANGSPPRCTACKS 184
             ......||||...:  |.|:.|.: ..:.::::...:.:...........:.:..|  ||||||
 Worm   122 -KERPTPPGVIRCPICSQESHVGNDVRYVHAMLLDFVRLAEMKEVEVEKMVAHHRKP--CTACKS 183

  Fly   185 KCSDAVAKCFECQSYLCANCVTAHEFMHCFNGHNVCLIKGFEASTTGTPLSVGSPSNNPASNEFK 249
            : .:|:|.|.:|.|.||.||.|||..|:.|.||.|         ||...|               
 Worm   184 E-QEAIAFCDQCSSDLCENCTTAHTVMNLFQGHTV---------TTFADL--------------- 223

  Fly   250 YASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAAQANSQEQQREDSIYGSLHPQQ 314
                                        .||                            ..||  
 Worm   224 ----------------------------RQP----------------------------GAHP-- 230

  Fly   315 QQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTA 379
                   :.||:.|..|.|. :::.|..|....||:|:.::|..  |::.::             
 Worm   231 -------ELRQVMCSTHNQH-MRYLCAACETAACKQCLEVDHLN--HKIIDI------------- 272

  Fly   380 NESALQTLLADMRGKIGEIVGIAGNS--DQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELL 442
            ||..:..:..|:...:..:.....||  |.|....|.|      :|||.::.....:|:...||.
 Worm   273 NELVINAIREDVTSTVDRVEKKYNNSVADMNSLPDKSQ------QLNEQYEIAKYRVDKHYEELR 331

  Fly   443 KELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVERSPAPPS----------SLLT-----EAL 492
            ..:|..|...||.....:.|....||      |...:|....:          .|||     |.:
 Worm   332 NSIEEAYQKSVNDLEEARIRQESNID------EMYRKSQVNEARVHDAINFTRRLLTKGNGLELV 390

  Fly   493 LLRKSLEQQ---LQTGIQEMQLPFEIEFMSNYQS-----------------IQAGVRNTFGYIRA 537
            :.||.:.||   |...|.......|:||.:..:.                 ||..|::. |...|
 Worm   391 VSRKKVIQQFGNLSHAIPSHGHQVELEFYTPSKKQIDHFVHQLTGTVIGRVIQPTVKDV-GNATA 454

  Fly   538 NSSDGGPTGMSLTSNGHGKQPPIARPTQS--------ASNSSASSAG--------SGHHGHHQQS 586
            .|:|....|.|  ..|.|:....|.|:|.        :.|....:.|        :|.:|....|
 Worm   455 ASTDRSERGGS--QPGGGRSSSAANPSQQDEWGRPVYSQNPQLGAIGGERKKNTQNGTNGTRGDS 517

  Fly   587 HHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGA------------SLLDSSSSAGGAVGAFSNGG 639
            :..|  ....::|..:......:.|....::||            .|.:..::|..|..|     
 Worm   518 NAFG--GWPPSSHPPESTTPPPVTGPQTMITGAPTQTAAPIVSQQQLSNLPNAAAMAAAA----- 575

  Fly   640 LLLGGRDRNALAVEQHFGELMPKRGGGGYTGSNGSATSAVAHYNPYEKWSNGGSDNLFSSVTSGV 704
               .|...:.:|:..:..:|.....|    .:|||.|.......|....:..|...:.:..|:|:
 Worm   576 ---AGMRPDLVALAANHMDLAALTNG----STNGSQTPLPESIFPAMWNARQGLPAVATPTTTGL 633

  Fly   705 SGSSAVA-----------------------------------DAFASLSAVGG-----SVVSGAG 729
            |.:::.|                                   ..|.:::|:|.     .:.|.|.
 Worm   634 STNASAAYMQQKLAAAQLQALASHRLNPQIMSMNNLRTNQTIQEFLAMNAMGNLSLNPQLTSAAA 698

  Fly   730 AG-GSTVSSESLLDLTNKLLSATIYPPKSQIKRQK---MIYHCKFG--EFGVMEGQFTEPSGVAV 788
            |. .:|.::.|.:..|    ::.:...::....|:   :..|..||  :.|....:...|||..:
 Worm   699 AALAATAAANSAVTTT----ASDVGQSQNSANAQRVSDLKVHSVFGTSQQGSTIRELHCPSGFCL 759

  Fly   789 NAQNDIIVADTNNHRIQIFDKEGRFKFQFGECGKRDSQLLYPNRVAVVRNSG-DIIVTER--SPT 850
            :..:||::|||||||:.:......:|  .|..|..|.||.:|.:|..:|... ..:|.::  ...
 Worm   760 SDTDDILIADTNNHRVVVCGPPHPWK--IGRPGTDDGQLCFPRKVIALRGEAVRYVVLDKGGDGK 822

  Fly   851 HQIQIYNQYGQFVRKFGATILQHPRG---------------VTVDNKGRIIVVECKVMRVIIFDQ 900
            .:.||:...|:||::.....|. |||               :.||..|.:..::....||..:  
 Worm   823 TRAQIFEARGEFVKRLNMMALV-PRGGIEVSAAAATPNGQLLLVDTAGFVYSIDVDAPRVTFW-- 884

  Fly   901 NGNVLHKFGCSKHLEFPNGVVVNDKQEIFISDNRAHCVKVFNYEGQYLRQIGGEGITNYPIGVGI 965
                   |..|..|...:.|.:.|.. |:|:|.:.|||:|:..||:::|::|....|.||||:.:
 Worm   885 -------FDASTQLGEASDVAMFDNL-IYITDFKHHCVQVYTSEGKFIRKMGEPSQTPYPIGIDV 941

  Fly   966 NSNGEILIADNH-NNFNLTIFTQDGQLI-SALESKVKHAQCFDVALMDDGSVV-LASKDYRLYIY 1027
            :..||:|:||.| |:.::.:|:.:||.| |...::.:.::|..:.:...|.:| |...::.|:::
 Worm   942 SKAGEVLVADTHGNHLHVVVFSPEGQHIHSFTHNEFRLSRCVGLRIAKSGHIVTLCKHNHTLFVF 1006

  Fly  1028 RYVQLAPVVL 1037
            :     |::|
 Worm  1007 K-----PLIL 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bratNP_001188842.2 BBOX 176..222 CDD:197662 24/45 (53%)
zf-B_box 328..366 CDD:279037 10/37 (27%)
NHL_brat_like 760..1030 CDD:271329 79/295 (27%)
NHL repeat 783..819 CDD:271329 13/35 (37%)
NHL repeat 830..871 CDD:271329 9/43 (21%)
NHL repeat 874..910 CDD:271329 9/50 (18%)
NHL repeat 914..954 CDD:271329 14/39 (36%)
NHL repeat 959..997 CDD:271329 16/39 (41%)
NHL repeat 1002..1027 CDD:271329 5/25 (20%)
nhl-2NP_498026.1 RING 62..>86 CDD:214546 8/43 (19%)
BBOX 173..217 CDD:197662 23/46 (50%)
BBOX 233..272 CDD:197662 12/41 (29%)
BBC 280..406 CDD:128778 31/137 (23%)
NHL_brat_like 729..1009 CDD:271329 78/297 (26%)
NHL repeat 754..788 CDD:271329 13/35 (37%)
NHL repeat 799..843 CDD:271329 9/43 (21%)
NHL repeat 846..887 CDD:271329 8/49 (16%)
NHL repeat 891..930 CDD:271329 14/39 (36%)
NHL repeat 935..974 CDD:271329 16/38 (42%)
NHL repeat 980..1006 CDD:271329 5/25 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D133242at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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