DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and lin-41

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001020998.1	Gene:	lin-41 / 172760	WormBaseID:	WBGene00003026	Length:	1147	Species:	Caenorhabditis elegans

Alignment Length:	1103	Identity:	233/1103 - (21%)
Similarity:	373/1103 - (33%)	Gaps:	335/1103 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASSPTPSLDSMRGGANSIE-----SYEHAGYLSDSPLTLSGSSPPASDSAICSDEYTGGSSVKS 60
            |:...||::::....:..:.     |:..:| :..||..:.|:..|:|         .||..::
Worm   183 MSDCSTPTMNNHINSSTPLHQPRAFSFSLSG-MPGSPSPVMGARMPSS---------AGGLMMR- 236

  Fly    61 RSEVTVINGHHPISASVSSSSSASSSSCSSSSSSSSSSSSSSSSTSGLSGCGSTSSSVISANNVA 125
                       ||....|.||..|.|.....|..|.::.||..        |....|.:...||.
Worm   237 -----------PIGFPDSDSSLTSWSPLQQPSQLSINNLSSIG--------GHQQQSPMLMQNVF 282

  Fly   126 SS---NGPGVIGSNLQSSNNGGNSGIS----------SLVVGAGKGSNSSS---------NSSSS 168
            .|   |....:.|.|..:|...:...|          |..:...:.|..|:         :|.|.
Worm   283 DSLAVNDDTPVFSPLSPTNTSMHMPPSLMASPDVPKHSATIAPPRNSMCSTPRLQLATPMSSQSQ 347

  Fly   169 NT----SANGSPP---------RCTACKSKCSDAVAKCFECQSYLCANCVTAHEFMHCFNGHNVC 220
            .|    |..||.|         :|..|:||.|  .|.|.:||..||.:||.||:.:.....|...
Worm   348 QTFPIPSPLGSQPQQQQPMGPIQCQGCESKIS--FAYCMQCQEALCIHCVQAHQRVRATKQHAFV 410

  Fly   221 LIKGFEASTTGTPLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLS 285
            .::...|                           |:|   .:.:..||.||..|.:.......|.
Worm   411 ELQQLMA---------------------------TLM---SRAVQPQQAQQYTQNVGGSVRQALG 445

  Fly   286 KIVLAAAAQANSQEQQREDSI-YGSLHPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTC--CILV 347
            .:.......:........||| .|...|:...          .|..|...::.. |..|  .:|:
Worm   446 SVGSGDVFFSGHVSGVENDSIGSGESSPRSSS----------VCGTHDSVIIGI-CENCPHSVLL 499

  Fly   348 CKECIVLEHSTGLHELENVQSPG-MTTSTGSTANESALQTLLADMRG-KIGEIV-GIAGNSDQNL 409
            |..| |.:| .|.|   .||..| :..:.|...|||.|.....:..| .|.:|: ||..|:
Worm   500 CAIC-VAQH-PGKH---RVQPLGDIRVAVGEVVNESQLLQWQCEKTGDTIKQIIDGIVTNA---- 555

  Fly   410 TKVKLQYQKAHNELNETHQFFASMLDERKTELLKELETLYTAK----VNSNNSWQQRSRDL---- 466
                   ..|.||:........:.|:||:.||||.:||:...|    ::...|.|.:..||
Worm   556 -------TTAENEIRAAFDTHVNALEERRKELLKRVETVKNLKLSVLISQAESLQSKQIDLQQAI 613

  Fly   467 -------------------IDKGLATCEAVERSPAPPSSLLTEALLLRKSLEQQLQTGIQEMQLP 512
                               :.:.||:|:.......|.:::|...:|..:..|..
Worm   614 QTATKLMDSSDCDEMVLRQVFEKLASCQMGNEGTEPNNNILNVLMLACQVNEDD----------- 667

  Fly   513 FEIEFMSNYQSIQAGVRNTFGYIRANSSDGGPTGMSLTSNGHGKQPPIARPTQS----------- 566
             .::|.:....|.......||.|     :.||...:.:..|...:..| |..|:
Worm   668 -RLKFTAPQDGILLNKARQFGNI-----ESGPCAKNSSIVGDSFKKAI-RERQTVIYVQLRDACG 725

  Fly   567 ---ASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSA 628
               :|:.:|:...|.....||:.|          :|.:|....|.:....:...|::
Worm   726 DLLSSSIAATQPTSQALLPHQEPH----------SHLEQAMPTSDVQAFVISPDGST-------- 772

  Fly   629 GGAVGAFSNGGLLLGGRDRNALAVEQHFGELMPKRGGGGYTGSNGSATSAVAHYNPYEKWSNGGS 693
                                   ||.   .:.|:..|          ..|:::|...|
Worm   773 -----------------------VEV---TMTPRENG----------IVALSYYPSIE------- 794

  Fly   694 DNLFSSVTSGVSGSSAVADAFASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKLLSATIYPPKSQ 758
                .|.|..:              .|.|:.:||.                         |....
Worm   795 ----GSYTLNI--------------LVKGTPISGC-------------------------PTTMD 816

  Fly   759 IKRQKMIYH-------CKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFKFQ 816
            |:|.:....       ..||:.|..:|:...|.|:.|:.:..:||||.:|:|:|||||:|.|..:
Worm   817 IRRGRNYDEIAAKGPILTFGKEGSGDGELCRPWGICVDQRGRVIVADRSNNRVQIFDKDGNFISK 881

  Fly   817 FGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFG-----ATILQHPRG 876
            ||..|.|..|...|  ..:..||.:.||......|::|::::.|.|:.|||     .....:|.|
Worm   882 FGTSGNRPGQFDRP--AGITTNSLNNIVVADKDNHRVQVFDENGMFLLKFGDRGRAVGYFNYPWG 944

  Fly   877 VTVDNKGRIIVVECKVMRVIIFDQNGNVLHKFGCS-----KHLEFPNGVVVNDKQEIFISDNRAH 936
            |..::...|.|.:.:..||.||...|..:.|.|..     |:|:.|.|:......::.|:|...|
Worm   945 VATNSHNAIAVSDTRNHRVQIFTPQGQFVRKCGFDSAYFFKNLDSPRGLCYLPDGQLLITDFNNH 1009

  Fly   937 C-----------VKVFNYEGQYLRQIGGEGITNYPIGVGINSNGEILIADNHNNFNLTIFTQD 988
            .           :||:..||.      |:|:...|.||.|:..|.||:.|:.|| .:.:|..|
Worm  1010 RLAVLSPRNMSEMKVYGSEGD------GDGMFVRPQGVVIDPEGHILVCDSRNN-RVQVFASD 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	17/54 (31%)
		zf-B_box	328..366	CDD:279037	11/39 (28%)
		NHL_brat_like	760..1030	CDD:271329	75/257 (29%)
		NHL repeat	783..819	CDD:271329	17/35 (49%)
		NHL repeat	830..871	CDD:271329	12/45 (27%)
		NHL repeat	874..910	CDD:271329	11/35 (31%)
		NHL repeat	914..954	CDD:271329	10/50 (20%)
		NHL repeat	959..997	CDD:271329	12/30 (40%)
		NHL repeat	1002..1027	CDD:271329
lin-41	NP_001020998.1	BBOX	478..516	CDD:197662	13/43 (30%)
		BBC	519..645	CDD:128778	31/136 (23%)
		Filamin	693..812	CDD:279024	28/223 (13%)
		NHL_TRIM71_like	823..1147	CDD:271324	74/252 (29%)
		YncE	847..1144	CDD:225926	70/228 (31%)
		NHL repeat	848..887	CDD:271324	18/38 (47%)
		NHL repeat	895..934	CDD:271324	12/40 (30%)
		NHL repeat	942..978	CDD:271324	11/35 (31%)
		NHL repeat	987..1028	CDD:271324	8/40 (20%)
		NHL repeat	1037..1067	CDD:271324	12/30 (40%)
		NHL repeat	1121..1147	CDD:271324
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6741
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870