DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and TRIM71

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001034200.1	Gene:	TRIM71 / 131405	HGNCID:	32669	Length:	868	Species:	Homo sapiens

Alignment Length:	1083	Identity:	245/1083 - (22%)
Similarity:	396/1083 - (36%)	Gaps:	362/1083 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SSPPASDSAIC--SDEYTGGSSVKSRSEVTVINGHHPISASVSSSSSASSSSCSSSSSSSSSSSS 100
            :|.|.:|..||  ..|..|..:              |:|              |:||:|||||.:
Human     2 ASFPETDFQICLLCKEMCGSPA--------------PLS--------------SNSSASSSSSQT 38

  Fly   101 SSSSTSGLSGCGSTSSSV-------------ISANNVASSNGPGVIG------------------ 134
            |:||..|..|.|:.:..:             :.|:.:.::.| |..|
Human    39 STSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAGG-GAAGEPLKLRCPVCDQKVVLAE 102

  Fly   135 --------------SNL---------QSSNNGGNSGISSLVVGAGKGSNSSSNSSSSNTSANGSP 176
                          |||         :.....|.:|..:   |||..||...::..::..|:.|.
Human   103 AAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPA---GAGGHSNHRHHAHHAHPRASASA 164

  Fly   177 P--------------------------------RCTACKSKCSDAVAKCFECQSYLCANCVTAHE 209
            |                                .|::| .:.:.|.::|.:||.:||.|||.||:
Human   165 PPLPQAPQPPAPSRSAPGGPAASPSALLLRRPHGCSSC-DEGNAASSRCLDCQEHLCDNCVRAHQ 228

  Fly   210 FMHCFNGHNVCLIK----GFEASTTGTPLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQ 270
            .:.....|   .|:    |..|:.....|.:|.|
Human   229 RVRLTKDH---YIERGPPGPGAAAAAQQLGLGPP------------------------------- 259

  Fly   271 QQQQLLPAQPMSQLSKIVLAAAAQANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQEL 335
                 .|..|.|.|                        |:.|          :|..||..|..|:
Human   260 -----FPGPPFSIL------------------------SVFP----------ERLGFCQHHDDEV 285

  Fly   336 LKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQ-------TLLAD-MR 392
            |...|.||.:.:|:||.:..|  |.|....:|              .|||       .|||| .:
Human   286 LHLYCDTCSVPICRECTMGRH--GGHSFIYLQ--------------EALQDSRALTIQLLADAQQ 334

  Fly   393 GKIGEIVGIAGNSDQNLT-KVKLQYQKAHNELNETHQFFASMLDERKTELLKELETLYTAKVNSN 456
            |:  :.:.::....|.:. :|:::.:...:|:..........|:||:.|||.::|.:...|..|.
Human   335 GR--QAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSL 397

  Fly   457 NSWQQRSRDLIDKGLATCEAVERSPAPPSSLLTEALLLRKSL---EQQLQTGIQEMQLPFE---I 515
            ....::.|..::|..:|..||::......:|  :.||.|..:   .|:|:| ::.:..|.|   :
Human   398 YLQVEKLRQNLNKLESTISAVQQVLEEGRAL--DILLARDRMLAQVQELKT-VRSLLQPQEDDRV 459

  Fly   516 EFMSNYQSIQAGVRNTFGYIRANSSDGG------PTGMSLTSNGHGKQPPIARPTQSASNSSASS 574
            .|....|::...:: :||::    |.|.      .||..|.....||.            :|.:.
Human   460 MFTPPDQALYLAIK-SFGFV----SSGAFAPLTKATGDGLKRALQGKV------------ASFTV 507

  Fly   575 AGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSAGGAVGAFSNGG 639
            .|..|.|..:                               |||..|:.:
Human   508 IGYDHDGEPR-------------------------------LSGGDLMSA--------------- 526

  Fly   640 LLLGGRDRNALAVEQHFGELMPKRGGGGYTGSNGSATSAVAHYNPYEKWSNGGSDNL-------- 696
             ::.|.|.|.      ||..:..:..|.|          |..|.|..:..:..|..|
Human   527 -VVLGPDGNL------FGAEVSDQQNGTY----------VVSYRPQLEGEHLVSVTLCNQHIENS 574

  Fly   697 -FSSVTSGVSGSSAVADAFASLS--AVGGSVVSGAGAGGSTVSSESLL---DLTNKLLSATIYPP 755
             |..|..  ||.|.|......||  :.|.|........|.:|..|..:   |.:|.
Human   575 PFKVVVK--SGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKEGYIIVADRSNN--------- 628

  Fly   756 KSQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFKFQFGEC 820
            :.|:.:....:|.|||..|...|||..|:|||.:|...|:|||.:|||||||..||:|..:|||.
Human   629 RIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEK 693

  Fly   821 GKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFG--ATILQH---PRGVTVD 880
            |.::.|..||..|| |.:.|.|:|:: :..|:||::...|.|:.|:|  ..:.:|   ||||..:
Human   694 GTKNGQFNYPWDVA-VNSEGKILVSD-TRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFN 756

  Fly   881 NKGRIIVVECKVMRVIIFD---QNGNVLHKFGCSKHLEF--PNGVVVNDKQEIFISDNRAHCVKV 940
            ::|.::|.:....|:::..   |:...|...|.... :|  |.||.|:.:..|.::|:|.|.|::
Human   757 HEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNG-QFLRPQGVAVDQEGRIIVADSRNHRVQM 820

  Fly   941 FNYEGQYLRQIG----GEGITNYPIGVGINSNGEILIADNHNN 979
            |...|.:|.:.|    |.|..:.|.|:.|..:|.|::.|..||
Human   821 FESNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNN 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662	15/77 (19%)
		zf-B_box	328..366	CDD:279037	13/37 (35%)
		NHL_brat_like	760..1030	CDD:271329	82/234 (35%)
		NHL repeat	783..819	CDD:271329	20/35 (57%)
		NHL repeat	830..871	CDD:271329	14/42 (33%)
		NHL repeat	874..910	CDD:271329	9/38 (24%)
		NHL repeat	914..954	CDD:271329	14/45 (31%)
		NHL repeat	959..997	CDD:271329	8/21 (38%)
		NHL repeat	1002..1027	CDD:271329
TRIM71	NP_001034200.1	RING-HC_TRIM71_C-VII	8..97	CDD:319503	25/117 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..49		13/36 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..189		10/64 (16%)
		Bbox1_TRIM71_C-VII	198..240	CDD:380870	15/45 (33%)
		Bbox2_TRIM71_C-VII	277..322	CDD:380854	18/60 (30%)
		BBC	314..444	CDD:128778	31/147 (21%)
		Filamin	479..580		28/175 (16%)
		Filamin	482..577	CDD:395505	25/169 (15%)
		NHL_TRIM71_like	584..868	CDD:271324	94/292 (32%)
		NHL 1	593..636		10/51 (20%)
		NHL repeat	609..648	CDD:271324	10/47 (21%)
		NHL 2	640..683		24/42 (57%)
		NHL repeat	656..695	CDD:271324	22/38 (58%)
		NHL 3	687..730		16/44 (36%)
		NHL repeat	703..739	CDD:271324	13/37 (35%)
		WD40 repeat	704..740	CDD:293791	13/37 (35%)
		NHL 4	734..777		10/42 (24%)
		NHL repeat	747..787	CDD:271324	9/39 (23%)
		NHL 5	781..824		13/43 (30%)
		NHL repeat	796..826	CDD:271324	10/29 (34%)
		NHL 6	828..868		12/36 (33%)
		NHL repeat	842..868	CDD:271324	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920