DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brat and Nhlrc1

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_780549.1	Gene:	Nhlrc1 / 105193	MGIID:	2145264	Length:	401	Species:	Mus musculus

Alignment Length:	331	Identity:	77/331 - (23%)
Similarity:	130/331 - (39%)	Gaps:	68/331 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   739 SLLDLTNKLLSATIYPPKSQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNAQND-IIVADTNNH 802
            |.|..:...|||..:.|.:     ...||. ||.:|.:    ..|:|:|:..:.. ::|......
Mouse    97 STLHASPAALSAAPFAPGT-----LTCYHA-FGGWGTL----VNPTGLALCPKTGRVVVVHDGKR 151

  Fly   803 RIQIFDKEGRFKFQFGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYG------- 860
            |::|||..|....||||.|.....:.||..|||. |...::||:.... .:::::.:|
Mouse   152 RVKIFDSGGGGAHQFGEKGDAAHDVKYPLDVAVT-NDCHVVVTDAGDC-SLKVFDFFGQIKLVVG 214

  Fly   861 -QFVRKFGATILQHPRGVTVDNKGRIIVVECKVMRVIIFDQNGNVLHKF-GCSKHLEFPNGVVVN 923
             ||...:|..|..| .||.|.:      .|...:.::..|....||.:. ....||..|.|:.|:
Mouse   215 KQFSLPWGVEITPH-NGVLVTD------AEAGTLHLLEADFPEGVLRRIERLQAHLCSPRGLAVS 272

  Fly   924 ------DKQEIFISDNRAHC----VKVFNYEGQYLRQIGGEGIT-NYP-----IGVGINSNGEIL 972
                  ...|...:..|..|    |||||...|.:.|:...|:. .:|     ..|..:..|.::
Mouse   273 WLTGAIAVLEHPCAFGRTGCNNTRVKVFNSTMQLIGQVDSFGLNLLFPSKVTASAVTFDHQGNVI 337

  Fly   973 IADNHNNFNLTIFTQDGQLI---------SALESKVKHAQCFDVAL---MDDGSVVLASKDYRLY 1025
            :||.           .|..|         .||:..:.|.....|||   .::..:||.:..:.:.
Mouse   338 VADT-----------SGPAIVCLGKPEEFPALKPIITHGLSRPVALAFTKENSLLVLDTASHSIK 391

  Fly  1026 IYRYVQ 1031
            :::.::
Mouse   392 VFKVME 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662
		zf-B_box	328..366	CDD:279037
		NHL_brat_like	760..1030	CDD:271329	71/307 (23%)
		NHL repeat	783..819	CDD:271329	11/36 (31%)
		NHL repeat	830..871	CDD:271329	11/48 (23%)
		NHL repeat	874..910	CDD:271329	7/36 (19%)
		NHL repeat	914..954	CDD:271329	14/49 (29%)
		NHL repeat	959..997	CDD:271329	9/51 (18%)
		NHL repeat	1002..1027	CDD:271329	5/27 (19%)
Nhlrc1	NP_780549.1	zf-RING_5	27..75	CDD:291308
		NHL 1	115..159		13/53 (25%)
		NHL_TRIM32_like	120..394	CDD:271331	70/298 (23%)
		NHL repeat	131..171	CDD:271331	13/39 (33%)
		NHL 2	163..206		13/44 (30%)
		NHL repeat	179..218	CDD:271331	9/40 (23%)
		NHL 3	207..247		10/46 (22%)
		NHL repeat	220..261	CDD:271331	10/47 (21%)
		NHL 4	250..303		15/52 (29%)
		NHL repeat	263..316	CDD:271331	15/52 (29%)
		NHL 5	304..352		10/58 (17%)
		NHL repeat	324..356	CDD:271331	6/42 (14%)
		NHL 6	353..396		8/42 (19%)
		NHL repeat	367..393	CDD:271331	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010