DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brat and trim3

DIOPT Version :9

Sequence 1:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_031753313.1	Gene:	trim3 / 100497041	XenbaseID:	XB-GENE-5826034	Length:	790	Species:	Xenopus tropicalis

Alignment Length:	816	Identity:	201/816 - (24%)
Similarity:	334/816 - (40%)	Gaps:	187/816 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 QQQQLLPAQPMSQLSK----IVLAAAAQANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRH 331
            :|..:||.:.:|.|..    ..|....|.:.:..::|.|:..|        :.|:....|.||.|
Frog   107 RQTSILPEKGVSALQNNFFITNLMEVLQRSPESGRQEQSVLPS--------EGQEAGTPLSCPNH 163

  Fly   332 KQELLKFSCRTCCILVCKEC---------------IVLEHSTGL-HELENVQS--PGMTTSTGST 378
            :.:.:::.|..|...:|.||               :|.:|...| ::||:::|  |.:|
Frog   164 QGKTMEYYCGPCETAMCVECTEGEHREHCTVPLRDVVEQHKASLRNQLESIRSRIPQLT------ 222

  Fly   379 ANESALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELLK 443
               ||:. |::|:..::.|                 :...|.||:....:.....|.:||:.||:
Frog   223 ---SAID-LVSDISRQLSE-----------------RKNSAVNEICSAFEELEKALQQRKSALLQ 266

  Fly   444 ELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVERSPAPPSSLLTEALLLRKSLEQQLQT---- 504
            :||.:...|.....|.....|..:|...::....|::....|.  ||.||:||.:.::|..
Frog   267 DLEAICVGKQKVLQSQLSSLRQGLDNMESSVRFTEQALGHGSE--TEVLLVRKQMSERLNELAAR 329

  Fly   505 --GIQEMQLPFEIEFMSNYQSIQAGVRNTFGYIRAN--SSDGGPTGMSLTSNGHGKQPPIARPTQ 565
              .:...|.| ::||....:.::..::|....:..|  :.....||..|.....|:|..:...|:
Frog   330 DFPLHPQQNP-QLEFRVETEGLRRSLQNLGALLTTNAVAYASVATGEGLRQALVGQQTSVTVTTK 393

  Fly   566 S-------ASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLD 623
            .       :.|::..:..:|..|..|:    |....::...::.|..        |.:.|..||
Frog   394 DMDGELVRSGNATLKAQITGPDGGAQE----GEVTDNKNGTYEVLYT--------LRVEGEHLL- 445

  Fly   624 SSSSAGGAVGAFSNGGLLLGGRDRNALAVEQHFGELMPKRGGGGYTGSNGSATSAVAHYNPYEKW 688
                           .|.|.|:               |.||                  :||.
Frog   446 ---------------SLRLYGQ---------------PLRG------------------SPYR-- 460

  Fly   689 SNGGSDNLFSSVTSGVSGSSAVADAFASLSAVGGSVVSGAGA--GGSTVSSESLLDLTNKLLSAT 751
                    ..::..|        |...|...|...|.|.:|.  ....|...|.:..|||
Frog   461 --------VRAIKPG--------DVPPSPEDVKRRVKSPSGGHIRQKAVRRPSSMYSTNK----- 504

  Fly   752 IYPPKSQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFKFQ 816
               .|......:||  .:.|..|..:|:|:...|::.:..|.|:|||:||..||:|..:|:||.:
Frog   505 ---KKENPIEDEMI--LRVGSRGRDKGEFSNLQGISASCNNRIVVADSNNQCIQVFTNDGQFKLR 564

  Fly   817 FGECGKRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGATILQHPRGVTVDN 881
            ||..|:...||..|..|||..| |||||.:.. ...:.|::..|:|..|.|...|..|:||.||.
Frog   565 FGVRGRSPGQLQRPTGVAVDMN-GDIIVADYD-NRWVSIFSPEGKFKNKIGVGRLMGPKGVAVDR 627

  Fly   882 KGRIIVVECKVMRVIIFDQNGNVLHKFGC----SKH----LEFPNGVVVNDKQEIFISDNRAHCV 938
            .|.:|||:.|...:.||..||.::.:||.    .|.    |:.|:.|.||:|.||.::|...|.|
Frog   628 NGHLIVVDNKSCCIFIFQSNGKLVGRFGARGPGDKQQPGALDGPHFVAVNNKNEIVVTDFHNHSV 692

  Fly   939 KVFNYEGQYLRQIG----GEGITNYPIGVGINSNGEILIADNHNNFNLTIFTQDGQLISALES-- 997
            ||::.:|::|.:.|    |.|..|.|.||.::|||.|::|| ..|..:.:|...|..:|.:.:
Frog   693 KVYSADGEFLYKFGSHGEGNGQFNAPTGVAVDSNGNIIVAD-WGNSRIQVFDSSGSFLSYINTMG 756

  Fly   998 -KVKHAQCFDVALMDDGSVVLA-SKDYRLYIYRYVQ 1031
             .:...|  .:||..:|.||:| |.::...:|||:|
Frog   757 DPLYGPQ--GLALTSEGHVVVADSGNHCFKVYRYLQ 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	BBOX	176..222	CDD:197662
		zf-B_box	328..366	CDD:279037	13/53 (25%)
		NHL_brat_like	760..1030	CDD:271329	100/285 (35%)
		NHL repeat	783..819	CDD:271329	15/35 (43%)
		NHL repeat	830..871	CDD:271329	15/40 (38%)
		NHL repeat	874..910	CDD:271329	15/35 (43%)
		NHL repeat	914..954	CDD:271329	16/43 (37%)
		NHL repeat	959..997	CDD:271329	13/37 (35%)
		NHL repeat	1002..1027	CDD:271329	8/25 (32%)
trim3	XP_031753313.1	RAD18	54..>150	CDD:227719	10/50 (20%)
		RING_Ubox	63..107	CDD:418438	201/816 (25%)
		Bbox2_TRIM3_C-VII	154..198	CDD:380883	9/43 (21%)
		BBC	203..328	CDD:128778	35/153 (23%)
		IG_FLMN	369..463	CDD:214720	24/164 (15%)
		NHL_TRIM2_like	513..790	CDD:271330	101/283 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050