DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN6-p27 and DCTN6

DIOPT Version :9

Sequence 1:	NP_609949.1	Gene:	DCTN6-p27 / 35195	FlyBaseID:	FBgn0086446	Length:	185	Species:	Drosophila melanogaster
Sequence 2:	NP_006562.1	Gene:	DCTN6 / 10671	HGNCID:	16964	Length:	190	Species:	Homo sapiens

Alignment Length:	175	Identity:	83/175 - (47%)
Similarity:	116/175 - (66%)	Gaps:	4/175 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SENRIKILPKAVVCEESSLRGDITFSSGCVVHPSATVIADAGPIIIGENCIIEEYATVAHRLEPG 67
            ::..:||.|.||||.||.:|||:|.....|:||.|.:||:||||:|||..:|||.|.:.:.....
Human     5 TQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDN 69

  Fly    68 AVWDVNN----ILSIGTHNVFEVGCQVEAAKIGDKNVFESKCYVGPGVTVSSGCVVGAGIKIHGS 128
            ...|..:    .:.|||:|||||||..:|.|:||.||.|||.|||..|.::|||::||...::..
Human    70 ITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTF 134

  Fly   129 QRLPENTIVYGEQGLQREAIDKQGSQTLQIDFLRKVLPNYHHLRK 173
            :.:||||::||...|:|...::...||||:|||.|:|||||||:|
Human   135 EVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKK 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN6-p27	NP_609949.1	LbH_Dynactin_6	8..173	CDD:100052	82/168 (49%)
DCTN6	NP_006562.1	LbH_Dynactin_6	10..179	CDD:100052	82/168 (49%)
DCTN6	NP_006562.1	RGD motif	24..26		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147519
Domainoid	1	1.000	83	1.000	Domainoid score	I8386
eggNOG	1	0.900	-	-		E1_KOG4042
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4792
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4100
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55965
OrthoDB	1	1.010	-	-		D1278795at2759
OrthoFinder	1	1.000	-	-		FOG0005451
OrthoInspector	1	1.000	-	-		oto90006
orthoMCL	1	0.900	-	-		OOG6_104025
Panther	1	1.100	-	-	LDO	PTHR13072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2477
SonicParanoid	1	1.000	-	-		X3876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800