DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AsnRS and nars1

DIOPT Version :9

Sequence 1:	NP_001260561.1	Gene:	AsnRS / 35194	FlyBaseID:	FBgn0086443	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_696748.4	Gene:	nars1 / 568332	ZFINID:	ZDB-GENE-030131-1016	Length:	603	Species:	Danio rerio

Alignment Length:	558	Identity:	395/558 - (70%)
Similarity:	475/558 - (85%)	Gaps:	2/558 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPADQLAELTLGAIFTSEKKGSDESGDGSESKPFKTILQAMRHAGKEPFPTIYVDTKDPNAAEPY 65
            |..:.:.::::..::.|:|:|||..|||||.|||||.|:|:..|||||||.||||::  ...|.:
Zfish    48 MADEGVGKMSIKELYVSDKQGSDADGDGSEQKPFKTPLKALLFAGKEPFPVIYVDSQ--KEGERW 110

  Fly    66 EPAAKSQLKKIQKLFVRESHKNADKLQREAEDAEKRQQNLEDARKVKISEDPSLPVARKIRIYEG 130
            ...:|:|:|..:|.|.||..||..|.::||||||:|::|||:|:|:.|..|.|||..:.::|.:.
Zfish   111 TVISKTQMKNTKKAFHREQMKNESKDKKEAEDAERREKNLEEAKKITIENDSSLPEPKTVKIDKL 175

  Fly   131 TANRDSRVKVYGWVHRLRRQGKSLIFITLRDGTGFLQCVLNDQLCQTYDALTLSTESSVVLFGTL 195
            .|.|:.||||:|||||||||||:|:||.||||||||||||.|:|||.|:.|.|||||||.|:||:
Zfish   176 EALREQRVKVFGWVHRLRRQGKNLLFIVLRDGTGFLQCVLTDKLCQCYNGLVLSTESSVALYGTV 240

  Fly   196 KLVPEGKTAPGGHELNVDYWELIGLAPPGGADAILNEEAQPDVQLDNRHIMIRGENTSKVLKMRS 260
            |.|||||.|||||||:.|:|||:||||.||||.:||||:..||||:|||:||||||.||:||:||
Zfish   241 KPVPEGKQAPGGHELHCDFWELVGLAPAGGADNLLNEESDVDVQLNNRHMMIRGENVSKILKVRS 305

  Fly   261 VVTQAFRGHYEARGYNEVTPPTLVQTQVEGGSTLFKLKYFGEEAYLTQSSQLYLETCLPALGDVF 325
            .|||.||.|:.:|||.|:|||||||||||||||||.|.||||.||||||||||||||:|||||.|
Zfish   306 AVTQCFRDHFFSRGYCEITPPTLVQTQVEGGSTLFGLNYFGENAYLTQSSQLYLETCIPALGDTF 370

  Fly   326 TISQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLDRLEDLVCDVVDRVLKSPWGYLVKELNPD 390
            .|:||||||||||||||:||||:||||||::::|||:|||||||||||||||||...|:.::|||
Zfish   371 CIAQSYRAEQSRTRRHLSEYTHIEAECPFMSYEDLLNRLEDLVCDVVDRVLKSPAAPLLYDINPD 435

  Fly   391 FKPPQKPFRRMNYEDAIKWLKENNVTKDDGTFYEFGEDIPEAPERKMTDTINEPIMLCRFPAEIK 455
            ||||::||:||||.:||.||||:|:.|||||||||||||||||||.|||:|||.|:|||||||||
Zfish   436 FKPPKRPFKRMNYTEAIDWLKEHNIKKDDGTFYEFGEDIPEAPERLMTDSINETILLCRFPAEIK 500

  Fly   456 SFYMQRCKEDQRLTESVDVLLPNVGEIVGGSMRIYDSEELLKGYKREGIDPQPYYWYTDQRVYGT 520
            |||||||.||:|||||||||:|||||||||||||:||:|||:|||||||||.|||||||||.:||
Zfish   501 SFYMQRCPEDRRLTESVDVLMPNVGEIVGGSMRIWDSDELLEGYKREGIDPTPYYWYTDQRKFGT 565

  Fly   521 MPHGGYGLGLERFLCWLLNRYHIREVCLYPRFLDRCRP 558
            .|||||||||||||.|||||:|||:|||||||:.||||
Zfish   566 CPHGGYGLGLERFLTWLLNRHHIRDVCLYPRFIQRCRP 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AsnRS	NP_001260561.1	AsnS	122..558	CDD:223096	336/435 (77%)
		AsnRS_cyto_like_N	137..219	CDD:239818	63/81 (78%)
		AsxRS_core	233..552	CDD:238399	255/318 (80%)
nars1	XP_696748.4	AsnS	168..603	CDD:223096	336/434 (77%)
		AsnRS_cyto_like_N	182..264	CDD:239818	63/81 (78%)
		AsxRS_core	280..599	CDD:238399	256/318 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596861
Domainoid	1	1.000	550	1.000	Domainoid score	I249
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68404
Inparanoid	1	1.050	834	1.000	Inparanoid score	I435
OMA	1	1.010	-	-		QHG62167
OrthoDB	1	1.010	-	-		D1056670at2759
OrthoFinder	1	1.000	-	-		FOG0005762
OrthoInspector	1	1.000	-	-		oto38836
orthoMCL	1	0.900	-	-		OOG6_103052
Panther	1	1.100	-	-	LDO	PTHR22594
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1451
SonicParanoid	1	1.000	-	-		X4153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840