DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AsnRS and nars2

DIOPT Version :9

Sequence 1:	NP_001260561.1	Gene:	AsnRS / 35194	FlyBaseID:	FBgn0086443	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_021337111.1	Gene:	nars2 / 561673	ZFINID:	ZDB-GENE-060929-596	Length:	505	Species:	Danio rerio

Alignment Length:	539	Identity:	151/539 - (28%)
Similarity:	242/539 - (44%)	Gaps:	91/539 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PAAKSQLKKIQKLFVRESHKNADKLQREAEDAEKRQQNLEDARKVKISEDPSLPVARKIRIYEGT 131
            ||..|      .||.|.|.|..|:|                         .|..:::|:|:.:..
Zfish     9 PAFSS------SLFCRCSSKFLDRL-------------------------CSRMISKKMRVSDAL 42

  Fly   132 ANRD--SRVKVYGWVHRLRRQGKSLIFITLRDGTGF--LQCVLNDQLCQTYDALTLSTESSVVLF 192
            |.::  |.|::.|||..:|.| |..:|:.|.||:..  ||.|.:.|| .|.|   |:...:|.:.
Zfish    43 ACKETGSDVRIQGWVRSVRPQ-KDNLFLHLNDGSSLQPLQVVASSQL-NTRD---LTFGCAVDIT 102

  Fly   193 GTLKLVPEGKTAPGGHELNVDYWELIGLAPPGGADAILNEEAQPDVQLDNRHIMIRGENTSKVLK 257
            |||:..|..:.   ..||.....:::|...|......:.|....:......|:..|....|.:|:
Zfish   103 GTLEKSPNKRQ---NVELQAQSIKVVGECNPMDFPFKIKERHPLEYIRQFPHLRCRTNAFSSMLR 164

  Fly   258 MRSVVTQAFRGHYEARGYNEVTPPTLVQTQVEGGSTLFKLK------------YFGEEAYLTQSS 310
            :||..|.|.:..:...||.::..|.:.....||...||:::            :|...||||.|.
Zfish   165 IRSEATAAIQSFFRDHGYVQIHTPVITSNDCEGAGELFQVEPTGDKKDSDDPHFFSVPAYLTVSG 229

  Fly   311 QLYLETC--------------------LPALGDVFTISQSYRAEQSRTRRHLAEYTHVEAECPFL 355
            ||:||..                    |.|...|:|...::|||.|::||||||:..||||..|.
Zfish   230 QLHLEVMAGMFYWNLIPHGERKDMHDPLSAFSAVYTFGPTFRAENSQSRRHLAEFYMVEAEIAFT 294

  Fly   356 -TFDDLLDRLEDLVCDVVDRVLKS---PWGYLVKELNPDFKPPQKP-----FRRMNYEDAIKWLK 411
             :.|||:..:|||.....:.|..:   ......|.:.|..:....|     |..::|.:||..||
Zfish   295 ESLDDLMKVMEDLFKAATEHVFSNCTEDVELFHKHVAPGHREQVDPMLNRKFNVISYTEAIDILK 359

  Fly   412 ENNVTKDDGTFY-EFGEDIPEAPERKMTDTI-NEPIMLCRFPAEIKSFYMQRCKEDQRLT-ESVD 473
            .::   .:.||. |:|.|:....|:.:.... |.|:.:..:|.|:|.||.:..::..|.| .:||
Zfish   360 SSS---QNFTFSPEWGCDLQTEHEKFLVKHCGNTPVFVVNYPYELKPFYARDNQDHPRHTAAAVD 421

  Fly   474 VLLPNVGEIVGGSMRIYDSEELLKGYKREGIDPQPYYWYTDQRVYGTMPHGGYGLGLERFLCWLL 538
            :|:|.|||:.|||:|......|.:...:.|:: ..|.||...|.:|::||||:|:|.||:|..:|
Zfish   422 LLVPGVGELCGGSLREERLHLLTQRLSQAGLE-DTYAWYLQLREFGSVPHGGFGMGFERYLQCIL 485

  Fly   539 NRYHIREVCLYPRFLDRCR 557
            ...:|::...:.||...|:
Zfish   486 GLNNIKDAIPFARFSHSCQ 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AsnRS	NP_001260561.1	AsnS	122..558	CDD:223096	140/484 (29%)
		AsnRS_cyto_like_N	137..219	CDD:239818	26/83 (31%)
		AsxRS_core	233..552	CDD:238399	104/362 (29%)
nars2	XP_021337111.1	asnC	34..502	CDD:235176	139/479 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1056670at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920