DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AsnRS and Nars1

DIOPT Version :9

Sequence 1:	NP_001260561.1	Gene:	AsnRS / 35194	FlyBaseID:	FBgn0086443	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_006254906.1	Gene:	Nars1 / 291556	RGDID:	1307238	Length:	559	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	388/552 - (70%)
Similarity:	469/552 - (84%)	Gaps:	2/552 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AELTLGAIFTSEKKGSDESGDGSESKPFKTILQAMRHAGKEPFPTIYVDTKDPNAAEPYEPAAKS 71
            |::.|..::.|:::|:|.:|||::.|||||.|:|:...|||||||||||::..|  |.::..:||
  Rat    10 ADMVLAELYVSDREGNDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKEN--ERWDVISKS 72

  Fly    72 QLKKIQKLFVRESHKNADKLQREAEDAEKRQQNLEDARKVKISEDPSLPVARKIRIYEGTANRDS 136
            |:|.|:|::.||..|:..:.::||||..:|::|||:|:|:.|..|||||....::|......|..
  Rat    73 QMKNIKKMWHREQMKSDSREKKEAEDNLRREKNLEEAKKIIIKNDPSLPEPACVKISALEGYRGQ 137

  Fly   137 RVKVYGWVHRLRRQGKSLIFITLRDGTGFLQCVLNDQLCQTYDALTLSTESSVVLFGTLKLVPEG 201
            ||||:|||||||||||:|:|:.||||||:|||||:|.|||.|:.:.|||||||.::|||.|.|:|
  Rat   138 RVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLSDDLCQCYNGVVLSTESSVAVYGTLNLTPKG 202

  Fly   202 KTAPGGHELNVDYWELIGLAPPGGADAILNEEAQPDVQLDNRHIMIRGENTSKVLKMRSVVTQAF 266
            |.|||||||:.|:|||:||||.||||.::|||:..||||:|||:||||||.||:||.||::|:.|
  Rat   203 KQAPGGHELSCDFWELVGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMITRCF 267

  Fly   267 RGHYEARGYNEVTPPTLVQTQVEGGSTLFKLKYFGEEAYLTQSSQLYLETCLPALGDVFTISQSY 331
            |.|:..|||.|||.|||||||||||:|||||.||||||:||||||||||||||||||||.|:|||
  Rat   268 RDHFFDRGYCEVTTPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSY 332

  Fly   332 RAEQSRTRRHLAEYTHVEAECPFLTFDDLLDRLEDLVCDVVDRVLKSPWGYLVKELNPDFKPPQK 396
            |||||||||||||:||||||||||||:|||.|||||||||||||||||...:|.:|||:||.|::
  Rat   333 RAEQSRTRRHLAEFTHVEAECPFLTFEDLLSRLEDLVCDVVDRVLKSPVASIVYDLNPNFKAPKR 397

  Fly   397 PFRRMNYEDAIKWLKENNVTKDDGTFYEFGEDIPEAPERKMTDTINEPIMLCRFPAEIKSFYMQR 461
            |||||||.|||:||:|::|.|:||||||||:||||||||.|||||||||:|||||.|||||||||
  Rat   398 PFRRMNYSDAIEWLREHDVKKEDGTFYEFGDDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQR 462

  Fly   462 CKEDQRLTESVDVLLPNVGEIVGGSMRIYDSEELLKGYKREGIDPQPYYWYTDQRVYGTMPHGGY 526
            |.||.|||||||||:||||||||||||.:||||:|:|||||||||.|||||||||.|||.|||||
  Rat   463 CPEDPRLTESVDVLMPNVGEIVGGSMRSWDSEEILEGYKREGIDPAPYYWYTDQRKYGTCPHGGY 527

  Fly   527 GLGLERFLCWLLNRYHIREVCLYPRFLDRCRP 558
            ||||||||.|:|||||||:||||||||.||||
  Rat   528 GLGLERFLSWILNRYHIRDVCLYPRFLQRCRP 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AsnRS	NP_001260561.1	AsnS	122..558	CDD:223096	333/435 (77%)
		AsnRS_cyto_like_N	137..219	CDD:239818	58/81 (72%)
		AsxRS_core	233..552	CDD:238399	258/318 (81%)
Nars1	XP_006254906.1	AsnS	136..559	CDD:223096	331/422 (78%)
		AsnRS_cyto_like_N	138..220	CDD:239818	58/81 (72%)
		AsxRS_core	236..555	CDD:238399	259/318 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354542
Domainoid	1	1.000	547	1.000	Domainoid score	I249
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68404
Inparanoid	1	1.050	816	1.000	Inparanoid score	I449
OMA	1	1.010	-	-		QHG62167
OrthoDB	1	1.010	-	-		D1056670at2759
OrthoFinder	1	1.000	-	-		FOG0005762
OrthoInspector	1	1.000	-	-		oto97325
orthoMCL	1	0.900	-	-		OOG6_103052
Panther	1	1.100	-	-	LDO	PTHR22594
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4153
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770