DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AsnRS and nrs1

DIOPT Version :9

Sequence 1:	NP_001260561.1	Gene:	AsnRS / 35194	FlyBaseID:	FBgn0086443	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_595125.1	Gene:	nrs1 / 2540046	PomBaseID:	SPBC1773.10c	Length:	568	Species:	Schizosaccharomyces pombe

Alignment Length:	557	Identity:	295/557 - (52%)
Similarity:	384/557 - (68%)	Gaps:	21/557 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTSEKKGSDESGDGSESKPFKTILQAMRHAGKEPFPTIYVDTKDPNAAEPYEPAAKSQLKKIQKL 79
            :..|..|:||:|:||::.||||.:.|:.   .:...||:|   ..|.:|.:||...:.|||.:|.
pombe    20 YIDEASGNDETGNGSQTSPFKTAIHALE---TDANCTIFV---KKNGSEEFEPITTNALKKAKKG 78

  Fly    80 FVRESHKNADKLQREAEDA-------EKRQQNLEDARKVKISEDPSLPVARKIRIYEGTANRDSR 137
            ..:.:.|.|...:.||..|       |...:.||.|:.:.:.|....|.|:||.|.:.|..||||
pombe    79 VEQAAKKKAKAAEAEAAAAARAAAAKEAEAKRLEAAKNIVLKEPKDAPAAKKIAIIDSTNFRDSR 143

  Fly   138 VKVYGWVHRLRRQGKSLIFITLRDGTGFLQCVLNDQLCQ--TYDALTLSTESSVVLFGTLKLVPE 200
            |:|.|||||:|.| |.:|||.||||||||||||:.::..  :||.:.|..||:|.|:|.:|.:||
pombe   144 VRVNGWVHRMRTQ-KGIIFIILRDGTGFLQCVLSGKVYDRASYDFINLGPESTVCLYGVIKELPE 207

  Fly   201 GKTAPGGHELNVDYWELIGLAPPGGADAI---LNEEAQPDVQLDNRHIMIRGENTSKVLKMRSVV 262
            ||:|||.|||.|||::::..||. |.:|.   ||.||:|...||.||::||||..|.|||:|:..
pombe   208 GKSAPGNHELVVDYYQILHAAPT-GEEAFTNRLNAEAEPSYLLDQRHLVIRGETASSVLKVRARA 271

  Fly   263 TQAFRGHYEARGYNEVTPPTLVQTQVEGGSTLFKLKYFGEEAYLTQSSQLYLETCLPALGDVFTI 327
            .:|.|..:|.....|||||.:||||||||:||||..|:|::||||||||||||..|||||.|:||
pombe   272 LRAMRDTFENLKMTEVTPPCMVQTQVEGGATLFKFNYYGQDAYLTQSSQLYLEAALPALGSVYTI 336

  Fly   328 SQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLDRLEDLVCDVVDRVLKSPWGY-LVKELNPDF 391
            .:|:|||:|.|||||:|:||||.|.||:.|.:.|:.:|:.:|..:||:|..|... |:|:|||||
pombe   337 QESFRAEKSLTRRHLSEFTHVEFELPFVNFGEFLEIIEEFICQTIDRLLDDPIATPLIKQLNPDF 401

  Fly   392 KPPQKPFRRMNYEDAIKWLKENNVTKDDGTFYEFGEDIPEAPERKMTDTINEPIMLCRFPAEIKS 456
            ..|.:||.|::||||||:|.|:|:...:|..::||:||.||.||||||.||.||.|..||.||||
pombe   402 VKPSRPFMRLSYEDAIKYLNEHNILTPEGEQHKFGDDIAEAAERKMTDQINRPIFLTYFPLEIKS 466

  Fly   457 FYMQRCKEDQRLTESVDVLLPNVGEIVGGSMRIYDSEELLKGYKREGIDPQPYYWYTDQRVYGTM 521
            |||:|..:...||||||.|:|||||||||||||.|.:|||..||||||||.||||:|:||.|||.
pombe   467 FYMKRVVDRPELTESVDCLMPNVGEIVGGSMRISDIQELLAAYKREGIDPAPYYWFTEQRKYGTT 531

  Fly   522 PHGGYGLGLERFLCWLLNRYHIREVCLYPRFLDRCRP 558
            .|||.||||||||.||.:||.:||.||:|||.:||.|
pombe   532 EHGGCGLGLERFLAWLCDRYTVRECCLFPRFTERCTP 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AsnRS	NP_001260561.1	AsnS	122..558	CDD:223096	260/441 (59%)
		AsnRS_cyto_like_N	137..219	CDD:239818	48/83 (58%)
		AsxRS_core	233..552	CDD:238399	194/319 (61%)
nrs1	NP_595125.1	AsnS	128..568	CDD:223096	260/441 (59%)
		AsnRS_cyto_like_N	143..226	CDD:239818	48/83 (58%)
		AsxRS_core	242..563	CDD:238399	195/320 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	401	1.000	Domainoid score	I106
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68404
Inparanoid	1	1.050	570	1.000	Inparanoid score	I178
OMA	1	1.010	-	-		QHG62167
OrthoFinder	1	1.000	-	-		FOG0005762
OrthoInspector	1	1.000	-	-		oto101373
orthoMCL	1	0.900	-	-		OOG6_103052
Panther	1	1.100	-	-	LDO	PTHR22594
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1451
SonicParanoid	1	1.000	-	-		X4153
TreeFam	1	0.960	-	-
	14	13.860