Protein Alignment AsnRS and DARS1

DIOPT Version :9

• Sequence 1: NP_001260561.1
• Gene: AsnRS / 35194
• FlyBaseID: FBgn0086443
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_001340.2
• Gene: DARS1 / 1615
• HGNCID: 2678
• Length: 501
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 137/514 - (26%)
• Similarity: 233/514 - (45%)
• Gaps: 57/514 - (11%)

  Fly    82 RESHKNADKLQREAEDAEKRQQNLEDARKVKISEDPSLPVARKIRIYEGTANRDSRVKVYGWVHR 146
            |:|.:...::...|||..|.:..:....:.:...|..|...|.:.|.:.    |..|.|...||.
Human     8 RKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKA----DEVVWVRARVHT 68

  Fly   147 LRRQGKSLIFITLRDGTGFLQCVL------NDQLCQTYDALTLSTESSVVLFGTLKLVPE--GKT 203
            .|.:||. .|:.||.....:|.::      :.|:.:.  |..::.||.|.:.|.::.|.:  |..
Human    69 SRAKGKQ-CFLVLRQQQFNVQALVAVGDHASKQMVKF--AANINKESIVDVEGVVRKVNQKIGSC 130

  Fly   204 APGGHELNVDYWELIGLAPPG---GADAILNEEAQ----------PDVQLDNRHIMIRGENTSKV 255
            .....||:|....:|.||.|.   ..|..:..||:          .|.:||||.|.:|...:..|
Human   131 TQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAV 195

  Fly   256 LKMRSVVTQAFRGHYEARGYNEVTPPTLVQTQVEGGSTLFKLKYFGEEAYLTQSSQLYLETCLPA 320
            .:::|.:...||.....:|:.|:..|.::....|||:.:|.:.||...|||.||.|||.:.|:.|
Human   196 FRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICA 260

  Fly   321 -LGDVFTISQSYRAEQSRTRRHLAEYTHVEAECPF-LTFDDLLDRLEDLVCDVVDRVLKSPWGYL 383
             ...||:|...:|||.|.|.|||.|:..::.|..| ..:.::::.:.|.:..:. :.|:..:...
Human   261 DFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIF-KGLQERFQTE 324

  Fly   384 VKELNPDFKPPQKPFR------RMNYEDAIKWLKENNVTKDDGTFYEFGEDIPEAPERKMT---- 438
            ::.:|..|  |.:||:      |:.|.:|:..|:|..|...|       ||....|..|:.
Human   325 IQTVNKQF--PCEPFKFLEPTLRLEYCEALAMLREAGVEMGD-------EDDLSTPNEKLLGHLV 380

  Fly   439 ----DTINEPIMLCRFPAEIKSFYMQRCKEDQRLTESVDVLLPNVGEIVGGSMRIYDSEELLKGY 499
                ||  :..:|.::|..::.||......:.:.:.|.|:.:.. .||:.|:.||:|.:.|.:..
Human   381 KEKYDT--DFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRG-EEILSGAQRIHDPQLLTERA 442

  Fly   500 KREGIDPQPYYWYTDQRVYGTMPHGGYGLGLERFLCWLLNRYHIREVCLYPRFLDRCRP 558
            ...|||.:....|.|...:|..||.|.|:||||.....|..:::|:..::||...|..|
Human   443 LHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AsnRS	NP_001260561.1	AsnS	122..558	CDD:223096	128/472 (27%)
		AsnRS_cyto_like_N	137..219	CDD:239818	22/89 (25%)
		AsxRS_core	233..552	CDD:238399	96/344 (28%)
DARS1	NP_001340.2	tRNA-synt_2	3..501	CDD:332564	136/512 (27%)
		Aspartate. /evidence=ECO:0000250	251..254		2/2 (100%)
		Binding site for the 3'-end of tRNA. /evidence=ECO:0000255	411..415		0/3 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0017
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810