DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cd and GTF3C5

DIOPT Version :9

Sequence 1:	NP_609947.1	Gene:	l(2)37Cd / 35193	FlyBaseID:	FBgn0086445	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001116295.1	Gene:	GTF3C5 / 9328	HGNCID:	4668	Length:	526	Species:	Homo sapiens

Alignment Length:	526	Identity:	142/526 - (26%)
Similarity:	234/526 - (44%)	Gaps:	100/526 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IEYPGRVVNPDRMIATLGGIINVSKVLGDEVKRLALHFHPENPYNKPTFGDCTDKTGVLLSITVR 80
            :||||.|.:..:|:.||||...||::..|..|||.|:|.|::||..|...:....:.:||.|..|
Human    27 VEYPGVVRDVAKMLPTLGGEEGVSRIYADPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRIRKR 91

  Fly    81 RHKK------DKQRPPEYFVRVLGHCSRSFTFETLCDFQYLPLWSTPKSDNANAAQELTYALDQ- 138
            ..::      :......:.:.:||..|..:.|:.:.|||||.:       :..|..:.|...|:
Human    92 TRRQKGVLGTEAHSEVTFDMEILGIISTIYKFQGMSDFQYLAV-------HTEAGGKHTSMYDKV 149

  Fly   139 --LKPKNTTDLDYFKRRHSQLLALPELFTHVDTVYAGTYRID---------PSEDGQHEVLGVQS 192
              |:|:.    :.|..:...|...|.:|:.:|......||.:         |...|:: ::|:..
Human   150 LMLRPEK----EAFFHQELPLYIPPPIFSRLDAPVDYFYRPETQHREGYNNPPISGEN-LIGLSR 209

  Fly   193 KSSYDNQGVVSF--NMVDSFPTQADSQNLKRLKVKYVSDEQLALVKKLFDDCPIWTRIALQYESG 255
            .....|...|:|  ..|...|.:|.:|..:|:....|..:....::||||..|||:|.|::....
Human   210 ARRPHNAIFVNFEDEEVPKQPLEAAAQTWRRVCTNPVDRKVEEELRKLFDIRPIWSRNAVKANIS 274

  Fly   256 LTNDKLKCITPSLAFYFSNGPWRTLYVRFGYDPRKDFNSRYYQTFDFRLRFSTGLSE-FVYAKKF 319
            :..||||.:.|.:|:|...||||:|::||||||||:.:::.||..|||:|  .|:.. :..:...
Human   275 VHPDKLKVLLPFIAYYMITGPWRSLWIRFGYDPRKNPDAKIYQVLDFRIR--CGMKHGYAPSDLP 337

  Fly   320 VKQRRAANAPFAPIEDR--------VSDLVQDI--------------------------DYPY-F 349
            ||.:|:......||..:        :.||.|.:                          |..| |
Human   338 VKAKRSTYNYSLPITVKKTSSQLVTMHDLKQGLGPSGTSGARKPASSKYKLKVSLQTLRDSVYIF 402

  Fly   350 DEHKLPRSRQCMLRYCDVRMTRIQEMLEKIPTPLTGA--VCNERTGWLPPGFDAQVRQIVCASIS 412
            .|..||..||...:.||:.:..:|:::.:    ..||  .|.||.||..|....::|..:...|.
Human   403 REGALPPYRQMFYQLCDLNVEELQKIIHR----NDGAENSCTERDGWCLPKTSDELRDTMSLMIR 463

  Fly   413 ELLRNHY------------RKENLTAEVEAVTQADEEDEDEAEDEETQEEDMELDETQAMGNSEQ 465
            :.:|:..            .||.||.|       ..|||::.|:||.:|||.:..:     .||.
Human   464 QTIRSKRPALFSSSAKADGGKEQLTYE-------SGEDEEDEEEEEEEEEDFKPSD-----GSEN 516

  Fly   466 FVDNDI 471
            .::.:|
Human   517 EMETEI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cd	NP_609947.1	Tau95	13..303	CDD:286777	91/306 (30%)
GTF3C5	NP_001116295.1	Tau95	24..322	CDD:286777	91/306 (30%)
GTF3C5	NP_001116295.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..526		17/63 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147902
Domainoid	1	1.000	84	1.000	Domainoid score	I8334
eggNOG	1	0.900	-	-		E1_KOG2473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40806
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4245
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49405
OrthoDB	1	1.010	-	-		D1111142at2759
OrthoFinder	1	1.000	-	-		FOG0003593
OrthoInspector	1	1.000	-	-		oto89391
orthoMCL	1	0.900	-	-		OOG6_103019
Panther	1	1.100	-	-	LDO	PTHR13230
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1325
SonicParanoid	1	1.000	-	-		X2465
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800