DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and DHX38

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_054722.2	Gene:	DHX38 / 9785	HGNCID:	17211	Length:	1227	Species:	Homo sapiens

Alignment Length:	999	Identity:	402/999 - (40%)
Similarity:	580/999 - (58%)	Gaps:	127/999 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGKNRKRTAS--SSSSGEEPDSEEESRLKDLQE--------RD-EFASRLKKRDDDRT------- 48
            |.::|.:.|:  |.|:.||.||...|..:...|        || |.:.||..||.||:
Human   199 SPRHRPKDAATPSRSTWEEEDSGYGSSRRSQWESPSPTPSYRDSERSHRLSTRDRDRSVRGKYSD 263

  Fly    49 -----------------RNVVDST----GGRRAIEEATKRLKLEHE-------------DRDKIV 79
                             |..:.||    .||...||..:.:..:.|             |||..:
Human   264 DTPLPTPSYKYNEWADDRRHLGSTPRLSRGRGRREEGEEGISFDTEEERQQWEDDQRQADRDWYM 328

  Fly    80 P-------HLRL--------QSRRQYLEKRKDDKVAELEADILDDEYLFDES-VLTK----REKE 124
            .       |..|        :.|.|:|.|:|..:::.....|.:|...::.: :||.    |.:.
Human   329 MDEGYDEFHNPLAYSSEDYVRRREQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEV 393

  Fly   125 EREYKKQLLNIAKEHEKAREL------ERIQRYNMPQ----------DL----KKGERSEYVEVD 169
            :.::::.  |.||.|.....|      .||.....|:          ||    :||.::.....:
Human   394 DEDFEED--NAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHRE 456

  Fly   170 EFEKQPNSEQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDG-----SREKSS 229
            :.|:: .::.|.||   ||..:.. .....|.|||.:          :|:|.||     :.:|.:
Human   457 QKERK-KAQHKHWE---LAGTKLG-DIMGVKKEEEPD----------KAVTEDGKVDYRTEQKFA 506

  Fly   230 ---SRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVE 291
               .|:.|.:.:..|:.::.|.|:.||::..:::|:..::::.::|:.||||||||||:.|||.|
Human   507 DHMKRKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHE 571

  Fly   292 AGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHR 356
            .|:| |..||||||||||||||||.||:||||..||.||||:||||||||:.|::||||||.|.|
Human   572 DGYT-DYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTLIKYMTDGILLR 635

  Fly   357 EFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAP 421
            |.|.|.||..||.:|:||||||:|:||:||||::::...|.:|||:::|||:|||||:|||.:.|
Human   636 ESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVP 700

  Fly   422 IFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVK 486
            ||.||||.:||||.::|.|:.||::|.....||:|.:...||||:|:.||::||...:.:.:.::
Human   701 IFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAPGDILIFMPGQEDIEVTSDQIVEHLE 765

  Fly   487 RLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQN 551
            .| .....|.|:|:|:.||||:|||||:..|...||.|:||||||||||:|.|::|||.|:.|..
Human   766 EL-ENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLK 829

  Fly   552 NFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNA 616
            .||.|.||::|.:.|||:|:||||:||||||.||:||||||..|||:||...|||||||.||.|.
Human   830 VFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANV 894

  Fly   617 VLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKML 681
            ||:||:||:.||:.|.|:||||.:.::.::.||:.||||::.|.||..||.|.|||:||.:.|||
Human   895 VLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKML 959

  Fly   682 LASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDY 746
            :.|....||.|::.|.:|||| .|||||||.:...:|..|:.|.....|||:.|.||.||...:|
Human   960 IVSCDMGCSSEILLIVSMLSV-PAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQWKNNNY 1023

  Fly   747 STQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGG 811
            ||.||.::||..::|::.|:||.||..:|.:..:.:.||..:...|||...|.||:..|:|...|
Human  1024 STIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQAAKLKGIG 1088

  Fly   812 HYKTIKHNQTVMIHPNSSLF--EELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKE 874
            .|..|:......:||.||||  ...|.:::|||||.|:||||:.|..::.:||.|:.|.:|..|:
Human  1089 EYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAELGPMFYSVKQ 1153

  Fly   875 LEDS--TNKKMPKVAGRA---EMA 893
            ...|  .|::..|....|   |||
Human  1154 AGKSRQENRRRAKEEASAMEEEMA 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	325/654 (50%)
		DEXDc	269..408	CDD:238005	90/138 (65%)
		HELICc	491..581	CDD:197757	51/89 (57%)
		HA2	651..735	CDD:214852	40/83 (48%)
		OB_NTP_bind	770..869	CDD:285018	38/100 (38%)
DHX38	NP_054722.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..320		28/120 (23%)
		HrpA	515..1146	CDD:224557	320/633 (51%)
		DEAH box	652..655		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1155..1227		7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720