DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and Dqx1

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_291084.1	Gene:	Dqx1 / 93838	MGIID:	2136388	Length:	718	Species:	Mus musculus

Alignment Length:	668	Identity:	229/668 - (34%)
Similarity:	359/668 - (53%)	Gaps:	47/668 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 ETRRSLPVYP----FKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVE----AGFTKDKKMIGC 303
            |.||:||::.    |.|.|.::  ...|:::.|:.||||:||:||:..|    .||...:  :..
Mouse    37 EQRRALPIWAARFLFLEHLESS--PTGVVLVSGDPGSGKSTQIPQWCAEFALARGFQTGQ--VTV 97

  Fly   304 TQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYS 368
            |||..:||||:|:|||:||.:.||:|:||||..||||...|:|::..|....:|..|.....::|
Mouse    98 TQPYPLAAMSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWS 162

  Fly   369 VMIIDEAHERTLHTDILFGLVKDIARFR-----PELKLLISSATLDAEKFSAFFDDAPIFRIPGR 428
            |:|:|||.||::.:|:|.||::| .|.|     |.: ::::...|: .||.||:.::||.|:|
Mouse   163 VLILDEAQERSVASDLLQGLLRD-TRLRNLPGDPRV-VVVTDPALE-PKFQAFWGNSPIVRVP-- 222

  Fly   429 RYP---VDIFYTKAPEADYIDACCVSVLQI-HATQPLGDILVFLTGQDEIETCQEVLHDRVKRLG 489
            |.|   ..:.|......|.::|.|.:||:: ...:..||:||:|..::||..|.|.|...:..|.
Mouse   223 REPGGDPTLAYKDTVPTDLVEAACQAVLELCQQEEAPGDVLVYLPSEEEISLCCESLSGEMGTLA 287

  Fly   490 SKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFN 554
            .......|:|::......:|. ::|.|..:.||:::...:|:.|.::.:|.:|||.|...::.:|
Mouse   288 VPGPPPRVLPLHPGCAQAIQT-VYEDTDVSVRKIVVTHWLADFSFSLPSIQHVIDSGLELRSVYN 351

  Fly   555 SRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLM 619
            .|...||.::.||||..|..|..||....||.|.|||:....:.|......|::...||.:.||:
Mouse   352 PRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTLELEAPPLPHPKVCEENLSSLVLL 416

  Fly   620 LKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLAS 684
            |....|.:.....|||.|..|.|:.|||.|..|.|||..|||:.||..::|||:.|.:.|.||||
Mouse   417 LMRKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALLAS 481

  Fly   685 EKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTA--RKNFNHMHGDHLSLLQVYNQWAETDYS 747
            .::.|.:||:|:||||:.... |.||.   :.|..|  |:...|..|||.||:|||..:.::...
Mouse   482 CEFNCVDEMLTLAAMLTAAPG-FTRPP---LSAGEAALRRALEHADGDHSSLIQVYEAFVQSGAD 542

  Fly   748 TQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDM----VSCLPETVNVRKAATAGYFYHVARLS 808
            ..||....:.:.|:.:||.:|.:||.||||:|:.:    ........:::||..:|||..|||.:
Mouse   543 EAWCQARGLNWESLCQARKLRAELVELMQRIELPLSQPAFGSEQNRRDLQKALLSGYFLKVARDT 607

  Fly   809 KG-GHYKTIKHNQTVMIHP-----NSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAP 867
            .| |:|..:.|.....:.|     |.....:.|.|||||....:....:..|.||:.:.|:|:||
Mouse   608 DGTGNYLLLTHKHVAQLSPYCSYRNRRTPAQPPTWVLYHSFSISKDNCLCIVSEIQPEMLVELAP 672

  Fly   868 HYYKA----KELEDSTNK 881
            .|:.:    .|..|..|:
Mouse   673 PYFLSNLPPSESRDLLNQ 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	223/648 (34%)
		DEXDc	269..408	CDD:238005	58/147 (39%)
		HELICc	491..581	CDD:197757	26/89 (29%)
		HA2	651..735	CDD:214852	37/85 (44%)
		OB_NTP_bind	770..869	CDD:285018	34/108 (31%)
Dqx1	NP_291084.1	HrpA	9..672	CDD:224557	223/648 (34%)
		DEAQ box	167..170		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..718		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820