DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and DHX57

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_945314.1	Gene:	DHX57 / 90957	HGNCID:	20086	Length:	1386	Species:	Homo sapiens

Alignment Length:	1139	Identity:	301/1139 - (26%)
Similarity:	468/1139 - (41%)	Gaps:	336/1139 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGKNRKRTASSSSSGEEPDSEE--------------ESRLKDLQERDEFASRLKKRDDDRTRNV 51
            ::.:.||.....|:...:.:|.|              :.|.|.....::...|:::..||...|
Human   281 LTSRFRKSKPKESTKNVQENSLEICKFYLKGNCKFGSKCRFKHEVPPNQIVGRIERSVDDSHLN- 344

  Fly    52 VDSTGGRRAIEEATKRLKLE-HEDRDKIVPH----LRLQSRRQYLEKRKDDKVAELEADILDDEY 111
                    |||:|:...:|| ...:|...|:    :...|..:.|         .|...:...|:
Human   345 --------AIEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENL---------PLACRLHISEF 392

  Fly   112 LFDE-------------SVLTKREKEEREYKKQLLNIAKEHEKARE-------LERIQRYNMP-- 154
            |:|:             |::|..| ||.|..|.|.|   .|.|..:       :....|.|.|
Human   393 LYDKALTFAETSEPVVYSLITLLE-EESEIVKLLTN---THHKYSDPPVNFLPVPSRTRINNPAC 453

  Fly   155 ---------------QDLKKGERSEYVEVD--------EFEKQPNSEQKKWEAEQLASARFHFGA 196
                           .:::|...||..:.|        |.|...|.::|       .|.|:.:.|
Human   454 HKTVIPNNSFVSNQIPEVEKASESEESDEDDGPAPVIVENESYVNLKKK-------ISKRYDWQA 511

  Fly   197 KDAKAEEEYELLLDDQIDFIQALTLDGS-----REKSSSRQPELTEKERKRLTLDETRRSLPVYP 256
            |...||                   :|.     |.|.:|||.:         ::.:.|:|||.:.
Human   512 KSVHAE-------------------NGKICKQFRMKQASRQFQ---------SILQERQSLPAWE 548

  Fly   257 FKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIG---CTQPRRVAAMSVAARV 318
            .:|.::..:::|||::|.|.||.|||||:||::::.......:.:.   ||||||::|:|||.||
Human   549 ERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERV 613

  Fly   319 AEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTD 383
            |:|...::|..|||.||.|...|..|.|.|.|.|.|.|....:..|...|.:|:||.||||..:|
Human   614 AKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESD 678

  Fly   384 ILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDAC 448
            .|..::|||...||.|::::.||||:||.||.:|:..|:..||||.:|||.|:.:       ||.
Human   679 FLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFFLE-------DAI 736

  Fly   449 CVS--VLQ------------------------------------IHA------------------ 457
            .|:  |||                                    :|.
Human   737 AVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFK 801

  Fly   458 ------------------------------------------TQPLGDILVFLTGQDEIETCQEV 480
                                                      :.|.|.|||||.|..||:...|.
Human   802 QLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQ 866

  Fly   481 LHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDP 545
            |.........:....::.|::::|.|:.|..:|...|....|:|::|||||||:|||:::||||.
Human   867 LQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNIAETSITIDDVVYVIDS 931

  Fly   546 GFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQR 610
            |..|:..:::..|||||....:|:|:|.||.|||||.|.|.||.|:|:..|.|:|....:|||||
Human   932 GKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQR 996

  Fly   611 INLGNAVLMLKALGI----NDLIHFDFLDPPPH-ETLVLALEQLYALGALNHHGELTKLGRRMAE 670
            :.|....|.:|.|.:    |....|..|..||| ::|..:..:|..||||.....||.||..:|.
Human   997 VPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGALTPDERLTPLGYHLAS 1061

  Fly   671 FPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLL 735
            .|||..:||::|....::|.:..:||||.|:..|. |..|.||...|:..:..|...:.|:|:||
Human  1062 LPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSP-FVSPWDKKEEANQKKLEFAFANSDYLALL 1125

  Fly   736 QVYNQW-------AETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRV----------EID-- 781
            |.|..|       ....|:  :|.:||:..|.::....::.|...|:..:          ||:
Human  1126 QAYKGWQLSTKEGVRASYN--YCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKR 1188

  Fly   782 -----------------------MVSCL------PETVNVR-------KAATAGYFYHVARLSKG 810
                                   ::|.:      |..|.|:       |.:|..    |....|.
Human  1189 AQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGA----VRMQPKS 1249

  Fly   811 GHYKTI-KHNQTVMIHPNSSLFE----ELPRWVLYHELVFTSKEYMRQ----------------- 853
            ...|.: |::..|.|||:|..::    :.| ::||||.:.||:.::|.
Human  1250 AELKFVTKNDGYVHIHPSSVNYQVRHFDSP-YLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQV 1313

  Fly   854 ---------VIEIESKWLLEVAPHYYKA---KEL 875
                     |:.::..|:..||..:..|   |||
Human  1314 NVQLQRGEFVVSLDDGWIRFVAASHQVAELVKEL 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	243/841 (29%)
		DEXDc	269..408	CDD:238005	61/141 (43%)
		HELICc	491..581	CDD:197757	37/89 (42%)
		HA2	651..735	CDD:214852	30/83 (36%)
		OB_NTP_bind	770..869	CDD:285018	31/177 (18%)
DHX57	NP_945314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..147
		UBA_DHX57	181..218	CDD:270502
		RWD	243..418	CDD:283440	28/155 (18%)
		ZnF_C3H1	303..323	CDD:214632	2/19 (11%)
		DEXDc	550..730	CDD:214692	78/179 (44%)
		DEXDc	561..703	CDD:238005	61/141 (43%)
		DEVH box	668..671		2/2 (100%)
		Helicase_C	832..968	CDD:278689	50/135 (37%)
		HA2	1043..1125	CDD:214852	30/82 (37%)
		OB_NTP_bind	1164..1310	CDD:285018	27/150 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810