DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and PRP16

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_013012.3	Gene:	PRP16 / 853961	SGDID:	S000001794	Length:	1071	Species:	Saccharomyces cerevisiae

Alignment Length:	947	Identity:	349/947 - (36%)
Similarity:	538/947 - (56%)	Gaps:	122/947 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DEFASRLKKRDDDRTRNVVDSTGGRRAIEEATKR----LKLEHEDRD------------------ 76
            :|....||.:.::      ||||.::......||    ::|:.:|.:
Yeast    63 NELLELLKNKSEE------DSTGPKKIAPSINKRKKFKIQLDLDDNEDELDSPVQKKPAPTRTLF 121

  Fly    77 KIVPHLRLQSRRQYLEKRKD------DKVAELEADILDDEYLFDESVLTKREKEEREY------- 128
            |.:..|:.:..|||....||      .:.....|:..|.|....|.|     :|:||:
Yeast   122 KRIDKLKAKQLRQYSPTVKDPSPNSEQQTQNGHAETKDYEPTRSEVV-----EEDREWYDNDDDY 181

  Fly   129 -------------KKQLLNIAKEHEKARELER-IQRYNMPQDLKKGERSEYV------------- 166
                         :.:||.:.:..:....|.. :|.|.:|  ||  :|.|::
Yeast   182 GNLVPEPLSELPEEAKLLPVIRNIDNDDALRNTVQLYPIP--LK--QRMEWIPPFLSKFALENKV 242

  Fly   167 -------EVDEFEKQ------------PNSE---QKKWEAEQLASARFHFGAKDAKAEEEYELLL 209
                   .:.|...|            |:||   ..|..::.:|..|.:.  :..:...:...:|
Yeast   243 PTSIIIGSISETSSQVSALSMVNPFRNPDSEFSANAKRGSKLVALRRINM--EHIQQSRDNTTVL 305

  Fly   210 DDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDE---TRRSLPVYPFKEDLIAAVKEHQVL 271
            :..:..:..|. :.::.|..|.|....:......:.|:   |:..|||:..:..|::.::|:||:
Yeast   306 NTAMGEVLGLE-NNNKAKDKSNQKICDDTALFTPSKDDIKHTKEQLPVFRCRSQLLSLIRENQVV 369

  Fly   272 IIEGETGSGKTTQVPQYLVEAGFTKDK-KMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIR 335
            :|.||||||||||:.|||.|.|:..|: |.|..||||||||:|||.|||.||.|.||.|||||||
Yeast   370 VIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAISVAKRVAMEMQVPLGKEVGYSIR 434

  Fly   336 FEDCT-SDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPEL 399
            |||.| |:.|.||::|||.|.||.|.:..|..||.:||||||||:|:||||.|..|.:...|.:|
Yeast   435 FEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDL 499

  Fly   400 KLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPL--G 462
            ||:|:|||::|:||||||.:||.|.||||.:||...||..|..||::|.....::||.....  |
Yeast   500 KLIITSATMNAKKFSAFFGNAPQFTIPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIHLANDCSSG 564

  Fly   463 DILVFLTGQDEIETCQEVLHDRVKRLGSK---------IRELIVIPVYANLPSDMQAKIFEPTPP 518
            |||:|:|||::|||..:.|.::..::.||         |.::.::|:|:.||:|:|.|||:....
Yeast   565 DILIFMTGQEDIETTFDTLQEKFLQVYSKKFGTANFEEINDIEILPIYSALPADLQFKIFQDLHG 629

  Fly   519 NARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTA 583
            ..||:|:|||||||||||..|.||||.|::|...:|.:.|::||::.|||||:|:||:|||||||
Yeast   630 TKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLVITPISKANADQRSGRAGRTA 694

  Fly   584 PGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGIND-LIHFDFLDPPPHETLVLALE 647
            ||..:||||...:|.::...|:|||||.||.|.:|:||:|.:.| |..|.|:|.||.:|.:.:|.
Yeast   695 PGTAYRLYTEDTFKEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDELSKFPFIDKPPLQTFLSSLY 759

  Fly   648 QLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKD 712
            :|:.:||::..|:||.||.:||:||:.|.:.|:||.:.:..||:||:||.:|||| ..:|||||:
Yeast   760 ELWFIGAIDTSGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSV-PQVFYRPKE 823

  Fly   713 KIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQR 777
            :...||.||..|.....|||:||.|:.||...::|:.||.::|:||:|:.||||:|:||:.:::.
Yeast   824 RQKEADIARNKFFIAKSDHLTLLNVFEQWRANNFSSHWCNKHFVQYKSLVRARDIRDQLLTILKS 888

  Fly   778 VEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSL--FEELPRWVLY 840
            .:|.::|...:...::|...:|:.:..|:::...:|..:|...:|.:||.|:|  ..:||.:|:|
Yeast   889 QKIPVISSGKDWDIIKKCICSGFAHQAAKITGLRNYVHLKTGVSVQLHPTSALHGLGDLPPYVVY 953

  Fly   841 HELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKELED 877
            |||:.|||||:..|..::..||:|.....|..|.:::
Yeast   954 HELLMTSKEYICCVTSVDPFWLMEYGGLLYDIKRIKN 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	301/663 (45%)
		DEXDc	269..408	CDD:238005	87/140 (62%)
		HELICc	491..581	CDD:197757	47/98 (48%)
		HA2	651..735	CDD:214852	38/83 (46%)
		OB_NTP_bind	770..869	CDD:285018	30/100 (30%)
PRP16	NP_013012.3	HrpA	319..1071	CDD:224557	303/673 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	5	4.710