DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and DHR2

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_012845.1	Gene:	DHR2 / 853784	SGDID:	S000001561	Length:	735	Species:	Saccharomyces cerevisiae

Alignment Length:	682	Identity:	254/682 - (37%)
Similarity:	399/682 - (58%)	Gaps:	49/682 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 DGSREKSSSRQPELTEKERKRLTLD--ETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQ 284
            |...::.|:::..||.|..|....|  :.|.:||||..|.::::.::.:.|.::.|||||||:||
Yeast    49 DHVSDQRSNKENVLTYKSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSGKSTQ 113

  Fly   285 VPQYLVEAGF-TKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKY 348
            :||:::|..: ||....|..||||||||:::|.|||:|.|.|||.:||||:||::.|:.||.|||
Yeast   114 IPQFVLEKLYDTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNTTTTRTRLKY 178

  Fly   349 MTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARF-RPELKLLISSATLDAEK 412
            :|||.|.||.:...||..|||::||||||||:.||::.|.:|.:.:. ||:|::::.||||.|||
Yeast   179 LTDGMLLRELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGPRPDLRIIVMSATLQAEK 243

  Fly   413 FSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYIDA---CCVSVLQIHATQPLGDILVFLTGQDEI 474
            ||.||::|||..:.||::.|..:|.|||..|.:||   ||:   ||:..:.|||||.||.||:||
Yeast   244 FSEFFNNAPILFVEGRKFDVKQYYLKAPTDDIVDAVIRCCI---QINQGEELGDILCFLPGQEEI 305

  Fly   475 ETCQEVLHDRVKRLGSK--IRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTID 537
            :....::....|.:..:  :..::..|:||.||:..|:.:|.|.....|||:.:|||||||:||.
Yeast   306 DKAVTIMEKIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVTIS 370

  Fly   538 NIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELED 602
            .:.:|:|.|..|...:..:.|:.:|:.||||:|||.||:|||||.:.||.||||....|. :|..
Yeast   371 GVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYV-KLPK 434

  Fly   603 NTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRR 667
            .:.|||.|.::.:.|||||..|::||:::.:.:.|..|.:|:.|::||.||||:..|::||.|::
Yeast   435 QSEPEIARSDVTSPVLMLKRYGVDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGKITKRGQQ 499

  Fly   668 MAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFY---RPKDKIIHADTARKNFNHMHG 729
            ||..|:.|.:..:|:.:.:..|..:::.|.:.|||.:.:..   ..:|::.....:..|....:|
Yeast   500 MALLPLQPHLSSVLIKASEVGCLSQVIDIVSCLSVENLLLNPSPEERDEVNERRLSLCNAGKRYG 564

  Fly   730 DHLSLLQV-----YNQWAETDYSTQ---WCYENFIQYRSMKRARDVREQLVGLMQRV-------- 778
            |.:.|.::     |......|.|::   ||....|..|..|....||:||....:|:
Yeast   565 DLIMLKELFDIYFYELGKSQDASSERNDWCKGLCISIRGFKNVIRVRDQLRVYCKRLFSSISEED 629

  Fly   779 --------EIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSLF--EE 833
                    :.:::|      .:.|....|:..:.|.......|:|:...:.:.|||:|.||  :.
Yeast   630 EESKKIGEDGELIS------KILKCFLTGFIKNTAIGMPDRSYRTVSTGEPISIHPSSMLFMNKS 688

  Fly   834 LPRWVLYHELVFTSKEYMRQVIEIESKWLLEV 865
            .| .::|.|.|||:|.|.|.|..||..||.||
Yeast   689 CP-GIMYTEYVFTTKGYARNVSRIELSWLQEV 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	254/682 (37%)
		DEXDc	269..408	CDD:238005	73/140 (52%)
		HELICc	491..581	CDD:197757	38/91 (42%)
		HA2	651..735	CDD:214852	22/86 (26%)
		OB_NTP_bind	770..869	CDD:285018	31/114 (27%)
DHR2	NP_012845.1	HrpA	30..730	CDD:224557	254/682 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810