DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and PRP43

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_011395.1	Gene:	PRP43 / 852757	SGDID:	S000003088	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	745	Identity:	346/745 - (46%)
Similarity:	478/745 - (64%)	Gaps:	86/745 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 RFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVY 255
            |.|..|::|:..|                  ||.....:.|  |.|.   |.:.:.:.||.|||:
Yeast    55 RHHTSAEEAQKLE------------------DGKINPFTGR--EFTP---KYVDILKIRRELPVH 96

  Fly   256 PFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTK----DKKMIGCTQPRRVAAMSVAA 316
            ..:::.:...:.:|:::..||||||||||:||:::   |.:    :...:.|||||||||||||.
Yeast    97 AQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVL---FDEMPHLENTQVACTQPRRVAAMSVAQ 158

  Fly   317 RVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLH 381
            ||||||.||||.|||||||||:.||::|||||||||.|.||.:.:.||:.||.:|:||||||||.
Yeast   159 RVAEEMDVKLGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLA 223

  Fly   382 TDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYID 446
            ||||.||:|.:.:.||:||::|.|||||||||..:|:|||:..:|||.|||:::||...:.||:|
Yeast   224 TDILMGLLKQVVKRRPDLKIIIMSATLDAEKFQRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLD 288

  Fly   447 ACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSK----IRE-----LIVIPVYA 502
            :...:|||||||:..||||:||||:||||       |.|:::..:    :||     |.|.|:|.
Yeast   289 SAIRTVLQIHATEEAGDILLFLTGEDEIE-------DAVRKISLEGDQLVREEGCGPLSVYPLYG 346

  Fly   503 NLPSDMQAKIFEPTPPN-----ARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESL 562
            :||...|.:||||.|.:     .|||:::|||||||||||.|:||:||||:||..:|.|..:|||
Yeast   347 SLPPHQQQRIFEPAPESHNGRPGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESL 411

  Fly   563 MVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGIND 627
            :|.|||||||.|||||||||.|||||||||..|::.||.:.:.|||.|.||.:.||.||.|||:|
Yeast   412 LVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKELIEQSYPEILRSNLSSTVLELKKLGIDD 476

  Fly   628 LIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEE 692
            |:||||:|||..||::.|||:|..|..|:..|.||.|||..::||:|||:..||:.|.:::||:|
Yeast   477 LVHFDFMDPPAPETMMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQE 541

  Fly   693 MVTIAAMLSVNSAIFYRP-KDKIIHADTARKNFNHMHGDHLSLLQVYNQWAET---DYST-QWCY 752
            ::||.|||||.: :|.|| ||| ..||.|:..|.|..|||::||.||:.:...   :|.. :||.
Yeast   542 ILTIVAMLSVPN-VFIRPTKDK-KRADDAKNIFAHPDGDHITLLNVYHAFKSDEAYEYGIHKWCR 604

  Fly   753 ENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETV----NVRKAATAGYFYHVARLSKGGH- 812
            ::::.|||:..|.::|.||..||.|..:::.:...|:.    |:|||..:|:|..||:...|..
Yeast   605 DHYLNYRSLSAADNIRSQLERLMNRYNLELNTTDYESPKYFDNIRKALASGFFMQVAKKRSGAKG 669

  Fly   813 YKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYY------- 870
            |.|:|.||.|:|||::.|..: ..||:|:|.|.|||.|:|.|..:..:||:|:||.||
Yeast   670 YITVKDNQDVLIHPSTVLGHD-AEWVIYNEFVLTSKNYIRTVTSVRPEWLIEIAPAYYDLSNFQK 733

  Fly   871 ---------------KAKELEDSTNKKMPK 885
                           :..||:...|||..|
Yeast   734 GDVKLSLERIKEKVDRLNELKQGKNKKKSK 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	331/672 (49%)
		DEXDc	269..408	CDD:238005	87/142 (61%)
		HELICc	491..581	CDD:197757	56/103 (54%)
		HA2	651..735	CDD:214852	40/84 (48%)
		OB_NTP_bind	770..869	CDD:285018	41/103 (40%)
PRP43	NP_011395.1	HrpA	55..753	CDD:224557	340/733 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	6	5.720