Protein Alignment l(2)37Cb and YLR419W

DIOPT Version :9

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_013523.3
• Gene: YLR419W / 851137
• SGDID: S000004411
• Length: 1435
• Species: Saccharomyces cerevisiae
• Alignment Length: 1145
• Identity: 275/1145 - (24%)
• Similarity: 468/1145 - (40%)
• Gaps: 335/1145 - (29%)

  Fly    23 EESRLKDLQERDEFASRLKKRDDDRTRNVVDSTGGRRAIEEATKRLKLEHEDRDKIVPH------ 81
            |:.:||..:|:::.|...:.:.:...|.::.|.||   |..:.|    :.::| |:..|
Yeast   197 EDRKLKAQREKEQVAQNNQAQKEQVARTILSSHGG---ISSSGK----DRQER-KVASHKNSHNP 253

  Fly    82 --LRL--------------QSRRQYLEKRKDDKVAELEADILDDEYLFDESVLTKREKEEREYKK 130
              :|.              :|.||.:|....:|: :.:|..:..:   :|::...||    :.|.
Yeast   254 SLVRFPKKVWENSIFVDLDESSRQLIETSLKEKI-DWQAKKISHK---NETIAENRE----DLKA 310

  Fly   131 QLLNI---AKEHEKA---RELERIQRYNMPQD-------LKKGERSEYVEV-------------- 168
            :||.:   .|..|:|   ::......:|:|:|       .|||:....||:
Yeast   311 KLLTLQFRPKHVEEAMLYKDPLSFLLFNLPEDDLPPFFHKKKGDTKNKVEITNLPLSTRMIVERL 375

  Fly   169 -------DEF-----------------------------EKQPNSEQKK---W--EAEQLASARF 192
                   ||.                             ..:|.||.:.   |  |.|.|.|. :
Yeast   376 TEIGVSSDEALLALQQNDMNENEAAGFLTREILPTLNSNTNEPVSETESIECWNQELESLESI-Y 439

  Fly   193 HFGAKDAKAEEEYELLLDDQI-------------------------------DFI--QALT---- 220
            .....|||.:..|.|.|.:::                               |:|  |.||
Yeast   440 EGCVMDAKEDSHYTLNLIEKLKIKLKVYRTKNYPASLPGIVVSTFDKNYKLPDYIKKQILTRLLH 504

  Fly   221 -------------------------------------------------LDGSR--EKSSSRQ-- 232
                                                             .:|.|  ..||||:
Yeast   505 YLQEGNLIGDMLVYHIYEWLKENISKIIDNPGPLIPDSDSKGAINKRNISNGKRSINNSSSRKFT 569

  Fly   233 ---------PELTEKERKRLTLDE------TRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKT 282
                     ..|.|:..||:...|      .|..||.:..::.:|..:.:::|::|.|||||||:
Yeast   570 KTTISEDTLSVLREEYTKRIKSSEYKSMQLVREQLPAWKKQKVIIDIINKNEVVLITGETGSGKS 634

  Fly   283 TQVPQYLVE------AGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTS 341
            |||.|::::      ..|.|.|  |.||||||::|:.:|.||::|..|..|.||||.||..:.|.
Yeast   635 TQVVQFILDFLQKEKGDFGKTK--IVCTQPRRISAIGLAERVSDERCVTCGEEVGYVIRGVNKTK 697

  Fly   342 DRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSA 406
            ..|.:|:||.|.|.|...:...:...::::|||.|||::.||::..|:|::......:|:::.||
Yeast   698 ASTRIKFMTTGVLVRLLQNARTMLENTIVVIDEVHERSIDTDLIVTLMKNLLHRVRGMKIVLMSA 762

  Fly   407 TLDAEKFSAFFDDAPIFRIPGRRYPV-DIF---------------------------------YT 437
            |::.:.|..||.......|.||.:|: |.|                                 |.
Yeast   763 TVNVDLFKKFFPGLATCHIEGRTFPITDYFLEDILSDLDFKIKREKALSYDDDSVDERNNDDQYL 827

  Fly   438 KAPEAD---------YIDACCVSVLQIH----ATQPLGDILVFLTGQDEIETCQEVLHDRVKRLG 489
            | |.||         ..|..|..|..:|    |....|.|:|||.|..||..|..:|.::
Yeast   828 K-PRADSKFFTSGQINYDLLCQVVEYVHKRLKAANDNGSIIVFLPGVGEINKCCNLLANK----- 886

  Fly   490 SKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFN 554
            |...:.:|:|:::.|..:.|.::|:.. ...|||:::|||||||:|||:.:..||.|.||...:|
Yeast   887 SNEADFMVLPLHSALTPEDQKRVFKKY-HGKRKVVVSTNIAETSITIDDCVATIDTGRAKSMFYN 950

  Fly   555 SRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLM 619
            .:.....|:...||||...||.|||||...|..::|::...|::::....:|||:||.|.:..|.
Yeast   951 PKDNTTKLIESFISKAEVKQRRGRAGRVREGLSYKLFSKNLYENDMISMPIPEIKRIPLESLYLS 1015

  Fly   620 LKALGINDLIHF--DFLDPPPHETLVLALEQLYALGALNHHGE-LTKLGRRMAEFPV-DPMMGKM 680
            :||:||.|:..|  ..||.||...|..|...|..:|.::...: ||:||:.::..|| |...||:
Yeast  1016 VKAMGIKDVKAFLSTALDAPPLPALQKAERILTTIGLVDESDKSLTQLGQFISLMPVMDSKHGKL 1080

  Fly   681 LLASEKYKCSEEMVTIAAMLSVNSAIF---YRPKDKIIHADTARKNF--NHMHGDHLSLLQV--- 737
            |:....:.|::..|.:.::|.:....|   :..::||      :|..  ....||..::|::
Yeast  1081 LIYGILFGCTDISVLLVSILGIGVLPFIGGFENREKI------KKLLCKYESRGDLFAVLEIVRD 1139

  Fly   738 YNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRV-------EIDMVSCL---PETVNV 792
            |.:..::....::..:|.:.|..:...:....|...:::.|       ::..:|.|   ....::
Yeast  1140 YFKIKDSSIKRKYLRDNLLSYNKINEIKSSTAQYYSILKDVGFLPMDYKVGSISDLNRNERNFDI 1204

  Fly   793 RKAATAGYFY-HVARLSKGGHYKTIKHNQTVMIHPNSSLFEELPR------WVLYHELVFTSKEY 850
            .:|...|.|| |:||:    ....:|:..|     :|...|:.|.      |:       .|:||
Yeast  1205 LRAILTGAFYPHIARV----QLPDVKYLST-----SSGAVEKDPEAKMIKYWI-------RSEEY 1253

  Fly   851 MRQVIEIESKWLLEVAPHYYKAKELEDSTNKKMPKVAGRA 890
            ..::.|.::|...|.     :..:|||     :|..|.||
Yeast  1254 QDKLEEYKTKISQET-----QKVDLED-----LPLPATRA 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	209/745 (28%)
		DEXDc	269..408	CDD:238005	57/144 (40%)
		HELICc	491..581	CDD:197757	34/89 (38%)
		HA2	651..735	CDD:214852	20/90 (22%)
		OB_NTP_bind	770..869	CDD:285018	23/115 (20%)
YLR419W	NP_013523.3	UBA_YLR419W_like	369..409	CDD:270457	2/39 (5%)
		RWD	426..528	CDD:399058	16/102 (16%)
		HrpA	563..1428	CDD:224557	214/762 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810