DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and AT1G27900

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_564296.1	Gene:	AT1G27900 / 839683	AraportID:	AT1G27900	Length:	700	Species:	Arabidopsis thaliana

Alignment Length:	692	Identity:	291/692 - (42%)
Similarity:	424/692 - (61%)	Gaps:	62/692 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 SLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVA 315
            :||:..|:|.::..|:::.|::|.|||||||:||:.|.|...|:|| ..:|..||||||||:|||
plant     3 NLPILQFEEKIVETVEKNSVVVIIGETGSGKSTQLSQILHRHGYTK-SGVIAITQPRRVAAVSVA 66

  Fly   316 ARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTL 380
            .|||:|:.|.||.:|||:|||||.|:.:|.:||:|||.|.||.||.|.|..|||:|:||||||:|
plant    67 RRVAQELDVPLGEDVGYAIRFEDRTTSKTRIKYLTDGVLLRESLSNPMLDDYSVIILDEAHERSL 131

  Fly   381 HTDILFGLVKDIARFR-PELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADY 444
            :||||.||||.:.|.| ...|:||:|||||.||.|.||...|:..:||:.|||:|.|:|.....|
plant   132 NTDILLGLVKRLVRIRASNFKVLITSATLDGEKVSEFFSGCPVLNVPGKLYPVEILYSKERPVSY 196

  Fly   445 IDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIREL--------IVIPVY 501
            |::.....:.||..:|.||||:|:||||:||..       |.||..|:|.|        |:.|::
plant   197 IESSLKVAIDIHVREPEGDILIFMTGQDDIEKL-------VSRLEEKVRSLAEGSCMDAIIYPLH 254

  Fly   502 ANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVP 566
            .:||.:||.::|.|.|||.|:.|::|||||||||:|.::||||.|:.||..:|..:||.||.|:.
plant   255 GSLPPEMQVRVFSPPPPNCRRFIVSTNIAETSLTVDGVVYVIDSGYVKQRQYNPSSGMFSLDVIQ 319

  Fly   567 ISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGIN--DLI 629
            |||..|||||||||||.||||:|||....|:.:..|.|:|||||.:|..:||.||:|.:.  |::
plant   320 ISKVQANQRAGRAGRTRPGKCYRLYPLAVYRDDFLDATIPEIQRTSLAGSVLYLKSLDLPDIDIL 384

  Fly   630 HFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMV 694
            .|||||.|..|:|..||:|||.:.|::.:|.:|::||.|::.|::|.:.:.|:.:.:..|..:.:
plant   385 KFDFLDAPSSESLEDALKQLYFIDAIDENGAITRIGRTMSDLPLEPSLSRTLIEANETGCLSQAL 449

  Fly   695 TIAAMLSVNSAIF---YRPKD-KIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENF 755
            |:.||||..:.:.   .:|.: |..|.:.:.......:|||:.|||::..|..|:|...||.||.
plant   450 TVVAMLSAETTLLPARSKPSEKKRKHDEDSNLPNGSGYGDHIQLLQIFESWDRTNYDPVWCKENG 514

  Fly   756 IQYRSMKRARDVREQLVGLMQRVEIDMV---------SCLPETVNVRKAATAGYFYHVA-RLSKG 810
            :|.|.|...:|||.||..:||::..|.:         |...:...:|||...|....:| |:.:.
plant   515 MQVRGMVFVKDVRRQLCQIMQKISKDRLEVGADGRKSSSRDDYRKLRKALCVGNANQIAERMLRH 579

  Fly   811 GHYKTIK-HNQTVMIHPNSSLFEE----LPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYY 870
            ..|:|:. .:|.|.:||:|.|..:    :|.:|:||||:.|::.:||.|..::..|   |||...
plant   580 NGYRTLSFQSQLVQVHPSSVLSADNDGMMPNYVVYHELISTTRPFMRNVCAVDMAW---VAPIKR 641

  Fly   871 KAKEL----------------EDST-----NKKMPKVAGRAE 891
            |.::|                |:.|     |.:.|.|:...|
plant   642 KIEKLNVRKLSGGPAPSFKVPEEKTELSKNNAETPAVSENVE 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	281/645 (44%)
		DEXDc	269..408	CDD:238005	83/139 (60%)
		HELICc	491..581	CDD:197757	50/97 (52%)
		HA2	651..735	CDD:214852	21/87 (24%)
		OB_NTP_bind	770..869	CDD:285018	34/113 (30%)
AT1G27900	NP_564296.1	HrpA	3..639	CDD:224557	282/646 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820