DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and EMB3011

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_196805.2	Gene:	EMB3011 / 831141	AraportID:	AT5G13010	Length:	1255	Species:	Arabidopsis thaliana

Alignment Length:	918	Identity:	369/918 - (40%)
Similarity:	551/918 - (60%)	Gaps:	95/918 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DSEEESRLKDLQERDEFA---SRLKKRDDDRTRNVVDSTGGRRAIEEATKRLKL-----EHEDRD 76
            |::|.:.|.|......|.   :.|:|::.:..:.:|...|.:.::.::.|..:|     :.|||.
plant   340 DTDEGNSLFDADSASFFLGDDASLQKKETELAKRLVRRDGSKMSLAQSKKYSQLNADNAQWEDRQ 404

  Fly    77 KI----VPHLRLQSRRQYLEKRK------DDKVAELEADILDDEYLFDESVLTKREKEEREYKKQ 131
            .:    |....:|:.....|:||      |.|...|:..::                    |.||
plant   405 LLRSGAVRGTEVQTEFDSEEERKAILLVHDTKPPFLDGRVV--------------------YTKQ 449

  Fly   132 LLNIAKEHEKARELERIQRYNMPQDLKKGERSEYV-EVDEFEKQPNSEQKKWE------------ 183
            ...:....:...::..|.|        ||  |..| |:.|.:....|.|:.||
plant   450 AEPVMPVKDPTSDMAIISR--------KG--SGLVKEIREKQSANKSRQRFWELAGSNLGNILGI 504

  Fly   184 ---AEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTL 245
               |||:       .|..|...::.|:....:..|.|.:           ::.|...:.....|:
plant   505 EKSAEQI-------DADTAVVGDDGEVDFKGEAKFAQHM-----------KKGEAVSEFAMSKTM 551

  Fly   246 DETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVA 310
            .|.|:.||::..:::|:..::|:||:::.||||||||||:.|||.|.|:|.: .::|||||||||
plant   552 AEQRQYLPIFSVRDELLQVIRENQVIVVVGETGSGKTTQLTQYLHEDGYTIN-GIVGCTQPRRVA 615

  Fly   311 AMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEA 375
            |||||.||:|||..:||:::||:|||||.|...|::||||||.|.||.|.:.||..|.|:::|||
plant   616 AMSVAKRVSEEMETELGDKIGYAIRFEDVTGPNTVIKYMTDGVLLRETLKDSDLDKYRVVVMDEA 680

  Fly   376 HERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAP 440
            |||:|:||:|||::|.:...|.:.||:::||||:|:|||.||...|||.||||.:||:|.|:|.|
plant   681 HERSLNTDVLFGILKKVVARRRDFKLIVTSATLNAQKFSNFFGSVPIFNIPGRTFPVNILYSKTP 745

  Fly   441 EADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGS----KIRELIVIPVY 501
            ..||::|.....:.||.|.|.||||:|:|||||||.....|.:|:::|.|    :|..|:::|:|
plant   746 CEDYVEAAVKQAMTIHITSPPGDILIFMTGQDEIEAACFSLKERMEQLVSSSSREITNLLILPIY 810

  Fly   502 ANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVP 566
            :.||:|:|||||:.....|||.|:||||||||||:|.|.||||.|:.|...||.|.||::|.|.|
plant   811 SQLPADLQAKIFQKPEDGARKCIVATNIAETSLTVDGIYYVIDTGYGKMKVFNPRMGMDALQVFP 875

  Fly   567 ISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHF 631
            ||:|:::|||||||||.||.|:||||..||.:|:..:.||||||.||||.||:||:|.|::|:.|
plant   876 ISRAASDQRAGRAGRTGPGTCYRLYTESAYLNEMLPSPVPEIQRTNLGNVVLLLKSLKIDNLLDF 940

  Fly   632 DFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTI 696
            ||:||||.|.::.::.||:.|||||:.|.||.||.:|.|||:||.:.||||..|:..|.:|::||
plant   941 DFMDPPPQENILNSMYQLWVLGALNNVGGLTDLGWKMVEFPLDPPLAKMLLMGERLDCIDEVLTI 1005

  Fly   697 AAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSM 761
            .:||||.| :|:|||::...:|.||:.|.....|||:||.||.||.|.||...||.::::|.:.:
plant  1006 VSMLSVPS-VFFRPKERAEESDAAREKFFVPESDHLTLLNVYQQWKEHDYRGDWCNDHYLQVKGL 1069

  Fly   762 KRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHP 826
            ::||:||.||:.::::::|::.||.|:...||||..:.||::.|||...|.|...:......:||
plant  1070 RKAREVRSQLLDILKQLKIELRSCGPDWDIVRKAICSAYFHNSARLKGVGEYVNCRTGMPCHLHP 1134

  Fly   827 NSSLF--EELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKE-----LEDSTNKKMP 884
            :|:|:  ...|.:|:||||:.|:||||:....:|..||.|:.|.::..|:     ||....:|..
plant  1135 SSALYGLGYTPDYVVYHELILTTKEYMQCATSVEPHWLAELGPMFFSVKDSDTSMLEHKKKQKEE 1199

  Fly   885 KVAGRAEM 892
            |.....||
plant  1200 KSGMEEEM 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	316/650 (49%)
		DEXDc	269..408	CDD:238005	80/138 (58%)
		HELICc	491..581	CDD:197757	51/89 (57%)
		HA2	651..735	CDD:214852	41/83 (49%)
		OB_NTP_bind	770..869	CDD:285018	37/100 (37%)
EMB3011	NP_196805.2	DUF1777	158..>247	CDD:285811
		DEXDc	553..739	CDD:214692	103/186 (55%)
		DEXDc	575..713	CDD:238005	80/138 (58%)
		HELICc	806..892	CDD:197757	51/85 (60%)
		HA2	961..1043	CDD:214852	41/82 (50%)
		OB_NTP_bind	1077..1177	CDD:285018	36/99 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720