DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and DHX40

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_078888.4	Gene:	DHX40 / 79665	HGNCID:	18018	Length:	779	Species:	Homo sapiens

Alignment Length:	711	Identity:	288/711 - (40%)
Similarity:	423/711 - (59%)	Gaps:	55/711 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 EKSSSRQPE------LTEKERKRLTLDE--TRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKT 282
            |:|...|.|      :.::|.|..|..|  |..:.|:...::.:|.||:::..||:.|.||||||
Human    19 ERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKT 83

  Fly   283 TQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILK 347
            ||:|:||.||||:: ..|||.||||:|||:|||.||||||...||::|||.:||:||:|..|.:|
Human    84 TQLPKYLYEAGFSQ-HGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIK 147

  Fly   348 YMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDI-----ARFRPELKLLISSAT 407
            |||||.|.:..|.:|:|..:||:|:||||||||.|||||||:|.:     ...:..||:::.|||
Human   148 YMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSAT 212

  Fly   408 LDAEKFSAFFDDAPIFRIPGRRYPV-DIFYTKAPEAD-----YIDACCVSVLQIHATQPLGDILV 466
            ::..|.||||.:.|||.||||.||| :.|.......|     ||.|.....:.||..:..|||||
Human   213 MELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILV 277

  Fly   467 FLTGQDEIETCQEVLHDRVKRL-------GSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVI 524
            |||||.|||...|:|....:.:       .:.:..|:::|.|.::.:|.|.:||.|.||..||.:
Human   278 FLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCV 342

  Fly   525 LATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFR 589
            ::|||:.||||||.|.||:|.||.||.|.|.|.|::.|.||||||:.|.||:||||||:.|||||
Human   343 ISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFR 407

  Fly   590 LYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGA 654
            :|:...:...:.|:.:|||:|.:|.:.||.||.|.|:|:|.|.:||||....::.||:|||...|
Human   408 IYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDA 472

  Fly   655 LNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKD------- 712
            ::..|.:|:||..|.|||:.|.:...::.:....|.:.::.|||||||.: :|.||.|
Human   473 IDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVEN-VFIRPVDPEYQKEA 536

  Fly   713 KIIHADTARK--NFNHMHGDHLSLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLM 775
            :..|.:.|.|  .||    |..:|..::.|...:.....||.:::|.:|.:..|..|..||..|:
Human   537 EQRHRELAAKAGGFN----DFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELI 597

  Fly   776 QRVEIDMVSCLP-ETVN------VRKAATAGYFYHVARLSKGGHYKTIK-HNQTVMIHPNSSLFE 832
            ::::  ..|..| ||..      :|:...||||.:|||.|.|..:.|:. ....|.|||:|:|.|
Human   598 RKLK--QQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHE 660

  Fly   833 ELPR--WVLYHELVFTSKEYMRQVIEIESKWLLEVAP--HYYKAKELEDSTNKKMPKVAGR 889
            :..:  |:::||::.|:|.|.|.|..|..:|:.::.|  |.:.|.:|.....:::.:.|.|
Human   661 QETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARR 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	282/685 (41%)
		DEXDc	269..408	CDD:238005	81/143 (57%)
		HELICc	491..581	CDD:197757	46/89 (52%)
		HA2	651..735	CDD:214852	28/92 (30%)
		OB_NTP_bind	770..869	CDD:285018	36/110 (33%)
DHX40	NP_078888.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		3/8 (38%)
		HrpA	16..770	CDD:224557	288/711 (41%)
		DEAH box	173..176		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..779
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820