DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and dhx33

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001093527.3	Gene:	dhx33 / 796505	ZFINID:	ZDB-GENE-131127-77	Length:	680	Species:	Danio rerio

Alignment Length:	640	Identity:	292/640 - (45%)
Similarity:	414/640 - (64%)	Gaps:	16/640 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRV 309
            ::..||.||:|..:..:|:.:::....:..||||||||||:||||.|||..: :.:|..||||||
Zfish    40 VEAQRRHLPIYQSRTQVISQLRQLHSAVFIGETGSGKTTQIPQYLYEAGIGR-QGIIAITQPRRV 103

  Fly   310 AAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDE 374
            ||:|:|.|||||..|:||..|||::||||.||..|.||:||||.|.||.:.:|.|..|:|:|:||
Zfish   104 AAISLAGRVAEEKKVQLGKLVGYTVRFEDVTSPETKLKFMTDGMLLREAIGDPLLLRYTVVILDE 168

  Fly   375 AHERTLHTDILFGLVKDIARFRPE-----LKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDI 434
            |||||:|||:|||:||...|.|.|     ||:::.|||:|.:.||.:|:.:|:..:.||::|:.|
Zfish   169 AHERTVHTDVLFGVVKAAQRRRLEQNKIPLKVVVMSATMDVDLFSQYFNKSPVLYLEGRQHPIQI 233

  Fly   435 FYTKAPEADYIDACCVSVLQIHATQPLG-DILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVI 498
            :|||.|::||:.|..||:.|||...|.. |||||||||:|||.......|..|.|......:.|:
Zfish   234 YYTKQPQSDYLQAALVSIFQIHQEAPSSHDILVFLTGQEEIEALARTCRDISKHLPDTSGSMTVV 298

  Fly   499 PVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLM 563
            |:||:||...|.::|.|.|..:|||||:|||||||:||..|.||||.|..|...||..:|:|.|.
Zfish   299 PLYASLPPAQQMRVFLPAPKGSRKVILSTNIAETSITISGIKYVIDTGMVKAKRFNPDSGLEVLA 363

  Fly   564 VVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDL 628
            |..:|||.|.||||||||...|.|:||||...::: |.:.|||||||.||.:.||.|.|||:.|:
Zfish   364 VQRVSKAQAWQRAGRAGREDAGSCYRLYTEDEFEN-LANMTVPEIQRCNLASVVLQLLALGVPDV 427

  Fly   629 IHFDFLDPPPHETLVLALEQLYALGALNH---HGELTKLGRRMAEFPVDPMMGKMLLASEKYKCS 690
            ::|||:..|..|::..|:|||..|||::.   |..||.||::||.||::|...|.||.|..:.|:
Zfish   428 LNFDFVSKPSPESMRTAVEQLCILGAVDRKDDHVSLTPLGKKMACFPLEPRFSKTLLISPDFSCT 492

  Fly   691 EEMVTIAAMLSVNSAIFYRP--KDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYE 753
            ||::||.::|||:|.::..|  :|::|   :.||.|....|||::||.:|..:.:...:..||.|
Zfish   493 EEILTIISLLSVDSVLYNPPARRDEVI---SVRKKFISSEGDHITLLNIYRAFKKVSGNKDWCRE 554

  Fly   754 NFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKH 818
            ||:..|:|....:||.||..:..::.:.:.|.:.:..|||:....|.|...|.|...|.|..:..
Zfish   555 NFVNSRNMGLVGEVRAQLRDICIKMNLKLESSVCDLANVRRCLAHGLFMSAAELQPDGSYVALDT 619

  Fly   819 NQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAK 873
            :|.|.|||:|.||:..|..||::||:.||:.|||.:..|::.||.|.||.|::.|
Zfish   620 HQPVSIHPSSVLFQARPVCVLFNELLHTSRCYMRDLCLIQTDWLHEAAPEYFRRK 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	288/632 (46%)
		DEXDc	269..408	CDD:238005	82/143 (57%)
		HELICc	491..581	CDD:197757	47/89 (53%)
		HA2	651..735	CDD:214852	35/88 (40%)
		OB_NTP_bind	770..869	CDD:285018	36/98 (37%)
dhx33	NP_001093527.3	DEXDc	50..234	CDD:214692	93/184 (51%)
		DEXDc	64..207	CDD:238005	82/143 (57%)
		Helicase_C	264..381	CDD:278689	61/116 (53%)
		HA2	451..536	CDD:214852	35/87 (40%)
		OB_NTP_bind	570..670	CDD:285018	36/99 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730