DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and Tdrd9

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_083332.1	Gene:	Tdrd9 / 74691	MGIID:	1921941	Length:	1383	Species:	Mus musculus

Alignment Length:	704	Identity:	199/704 - (28%)
Similarity:	327/704 - (46%)	Gaps:	120/704 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 EVDEFEKQPNSE---QKKWEAEQLASAR------FHFGAKDAKAE--EEYELLLDDQIDFI---Q 217
            ||...|:.||.:   |.:...:..|.||      .....:.::.|  .:|..|.:.::|..   |
Mouse    40 EVQRSEEVPNEDPTAQAQVPVKATAPARPASTSGRSLSQRSSEMEYINKYRQLEEQELDIYGQDQ 104

  Fly   218 ALTLDGSREKSSSRQ-----PELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGET 277
            ..:..|.|...:...     ||.|.|          ...||:...||::|:.::.:.|:||.|.|
Mouse   105 PPSGPGLRSPLAKLSNVACIPETTYK----------YPDLPINRCKEEVISLIESNSVVIIHGAT 159

  Fly   278 GSGKTTQVPQYLVEAGFTKDKKM--IGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCT 340
            ||||:||:|||::: .:|:....  |..||||::.|.|:|..:::|....||..|||.:..|...
Mouse   160 GSGKSTQLPQYVLD-HYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKIA 223

  Fly   341 SDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPE-LKLLIS 404
            ::.|.|.|||.|.|.::.:|...|..::.:.|||.||||...|.|..:|:.:.|.... :|:::.
Mouse   224 TEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLM 288

  Fly   405 SATLDAEKFSAFF--------DDAPIFRIPGRRYPVDIFYTKAPEADY----------------I 445
            |||::.::|:.:|        :.|.:|.:.|:.:.::.:|.......|                :
Mouse   289 SATINCKQFADYFAVPVQNKMNPAYVFEVEGKPHAIEEYYLNDLGHIYHSGLPYRLEEPVITKDV 353

  Fly   446 DACCVSVLQI-----------------HATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIR 493
            ....||::|:                 ........:||||.|..||....|:|.:.:.      :
Mouse   354 YEVAVSLIQMFDDLDMKESGNKTWSGAQFVSERSSVLVFLPGLGEINYMHELLTNMIH------K 412

  Fly   494 ELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTG 558
            .|.|.|:::::..:.|..:|....|..||:||:|||||:|:|:.::.||||....:....:..|.
Mouse   413 RLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTN 477

  Fly   559 MESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKAL 623
            .:||.:...||.|.:||.|||||.:.|.|:||.....:...:.|:.|||:.|..||:.:|.:|.|
Mouse   478 YQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAIPDHVVPEMLRCPLGSTILKVKLL 542

  Fly   624 GIND--LIHFDFLDPP---PHETLVLALEQLYALGALN-------HHGELTKLGRRMAEFPVDPM 676
            .:.:  .:....|.||   ..|..:|.|:::.||....       |.||||.|||.:|:.||...
Mouse   543 DMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQ 607

  Fly   677 MGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHG----DHLSLLQV 737
            :||:::....:.|.:|.:.|||.||:.: .|..|..:  |.|..| |..|..|    |.|:|::.
Mouse   608 LGKLVVLGHVFGCLDECLIIAAALSLKN-FFTMPFRQ--HLDGYR-NKVHFSGSSRSDCLALVEA 668

  Fly   738 YNQWA-------------ETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRV 778
            :..|.             |.|    |...|:||   :||.|:|.|....|..|:
Mouse   669 FRAWQACRQRGELRRPKDELD----WGRLNYIQ---IKRIREVAELYEELKNRI 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	185/635 (29%)
		DEXDc	269..408	CDD:238005	53/141 (38%)
		HELICc	491..581	CDD:197757	32/89 (36%)
		HA2	651..735	CDD:214852	32/94 (34%)
		OB_NTP_bind	770..869	CDD:285018	2/9 (22%)
Tdrd9	NP_083332.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..82		9/41 (22%)
		HrpA	111..>717	CDD:224557	184/633 (29%)
		DEXDc	151..292	CDD:238005	53/141 (38%)
		DEAH box. /evidence=ECO:0000269\|PubMed:28633017	256..259		2/2 (100%)
		Helicase_C	384..501	CDD:278689	42/122 (34%)
		HA2	589..666	CDD:214852	29/80 (36%)
		TUDOR	905..1014	CDD:278965
		TUDOR	950..997	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810