DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and Dhx34

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001272860.1	Gene:	Dhx34 / 71723	MGIID:	1918973	Length:	1145	Species:	Mus musculus

Alignment Length:	738	Identity:	241/738 - (32%)
Similarity:	373/738 - (50%)	Gaps:	88/738 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 HEDRDKIVPHLRLQSRRQYLEKRKDDKVAELEADILDDEYLFDESVLTKREKEEREYKKQLLNIA 136
            |.|||    |.| ..|.:...::.|....|... :|:|.:..||..:.:..:|.:::
Mouse    12 HRDRD----HHR-APREEEAPEKWDWNCPETRC-LLEDVFFRDEDYIRRGSEECQKF-------- 62

  Fly   137 KEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQKKWEAEQLASARFHFGAKDAKA 201
                 ....||:||:   |.||..::.        ||.|.  ..|.....||.....:
Mouse    63 -----WAFFERLQRF---QHLKTSQKK--------EKDPG--MPKHGIAALADLPLTY------- 102

  Fly   202 EEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRL----------------TLDETRR 250
            :..|.:.|.     |.:....|.........||...:.|:.|                .|...|.
Mouse   103 DPRYRINLS-----ILSPDTRGRHGPGRGLPPERVSEFRRALLHYLDFQQKQAFGRLVKLQRERA 162

  Fly   251 SLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVA 315
            :||:..:...::..:|||||:::.|:||.||:|||||||:.|||:.    :.||||||:|.:|:|
Mouse   163 ALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSH----VACTQPRRIACISLA 223

  Fly   316 ARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTL 380
            .||..|...:.|::|||.||||...|..|.:.::|.|.|.|:...||.|..|.|:|:||.|||.|
Mouse   224 KRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYQVLIVDEVHERHL 288

  Fly   381 HTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYI 445
            |.|.|.|:::.:...||:||:::.|||::...||::|..||:.::|||.:|:.:.| :..|||..
Mouse   289 HNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSHAPVVQVPGRLFPITVVY-QPQEADQT 352

  Fly   446 DACC--------VSVLQI----HATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVI 498
            .:..        :.||:.    :..:..||:||||:|..||.|   || |..:...|..:..:|:
Mouse   353 ASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMAEITT---VL-DAAQAYASLTQRWVVL 413

  Fly   499 PVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLM 563
            |:::.|....|.|:|:..|...||.||:|||||||:|||.|.:|:|.|..|:.:::.:..::.|.
Mouse   414 PLHSALSVSDQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQ 478

  Fly   564 VVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDL 628
            ...||:|||.||.||||||.||.|:|||....| .......||||:|:.|...||.:|::.:.|.
Mouse   479 EFWISQASAEQRKGRAGRTGPGVCYRLYAESDY-DAFAPYPVPEIRRVALDALVLQMKSMSVGDP 542

  Fly   629 IHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEM 693
            ..|.|::|||..::..|:..|...|||:....||.:|..:|:.|||.::||||:....:..:|.:
Mouse   543 RTFPFIEPPPPASVETAILYLQEQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLAEPV 607

  Fly   694 VTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAE-----TDYSTQWCYE 753
            :||||.|||.|. |.|.....:...|||:......||..:|..|:|.|.:     :..|.:||..
Mouse   608 LTIAAALSVQSP-FTRSAQSNLDCATARRPLESDQGDPFTLFNVFNAWVQVKSERSGNSRKWCRR 671

  Fly   754 NFIQYRSMKRARDVREQLVGLMQ 776
            ..::...:....::|.|...|::
Mouse   672 RGVEEHRLYEMANLRRQFKELLE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	211/588 (36%)
		DEXDc	269..408	CDD:238005	65/138 (47%)
		HELICc	491..581	CDD:197757	37/89 (42%)
		HA2	651..735	CDD:214852	30/83 (36%)
		OB_NTP_bind	770..869	CDD:285018	2/7 (29%)
Dhx34	NP_001272860.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		7/19 (37%)
		HrpA	153..>688	CDD:224557	204/545 (37%)
		DEAH box	281..284		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..764
		OB_NTP_bind	800..910	CDD:369483
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1091..1114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810