Protein Alignment l(2)37Cb and Dhx34

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_082159.3
• Gene: Dhx34 / 71723
• MGIID: 1918973
• Length: 1145
• Species: Mus musculus
• Alignment Length: 738
• Identity: 241/738 - (32%)
• Similarity: 373/738 - (50%)
• Gaps: 88/738 - (11%)

  Fly    72 HEDRDKIVPHLRLQSRRQYLEKRKDDKVAELEADILDDEYLFDESVLTKREKEEREYKKQLLNIA 136
            |.|||    |.| ..|.:...::.|....|... :|:|.:..||..:.:..:|.:::
Mouse    12 HRDRD----HHR-APREEEAPEKWDWNCPETRC-LLEDVFFRDEDYIRRGSEECQKF-------- 62

  Fly   137 KEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQKKWEAEQLASARFHFGAKDAKA 201
                 ....||:||:   |.||..::.        ||.|.  ..|.....||.....:
Mouse    63 -----WAFFERLQRF---QHLKTSQKK--------EKDPG--MPKHGIAALADLPLTY------- 102

  Fly   202 EEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRL----------------TLDETRR 250
            :..|.:.|.     |.:....|.........||...:.|:.|                .|...|.
Mouse   103 DPRYRINLS-----ILSPDTRGRHGPGRGLPPERVSEFRRALLHYLDFQQKQAFGRLVKLQRERA 162

  Fly   251 SLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVA 315
            :||:..:...::..:|||||:::.|:||.||:|||||||:.|||:.    :.||||||:|.:|:|
Mouse   163 ALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSH----VACTQPRRIACISLA 223

  Fly   316 ARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTL 380
            .||..|...:.|::|||.||||...|..|.:.::|.|.|.|:...||.|..|.|:|:||.|||.|
Mouse   224 KRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYQVLIVDEVHERHL 288

  Fly   381 HTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPEADYI 445
            |.|.|.|:::.:...||:||:::.|||::...||::|..||:.::|||.:|:.:.| :..|||..
Mouse   289 HNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSHAPVVQVPGRLFPITVVY-QPQEADQT 352

  Fly   446 DACC--------VSVLQI----HATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVI 498
            .:..        :.||:.    :..:..||:||||:|..||.|   || |..:...|..:..:|:
Mouse   353 ASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMAEITT---VL-DAAQAYASLTQRWVVL 413

  Fly   499 PVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLM 563
            |:::.|....|.|:|:..|...||.||:|||||||:|||.|.:|:|.|..|:.:::.:..::.|.
Mouse   414 PLHSALSVSDQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQ 478

  Fly   564 VVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDL 628
            ...||:|||.||.||||||.||.|:|||....| .......||||:|:.|...||.:|::.:.|.
Mouse   479 EFWISQASAEQRKGRAGRTGPGVCYRLYAESDY-DAFAPYPVPEIRRVALDALVLQMKSMSVGDP 542

  Fly   629 IHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEM 693
            ..|.|::|||..::..|:..|...|||:....||.:|..:|:.|||.::||||:....:..:|.:
Mouse   543 RTFPFIEPPPPASVETAILYLQEQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLAEPV 607

  Fly   694 VTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAE-----TDYSTQWCYE 753
            :||||.|||.|. |.|.....:...|||:......||..:|..|:|.|.:     :..|.:||..
Mouse   608 LTIAAALSVQSP-FTRSAQSNLDCATARRPLESDQGDPFTLFNVFNAWVQVKSERSGNSRKWCRR 671

  Fly   754 NFIQYRSMKRARDVREQLVGLMQ 776
            ..::...:....::|.|...|::
Mouse   672 RGVEEHRLYEMANLRRQFKELLE 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	39/210 (19%)
		HrpA	251..>868	CDD:441249	204/543 (38%)
Dhx34	NP_082159.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		7/19 (37%)
		HrpA	162..>628	CDD:441249	189/476 (40%)
		DEAH box	281..284		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	726..764
		OB_NTP_bind	800..911	CDD:400182
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1091..1114