Protein Alignment l(2)37Cb and DHX37

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_005253647.1
• Gene: DHX37 / 57647
• HGNCID: 17210
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 1055
• Identity: 311/1055 - (29%)
• Similarity: 466/1055 - (44%)
• Gaps: 293/1055 - (27%)

  Fly    68 LKLEHEDRDK----------IVPHLRLQSRRQYLEKRKDDKVAELEADILDDEYLFDESVLTKRE 122
            ::||.||:|.          ::|.          :|:|..|...|...        ::..|||:|
Human    30 VQLELEDKDTLKGVDASNALVLPG----------KKKKKTKAPPLSKK--------EKKPLTKKE 76

  Fly   123 KEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSE------YV--------------- 166
                  ||.|..|.::.||     :.||..|.|.|.:.:.||      |.
Human    77 ------KKVLQKILEQKEK-----KSQRAEMLQKLSEVQASEAEMRLFYTTSKLGTGNRMYHTKE 130

  Fly   167 EVDEF------------------EKQPNSEQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQI 213
            :.||.                  .:.|::|:::.|.|:          .:::.|||.||..|...
Human   131 KADEVVAPGQEKISSLSGAHRKRRRWPSAEEEEEEEEE----------SESELEEESELDEDPAA 185

  Fly   214 DFIQA------LTLDGSREKSS--------------------------------SRQPELTEKER 240
            :..:|      ..|..:...||                                :|.||:.|:
Human   186 EPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPLPRALAKPAVFIPVNRSPEMQEE-- 248

  Fly   241 KRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQ 305
                    |..||:...::.::.||.||.::|:.|||||||||||||:|.||||:.:..:||.|:
Human   249 --------RLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVTE 305

  Fly   306 PRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVM 370
            ||||||::::.|||:||.:. ...|.|.||:|...::.|.:|:||||.|.:|...:..|..|.|:
Human   306 PRRVAAVAMSQRVAKEMNLS-QRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVV 369

  Fly   371 IIDEAHERTLHTDILFGLVKDIARFRPE----LKLLISSATLDAEKFS----AFFDDAPIFRIPG 427
            ||||||||:::||||.||:..|...|.:    |||||.||||..|.|:    .|....|:.::..
Human   370 IIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVES 434

  Fly   428 RRYPVDIFYTK-APEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIET-CQEV---------- 480
            |::||.:.:.| .|..||...|...|.:||...|.|.||||||||.|:.. |:.:
Human   435 RQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRAR 499

  Fly   481 -------LHDRVKRL---------------------------------GSKIRE----------- 494
                   ..|.|:.:                                 |.:.||
Human   500 PQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALD 564

  Fly   495 -----------------------LIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTI 536
                                   |.|:|:|:.|..:.||::|:|.|...|..::|||:|||||||
Human   565 SDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTI 629

  Fly   537 DNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELE 601
            ..|.||:|.|..|:..::..||:.|..|..:|:|||:|||||||||.||.|:|||:: |...:.|
Human   630 PGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSS-AVFGDFE 693

  Fly   602 DNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGE------ 660
            ....|||.|..:.:.:|.:|||.:..:|:|.|..||..|.|:.|.|.|.|||||....:
Human   694 QFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPPQKAERVKQ 758

  Fly   661 ---------LTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIH 716
                     :|.|||.||.|||.|...|||..|.::.|....:||.|.::|..  .:...|:...
Human   759 LQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRE--LFEELDRPAA 821

  Fly   717 ADTARKNFNHMHGDHLSLLQVYNQWA-------------------ETDYST---QWCYENFIQYR 759
            :|   :....:......:.|:...||                   ..:|::   |:|..|.::|:
Human   822 SD---EELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGLRYK 883

  Fly   760 SMKRARDVREQLVGLMQRV--EIDMV---SCLPETVN----VRKAATAGYFYHVARLSKG----- 810
            :|...|.:|.||...:..|  |.::.   ...|.|.:    :|:..|||...|:||..:.
Human   884 AMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLE 948

  Fly   811 ----GHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYK 871
                ..|||...:..|.|||:|.||:|||.:|:|.|:|.|:|.||:.|..:|.:|:..:.|.|.:
Human   949 DKWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQ 1013

  Fly   872 -AKELEDSTNKKMPK 885
             .|.||:......|:
Human  1014 FDKPLEEPAPTYCPE 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	53/285 (19%)
		HrpA	251..>868	CDD:441249	256/765 (33%)
DHX37	XP_005253647.1	HrpA	252..>1043	CDD:441249	262/784 (33%)