DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and dhx40

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_021322026.1	Gene:	dhx40 / 570225	ZFINID:	ZDB-GENE-080507-1	Length:	734	Species:	Danio rerio

Alignment Length:	689	Identity:	290/689 - (42%)
Similarity:	431/689 - (62%)	Gaps:	44/689 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 LTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKK 299
            ::.|:|...|.....:.||:|.:|:.|:.||:|:..||:.||||||||||:||||.:||.:::.:
Zfish     1 MSTKKRSSETEHHESKKLPIYQYKDKLVQAVEENTFLIVTGETGSGKTTQLPQYLYKAGLSRNGR 65

  Fly   300 MIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDL 364
             ||.||||||||::||.||:.||.|:||.||||.:||:||::..|::||||||.|.||.|::|.|
Zfish    66 -IGVTQPRRVAAITVAQRVSSEMQVRLGEEVGYQVRFDDCSTKDTMIKYMTDGCLLREILADPSL 129

  Fly   365 ASYSVMIIDEAHERTLHTDILFGLVKDI-----ARFRPELKLLISSATLDAEKFSAFFDDAPIFR 424
            ..||::|:||||||:|:||:|.||:|..     ...:..||:::.||||:.||.|:|:.:.|:|.
Zfish   130 TQYSIVILDEAHERSLNTDVLLGLLKKTLLKGSRGNKTPLKVVVMSATLETEKLSSFYGNCPVFT 194

  Fly   425 IPGRRYPV-----DIFYTKAPEAD-YIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHD 483
            ||||.|||     ::...|..|:. |:.......|.:|..:..||||||||||.|||...::|.:
Zfish   195 IPGRTYPVKETFCNLIGPKDKESSVYVKEVVKMTLDVHTNEAAGDILVFLTGQSEIEKACDLLFE 259

  Fly   484 RVKRLGSK-------IRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIY 541
            :.:.|..:       :..|:::.:|.::|:|.|.:||:|.|...||.::|||||.||||||.|.|
Zfish   260 KAEILDYRYDVHDRSVDGLLILSLYGSMPTDQQRQIFQPAPKGVRKCVVATNIAATSLTIDGIRY 324

  Fly   542 VIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVP 606
            ::|.||.||.|.|||.|::.|.||||||:.|.||||||||||.|||||:|:...:...:.:.|:|
Zfish   325 IVDSGFVKQLNHNSRVGLDILEVVPISKSEAQQRAGRAGRTAAGKCFRIYSKDFWDTCMPEYTIP 389

  Fly   607 EIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEF 671
            ||||.:|.:.:|.||.||::|:|.|.:||.|....::.||:|||...|::..||:|||||.|.||
Zfish   390 EIQRTSLTSVILTLKCLGVHDVIRFPYLDCPEERFILTALKQLYQYDAIDRRGEVTKLGRLMVEF 454

  Fly   672 PVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRP--KDKIIHADTARKNFNHMHG---DH 731
            |:.|.:.:.||.:....|.:.|:.:||||||.: ||.||  .:|...|:...|......|   |.
Zfish   455 PLPPNLTRALLKAAALGCEDIMLPVAAMLSVEN-IFIRPGKPEKQKEAEVRHKEIAACSGGSNDF 518

  Fly   732 LSLLQVYNQWAETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLP-------ET 789
            |.||.|:.:...::..:.||.||:|.:|::|.|..|..||..::.|::  .....|       .:
Zfish   519 LMLLCVFEKCRASENPSAWCKENWIHWRAVKSAFSVETQLREILLRLK--QQKDFPHERFEGSRS 581

  Fly   790 VNVRKAATAGYFYHVARLSKGGHYKTIK-HNQTVMIHPNSSLF-EELP-RWVLYHELVFTSKEYM 851
            ..:|:....|||.:|||.|.|..:.|:. |..:|:|||:|.|| :||. .|:::|:::.||:.|:
Zfish   582 ELLRQCLCLGYFTNVARRSIGKSFCTMDGHGSSVLIHPSSCLFGQELQLDWIIFHDVLVTSRVYV 646

  Fly   852 RQVIEIESKWLLEVAP--HYYKAKEL-----EDSTNKKM 883
            |.|..|...|:.::.|  |.....||     |:.|:::|
Zfish   647 RTVCPIRYDWVKDLLPKLHEIDVYELSSVAREEVTDEEM 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	283/664 (43%)
		DEXDc	269..408	CDD:238005	78/143 (55%)
		HELICc	491..581	CDD:197757	48/96 (50%)
		HA2	651..735	CDD:214852	33/88 (38%)
		OB_NTP_bind	770..869	CDD:285018	34/110 (31%)
dhx40	XP_021322026.1	HrpA	15..696	CDD:224557	287/675 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820