DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and DHX32

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_060650.2	Gene:	DHX32 / 55760	HGNCID:	16717	Length:	743	Species:	Homo sapiens

Alignment Length:	733	Identity:	232/733 - (31%)
Similarity:	396/733 - (54%)	Gaps:	64/733 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 VEVDEFEKQPNSEQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSSS 230
            :|.:..|...:|.:|::..|.|.|         :..:||..|..:|    ::....||.  ..||
Human     1 MEEEGLECPNSSSEKRYFPESLDS---------SDGDEEEVLACED----LELNPFDGL--PYSS 50

  Fly   231 RQPELTEKERKRLTLDETRRSLPV----YPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVE 291
            |..:|.::          |..||:    |.|.|:|:    ::|::|:.|:...||:.||||:..|
Human    51 RYYKLLKE----------REDLPIWKEKYSFMENLL----QNQIVIVSGDAKCGKSAQVPQWCAE 101

  Fly   292 AGFTKDKKMIG--CTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTL 354
            ...:...:..|  |||..:...:.:|.|||:||.|.:|:||||.|.||:|.::.|||:|.||..|
Human   102 YCLSIHYQHGGVICTQVHKQTVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDML 166

  Fly   355 HREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDD 419
            .||.:|.|.|.||.|:|:|:.|||::.||:|.||:||:...||||||:|:|:.....|.::::.:
Human   167 QREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGN 231

  Fly   420 APIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIE-TCQEVLHD 483
            .|:..:. .::||::.|....:.|..::....:.:||.:...|||:|||..:.:|| .|:.|...
Human   232 VPVIEVK-NKHPVEVVYLSEAQKDSFESILRLIFEIHHSGEKGDIVVFLACEQDIEKVCETVYQG 295

  Fly   484 RVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPN-------ARKVILATNIAETSLTIDNIIY 541
              ..|...:.||:|:|:|   |.: :..:|:|....       .|:|:|.|:..|..:..:::.:
Human   296 --SNLNPDLGELVVVPLY---PKE-KCSLFKPLDETEKRCQVYQRRVVLTTSSGEFLIWSNSVRF 354

  Fly   542 VIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVP 606
            |||.|..::..:|.|....||::.|||::.|..|....|.::.||.|.|||......::......
Human   355 VIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKDMTPLKPA 419

  Fly   607 EIQRINLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEF 671
            |:|..||.:.||.:|.:.|..|.|.||::.|..|:|:.|||.|..|.||::.|.|::.|..|:||
Human   420 EMQEANLTSMVLFMKRIDIAGLGHCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEF 484

  Fly   672 PVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQ 736
            |:||.:.|.:|||.::.|.:|::|||||::..:...:.|......|.|..|.|.|..|||.:|:.
Human   485 PLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHVPHGAEEAALTCWKTFLHPEGDHFTLIS 549

  Fly   737 VYNQWAETDYST-------QWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMV----SCLPETV 790
            :|..:.:|..::       :||.:.|:...:::.|..:|.:|:.:::|:|:...    .....|:
Human   550 IYKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMADVIRAELLEIIKRIELPYAEPAFGSKENTL 614

  Fly   791 NVRKAATAGYFYHVAR-LSKGGHYKTIKHNQTVMIHPNS--SLFEELPRWVLYHELVFTSKEYMR 852
            |::||..:|||..:|| :...|:|..:.|.|...:||.|  |:.:::|.|||:|:...:...|:|
Human   615 NIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGYSITKKMPEWVLFHKFSISENNYIR 679

  Fly   853 QVIEIESKWLLEVAPHYY 870
            ...||..:..:::.|.||
Human   680 ITSEISPELFMQLVPQYY 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	218/672 (32%)
		DEXDc	269..408	CDD:238005	65/140 (46%)
		HELICc	491..581	CDD:197757	26/96 (27%)
		HA2	651..735	CDD:214852	32/83 (39%)
		OB_NTP_bind	770..869	CDD:285018	30/105 (29%)
DHX32	NP_060650.2	Preny group binding site; CAAX box	1..743		232/733 (32%)
		HrpA	12..679	CDD:224557	224/702 (32%)
		DEAD/DEXH domain	146..403		88/263 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820