Protein Alignment l(2)37Cb and DHX29

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_061903.2
• Gene: DHX29 / 54505
• HGNCID: 15815
• Length: 1369
• Species: Homo sapiens
• Alignment Length: 1071
• Identity: 283/1071 - (26%)
• Similarity: 485/1071 - (45%)
• Gaps: 230/1071 - (21%)

  Fly     4 KNRKRTASSSSSGEEP---DSEEESRLKDLQERDEFASRLKKRDDDRTRN---VVDSTGGRR--- 59
            :|.::....::.||..   :..|:|.....:|:|      ||::....||   ...|..|:.
Human   323 QNERKKPPVATEGESALNFNLFEKSAAATEEEKD------KKKEPHDVRNFDYTARSWTGKSPKQ 381

  Fly    60 -AIEEATKRLKLEHEDRDKIVPHLRLQSRRQYLEKRKDDKVAE----LEADILDDEYLFDESVLT 119
             .|:...|.|........:.||..|....|..:.|.:||.:..    |..|.:..::|.....|.
Human   382 FLIDWVRKNLPKSPNPSFEKVPVGRYWKCRVRVIKSEDDVLVVCPTILTEDGMQAQHLGATLALY 446

  Fly   120 KREKEER-------EYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNS 177
            :..|.:.       .|:...|..:...:|..||.:::. |.|:||...:....::..:.::|.:|
Human   447 RLVKGQSVHQLLPPTYRDVWLEWSDAEKKREELNKMET-NKPRDLFIAKLLNKLKQQQQQQQQHS 510

  Fly   178 EQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSR------EKSSSRQPELT 236
            |.|:..:|.              .||.:|.|:.|: || .||:|:.:.      .::..|:.:.|
Human   511 ENKRENSED--------------PEESWENLVSDE-DF-SALSLESANVEDLEPVRNLFRKLQST 559

  Fly   237 EKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVE----AGFTKD 297
            .|.:|.|   :.|:.|||:..::.::..:|.|:|:::.|||||||:||||.:|:|    ..:...
Human   560 PKYQKLL---KERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEAS 621

  Fly   298 KKMIGCTQPRRVAAMSVAARVAEEMGVKLG----NEV-GYSIRFEDCTSDRTILKYMTDGTLHRE 357
            |..|.||||||::|:|:|.||.:|:|.:.|    |.: ||.||.|....:.|.|.|.|.|.|.|:
Human   622 KCNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRK 686

  Fly   358 FLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPI 422
            ...:..|::.|.:|:||.|||::.:|.|..::|:|.:.|.:|.|::.|||:|:||||.:|...||
Human   687 LQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFTHCPI 751

  Fly   423 FRIPGRRYPVDIFYTK----------APEADYIDACCVSVLQ------IHATQPLGDI------- 464
            .||.||.|||::|:.:          ..:::|    |...|:      |:.|...|.|
Human   752 LRISGRSYPVEVFHLEDIIEETGFVLEKDSEY----CQKFLEEEEEVTINVTSKAGGIKKYQEYI 812

  Fly   465 ----------------------------------------------------------LVFLTGQ 471
                                                                      |:||.|.
Human   813 PVQTGAHADLNPFYQKYSSRTQHAILYMNPHKINLDLILELLAYLDKSPQFRNIEGAVLIFLPGL 877

  Fly   472 DEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTI 536
            ..|:...::|.:..:....:.:   ||.:::.|.:..||..|...||..||::||||||||.:||
Human   878 AHIQQLYDLLSNDRRFYSERYK---VIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITI 939

  Fly   537 DNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELE 601
            .::::|||.|..|:|.::..:.|.||:...:|||||.||.|||||...|.|||:||...::..:
Human   940 PDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFM- 1003

  Fly   602 DNTVPEIQRINLGNAVL-MLKA-LGINDLIHFDF----LDPPPHETLVLALEQLYALGALN-HHG 659
            |.:||||.|:.|....| ::|. ||..:    ||    ||||..:.:..|:..|..:||.. :..
Human  1004 DYSVPEILRVPLEELCLHIMKCNLGSPE----DFLSKALDPPQLQVISNAMNLLRKIGACELNEP 1064

  Fly   660 ELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNF 724
            :||.||:.:|..||:..:||||:....:.|.:.:.|:||:::..|. |..|..:...||.|:...
Human  1065 KLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSP-FTTPIGRKDEADLAKSAL 1128

  Fly   725 NHMHGDHLSLLQVYNQW----AETDYSTQ--WCYENFIQYRSMKRARDVREQLVGLMQRV----- 778
            .....|||::...|..|    .|..|.::  :|..||:...|:....||:::|:.|::..
Human  1129 AMADSDHLTIYNAYLGWKKARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSS 1193

  Fly   779 ---------EIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYKTIKHNQTV-----------M 823
                     .........|...::....||.:.:|.::.   :.|::...:.:           .
Human  1194 TTSTSWEGNRASQTLSFQEIALLKAVLVAGLYDNVGKII---YTKSVDVTEKLACIVETAQGKAQ 1255

  Fly   824 IHPNSSLFEELPR--WVLYHELVFTSKEYMRQV--------------IEIESK--------WL-- 862
            :|| ||:..:|..  |:||.|.:..::.|:|:.              ||::.:        |:
Human  1256 VHP-SSVNRDLQTHGWLLYQEKIRYARVYLRETTLITPFPVLLFGGDIEVQHRERLLSIDGWIYF 1319

  Fly   863 ---LEVAPHYYKAKELEDSTNKKM---PKVA 887
               :::|..:.:.:.|.||..:|.   ||::
Human  1320 QAPVKIAVIFKQLRVLIDSVLRKKLENPKMS 1350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	60/287 (21%)
		HrpA	251..>868	CDD:441249	219/773 (28%)
DHX29	NP_061903.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..75
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..226
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..526		7/37 (19%)
		HrpA	571..>1271	CDD:441249	209/716 (29%)
		DEXHc_DHX29	572..754	CDD:350733	74/181 (41%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03068	702..705		2/2 (100%)