DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and dhx38

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_957170.1	Gene:	dhx38 / 393850	ZFINID:	ZDB-GENE-040426-1144	Length:	1258	Species:	Danio rerio

Alignment Length:	921	Identity:	371/921 - (40%)
Similarity:	553/921 - (60%)	Gaps:	82/921 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GKNRKRTASSSSSGEEPDSEEESRLKDLQER-------------DEFASRLKKRDDDRTRNVVDS 54
            ||..||  .....|.:.|.|:|....:..:|             |||.:.|....|:..:.
Zfish   321 GKGEKR--EEGEGGIQFDDEDEKEQWEEDQRQADRDWYMMDEGYDEFHNPLTSSSDEYVKK---- 379

  Fly    55 TGGRRAI--EEATKRLKLE----HEDRDKIVPHLRLQS----RRQYLEKRKDDKVAELEADI--L 107
               |..|  ::..||:..:    :||.::...:..|.|    |.:..|..::|..|.:...:  |
Zfish   380 ---REQILQKQTQKRISAQKRQINEDNERWETNRMLTSGVVQRLEVDEDFEEDNAARVHLLVHNL 441

  Fly   108 DDEYLFDESVLTKREKEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFE 172
            ...:|....|.||:.:.....|....::|....|..:|  ::|:...::.||
Zfish   442 VPPFLDGRIVFTKQPEPVIPVKDATSDMAIISRKGSQL--VRRHREQKERKK------------- 491

  Fly   173 KQPNSEQKKWEAEQLASARFH--FGAK------DAKAEEEYELLLDDQIDF-IQALTLDGSREKS 228
                ::.|.||   ||..:..  .|.:      |:||..|     |.::|: .:....|..:|||
Zfish   492 ----AQHKHWE---LAGTKLGDIMGIQKKEDGGDSKAVGE-----DGKVDYRAEQKFADHMKEKS 544

  Fly   229 SSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAG 293
                 |.:....|:.||.|.|:.||::..::.|:..::::.::|:.||||||||||:.|||.|.|
Zfish   545 -----EASSDFAKKKTLLEQRQYLPIFAVRQQLLNIIRDNNIVIVVGETGSGKTTQLTQYLHEDG 604

  Fly   294 FTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREF 358
            :| ...|:||||||||||||||.||:|||...||.||||:||||||||::|::||||||.|.||.
Zfish   605 YT-SYGMVGCTQPRRVAAMSVAKRVSEEMNSNLGEEVGYAIRFEDCTSEKTMIKYMTDGILLRES 668

  Fly   359 LSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIF 423
            |.|.||..||.:|:||||||:|:||:||||::::...|.:|||:::|||:|::||::||.:.|||
Zfish   669 LRESDLDHYSAVIMDEAHERSLNTDVLFGLLREVVSRRSDLKLIVTSATMDSDKFASFFGNVPIF 733

  Fly   424 RIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRL 488
            .||||.:||||.::|.|:.||::|.....||||.:..:||||:|:.||::||...:.:.:|:..|
Zfish   734 HIPGRTFPVDILFSKTPQEDYVEAAVKQALQIHLSGMVGDILIFMPGQEDIEVTSDQIVERLADL 798

  Fly   489 GSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNF 553
             .....|.|:|:|:.||||:|||||:..|...||.|:||||||||||:|.|::|:|.|:.|...|
Zfish   799 -ENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVVDSGYCKLKVF 862

  Fly   554 NSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVL 618
            |.|.||::|.|.|||:|:|||||||||||.||:|:||||..|:|:|:...|:|||||.||.|.||
Zfish   863 NPRIGMDALQVYPISQANANQRAGRAGRTGPGQCYRLYTQSAFKNEMLTTTIPEIQRTNLANVVL 927

  Fly   619 MLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLA 683
            :||:||:.||:.|.|:||||.:.::.::.||:.||||::.|.||..||.|.|||:||.:.|||:.
Zfish   928 LLKSLGVQDLLLFHFMDPPPEDNMLNSMYQLWILGALDNTGALTPTGRLMVEFPLDPALSKMLIV 992

  Fly   684 SEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYST 748
            |....||.:::.|.:||||.| ||||||.:...:|..|:.|:....|||:.|.||.||...:||:
Zfish   993 SCDMSCSADILIIVSMLSVPS-IFYRPKGREEESDQVREKFSVPESDHLTYLNVYLQWKNNNYSS 1056

  Fly   749 QWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHY 813
            .||.::||..::|::.|:||.||..:|.:.:::::||..:...:||...|.||:..|:|...|.|
Zfish  1057 IWCNDHFIHTKAMRKVREVRAQLKDIMVQQKMNLISCGSDWDVIRKCICAAYFHQAAKLKGIGEY 1121

  Fly   814 KTIKHNQTVMIHPNSSLF--EELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKAKELE 876
            ..::......:||.|:||  ...|.:::|||||.|:||||:.|..::.:||.|:.|.:|..|...
Zfish  1122 VNVRTGMPCHLHPTSALFGMGYTPDYIIYHELVMTTKEYMQCVTAVDGEWLAELGPMFYSIKHAG 1186

  Fly   877 DS--TNKKMPK 885
            .|  .|::..|
Zfish  1187 KSRQENRRRAK 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	315/646 (49%)
		DEXDc	269..408	CDD:238005	87/138 (63%)
		HELICc	491..581	CDD:197757	52/89 (58%)
		HA2	651..735	CDD:214852	39/83 (47%)
		OB_NTP_bind	770..869	CDD:285018	35/100 (35%)
dhx38	NP_957170.1	DEXDc	557..744	CDD:214692	107/187 (57%)
		DEXDc	580..718	CDD:238005	87/138 (63%)
		HELICc	793..892	CDD:197757	56/99 (57%)
		HA2	961..1043	CDD:214852	39/82 (48%)
		OB_NTP_bind	1077..1177	CDD:285018	34/99 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820