Protein Alignment l(2)37Cb and Dhx30

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_006243888.1
• Gene: Dhx30 / 367172
• RGDID: 1308888
• Length: 1222
• Species: Rattus norvegicus
• Alignment Length: 962
• Identity: 270/962 - (28%)
• Similarity: 427/962 - (44%)
• Gaps: 180/962 - (18%)

  Fly    12 SSSSGEEPDSEEESRLKD-LQERDEFASRLKKRDDDRTRNVVDSTGGRRAIEEATKRLKLEHEDR 75
            |.|.|.|.:.:||..|:: ..:..||.|..::...:..|   ||.||           ..|..|.
  Rat   210 SRSLGREEEEDEEEELEEGTIDVTEFLSMTQQDSHNPLR---DSRGG-----------SFEMTDD 260

  Fly    76 DKIVPHLRLQSRRQY-LEKRKDDKVAELEADILDDEYLFD-ESVLTK------------------ 120
            |..:     ::..|: |.|....||.::.......:.|.. .:|.||
  Rat   261 DSAI-----RALTQFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLATLTLLWPCPMTFVA 320

  Fly   121 --REKEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQ---- 179
              |.|.|.|.|...|..    :|.:.|..:.|.|.|........:...|:.|.:::|.:.|
  Rat   321 KGRRKAEAENKAAALAC----KKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEP 381

  Fly   180 --KKWEAEQLASARF--HFGAKDAKAEEEYELLLDDQIDFIQALTLD-GSREKSSSRQP--ELTE 237
              :|.||       |  |:....:....|..|..||    |..|..| |......:.:|  .|:|
  Rat   382 ILRKIEA-------FLSHYPVDSSWISPELRLQSDD----ILPLGKDSGPLSDPITGKPYMPLSE 435

  Fly   238 KERKRLT---LDETRR---------SLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLV 290
            .|..||:   |:..||         .|||.|.::.:::|:::|.|::|.|:||.||||::||.|:
  Rat   436 AEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLL 500

  Fly   291 EAGFTKDKKM---IGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDR-TILKYMTD 351
            |...|:.:..   :..|||||::|:|||.||:.|:|..|...||:.:|.|.....| ..|.:.|.
  Rat   501 ERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFCTV 565

  Fly   352 GTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAF 416
            |.|.|:..|.|.|...|.:|:||.|||.::||.|..|:|.:.|..|.|:|::.|||.|.|:||.:
  Rat   566 GILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRY 630

  Fly   417 FDDAPIFRIPGRRYPVDIFY-----TKAPEADY---------IDACCVS-------VLQIHATQP 460
            |...|:.::||..|||...|     .|..:..|         .|.|.:.       ||.|.|...
  Rat   631 FGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGE 695

  Fly   461 LGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVIL 525
            .|.||.||.|..||:..|:.|.:   .||....:.:::||::|:|...|..||:..|...||::|
  Rat   696 PGGILCFLPGWQEIKGVQQRLQE---ALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVL 757

  Fly   526 ATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRL 590
            ||||||||:|:::|::|:|.|..|:..::.:|.:..|..|.:|:|:..||.|||||...|..:.|
  Rat   758 ATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHL 822

  Fly   591 YTAWAYKHELEDNT---VPEIQRINLGNAVLMLKALGINDLIHF------DFL----DPPPHETL 642
            :.    :..||...   ||||.|..|.|.||..|       ||.      :||    |.|..:.:
  Rat   823 FP----RSRLEKMVPFQVPEILRTPLENLVLQAK-------IHMPEKTAVEFLSKAVDSPNIKAV 876

  Fly   643 VLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLS---VNS 704
            ..|:..|..:|.|:....||.||:|:|....||.:.|.::.:..::|...::.:.:.|:   .:|
  Rat   877 DEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSS 941

  Fly   705 AIFYRPKDKIIHADTARKNFNHMHG-DHLSLLQVYNQWAET----DYSTQWCY--ENFIQYRSMK 762
            ::..|.:     .|..:...:|..| |||:.::....|.|.    |.:::..|  ||.:...|::
  Rat   942 SLQNRAE-----VDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLR 1001

  Fly   763 RARDVREQ---------LVGLMQRVEIDMVSC---LPETVNVRKAATAGYFYHVARLSKG----- 810
            ....:.:|         |||......:....|   ..|...|:....||.:.::.::.:|
  Rat  1002 FIHGLIKQFSENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQ 1066

  Fly   811 GHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWL 862
            |.:|           |||..:......:|.|:....     |:...:.|:||
  Rat  1067 GKFK-----------PNSVTYRTKSGNILLHKSTIN-----REATRLRSRWL 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	69/300 (23%)
		HrpA	251..>868	CDD:441249	206/677 (30%)
Dhx30	XP_006243888.1	HrpA	454..>986	CDD:441249	181/550 (33%)
		OB_NTP_bind	1043..1130	CDD:400182	15/76 (20%)