DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and Dhx32

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001123511.1	Gene:	Dhx32 / 361667	RGDID:	1311740	Length:	751	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	235/753 - (31%)
Similarity:	403/753 - (53%)	Gaps:	62/753 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 EVDEFE-KQPN-SEQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLDGSREKSS 229
            |:||.| :.|| |.:|::..|.|.|         :..:||..|..:|    ::....||.  ..|
  Rat     7 EMDEEELEHPNASPEKRYFPESLDS---------SDGDEEGVLACED----LELNPFDGL--PYS 56

  Fly   230 SRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGF 294
            ||..:|.::          |..||::..|...:.::.::||:::.|::..||::||||:..|...
  Rat    57 SRYYKLLKE----------REELPIWKEKYSFMESLLQNQVVLVSGDSKCGKSSQVPQWCAEYCL 111

  Fly   295 TKDKKMIG--CTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHRE 357
            :...:..|  |||..:..|:.:|.|||:||.|.:|:||||.|.||:|.:..|||:|.||..|.||
  Rat   112 SIHYQHGGVICTQVHKQTAVQLALRVADEMDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQRE 176

  Fly   358 FLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPI 422
            .:|.|.|.||.|:|:|:.|||:|.||:|.||:||:...||||||:|:.:.....:.|:::.:.|:
  Rat   177 MMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIINCSPFLISRLSSYYGNVPL 241

  Fly   423 FRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKR 487
            ..: ..::||::.|....:.|..::....:.:||.:...||::|||..:.:||...|::......
  Rat   242 LEV-RNKHPVEVVYLSGAQKDPFESVVRLIFEIHRSGEQGDVVVFLACEQDIEKTYEIVCQEGSN 305

  Fly   488 LGSKIRELIVIPVYANLPSDMQAKIFEPT-------PPNARKVILATNIAETSLTIDNIIYVIDP 545
            |...:.||:|||:|   |.: :..:|.|.       ..:.|:|:|.|:..|:.:....:.:|||.
  Rat   306 LNPDVGELVVIPLY---PKE-KCSLFRPVDETEKRCQASQRRVVLTTSCGESLIWSHTVRFVIDV 366

  Fly   546 GFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQR 610
            |..::..:|.|....||::.|||::.|..|....|.:..||.|.|||......::......|:|.
  Rat   367 GLERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEEFASKDMRPLKPAEMQE 431

  Fly   611 INLGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDP 675
            .||.:.||.:|.:.|..|...||::.|..|:|:.|||.|..|.||::.|.|::.|..|:|||:||
  Rat   432 ANLTSMVLFMKRVDIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDP 496

  Fly   676 MMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQ 740
            .:.|.:|||.::.|.:||:|||||::..|...:.|......|.|..|.|.|..|||.:|:.:||.
  Rat   497 QLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHVPHGAEEAAVTCWKTFLHPEGDHFTLINIYNA 561

  Fly   741 WAETDYST-------QWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMV----SCLPETVNVRK 794
            :.:|..::       .||:..|:...:::.|..:|.:|:.:::|:|:...    ......:|::|
  Rat   562 YQDTVLNSANEHCVETWCHNCFLSCSALRMADVIRAELLEIIKRIELPYAEPAFGSQENGLNIKK 626

  Fly   795 AATAGYFYHVAR-LSKGGHYKTIKHNQTVMIHPNSS--LFEELPRWVLYHELVFTSKEYMRQVIE 856
            |..:|||..:|| :...|:|..:.|.|...:||.||  :.:::|.|||:|:...:...|:|....
  Rat   627 ALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSSYAITKKMPEWVLFHQFSISENNYIRVTSA 691

  Fly   857 IESKWLLEVAPHYY-------KAKELEDSTNKKMPKVA 887
            :..:..:::.|.||       ::|::....:..:|..|
  Rat   692 VSPELFMQLVPQYYFSNLPPSESKDILQQASGHLPTTA 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	214/667 (32%)
		DEXDc	269..408	CDD:238005	66/140 (47%)
		HELICc	491..581	CDD:197757	27/96 (28%)
		HA2	651..735	CDD:214852	34/83 (41%)
		OB_NTP_bind	770..869	CDD:285018	27/105 (26%)
Dhx32	NP_001123511.1	HrpA	19..687	CDD:224557	222/697 (32%)
		DEXDc	86..202	CDD:238005	52/115 (45%)
		HA2	472..556	CDD:214852	34/83 (41%)
		OB_NTP_bind	597..704	CDD:285018	27/106 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820