Protein Alignment l(2)37Cb and mle

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_476641.1
• Gene: mle / 35523
• FlyBaseID: FBgn0002774
• Length: 1293
• Species: Drosophila melanogaster
• Alignment Length: 1022
• Identity: 264/1022 - (25%)
• Similarity: 422/1022 - (41%)
• Gaps: 209/1022 - (20%)

  Fly     3 GKNRKRTASSSSSGEEPDSEEESRLK----DLQERDEFASRLKKRDDDRTRNVVD---STGGRRA 60
            |..:::......||.:...|....|.    |...|.....|::::.|.......|   :..|...
  Fly   102 GSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWT 166

  Fly    61 IEEATKRLKLEHE-----DRDKIVP----HLR--LQSRRQYL----------EKRKDDKVAELEA 104
            ||.|.:||.:..:     |..|..|    |.|  |.....|:          |...:.|.|....
  Fly   167 IENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSC 231

  Fly   105 DILDDEYLFDESVL------TKREKEER------EYKKQLLNIAKEHEKARELERIQRYNMPQDL 157
            .:.....||..:|:      .|::|:|:      :....|:|...|..|..:|..:...|:..:|
  Fly   232 ALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIEL 296

  Fly   158 KKGERSEYVEVDEFEKQPNSEQKKWEAEQL--ASARFHFGAKDAKAEEEYELL---LDDQIDFIQ 217
            ........|.:...:......:|:.|:..:  |..:.::....|...:|.||.   :||
  Fly   297 DGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDD------ 355

  Fly   218 ALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKT 282
             |::|..|.....||   .:.|.::..  |.|..||:...:.:::.|:.::.|:||.|.||.|||
  Fly   356 -LSMDYERSLRDRRQ---NDNEYRQFL--EFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKT 414

  Fly   283 TQVPQYLV-------EAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDC- 339
            ||:.||::       :.|:..    |..|||||::|:|||.|||.|...:||:.||||:|||..
  Fly   415 TQIAQYILDDYICSGQGGYAN----IYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVF 475

  Fly   340 TSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLIS 404
            ......:.:.|.|.|.|:.  |..|...|.:|:||.|||.:::|.|..:::|:....|:|.:::.
  Fly   476 PRPYGAILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILM 538

  Fly   405 SATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTK--------APEAD------------------ 443
            |||:|..|||.:|...|:..:|||.:||..|:.:        .|.|:
  Fly   539 SATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSED 603

  Fly   444 -------YIDAC-----------------------CVSVLQIHATQ---PLGDILVFLTGQDEIE 475
                   |...|                       .:..|.:|...   | |.|||||.|.:.|.
  Fly   604 KDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIP-GAILVFLPGWNLIF 667

  Fly   476 TCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNII 540
            ...:.|.:  ..:.....:..::|.::.:|.|.|.|:|||.|....|:||:|||||||:|||:|:
  Fly   668 ALMKFLQN--TNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIV 730

  Fly   541 YVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTV 605
            :|||...|:...|.|...:.|...|..||.:..||.|||||..||.||.|.:...:: .||||..
  Fly   731 FVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQ-ALEDNLT 794

  Fly   606 PEIQRINLGNAVLMLKALGINDLIHF--DFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRM 668
            ||:.|..|....|.:|.|.:..:.||  ..|:|||.:.::.|...|..:..|:.:.|||.|||.:
  Fly   795 PEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLL 859

  Fly   669 AEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNF-NHMH---- 728
            |..|::|.:|||::....:.|::.|..:|:..|..|.:|        ..|..::.. ||..
  Fly   860 ARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVF--------SLDIGQRRLANHQKALSG 916

  Fly   729 ---GDHLSLLQVYNQWAE-----TDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRV------- 778
               .||::::.....|..     .....::|....:|..:|....|.::||:.|:|:.
  Fly   917 TKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECM 981

  Fly   779 ---EID--------------MVSCLPETVNV------RKAATAGYFYHVARLSKGGHYKTIKHNQ 820
               |:|              .:.||....|:      ||..|.                   .::
  Fly   982 ISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTT-------------------ESK 1027

  Fly   821 TVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAP 867
            ..::|..|.....|.....|...||..|...|.|   ..|.|..|:|
  Fly  1028 AALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAV---SCKQLSMVSP 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	59/305 (19%)
		HrpA	251..>868	CDD:441249	207/729 (28%)
mle	NP_476641.1	DSRM_DHX9_rpt1	2..70	CDD:380683
		DSRM_DHX9_rpt2	167..241	CDD:380684	16/73 (22%)
		DEXHc_DHX9	326..559	CDD:350730	82/250 (33%)
		HrpA	378..>889	CDD:441249	170/522 (33%)
		OB_NTP_bind	1002..1079	CDD:400182	19/92 (21%)