DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and Rhau

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001260639.1	Gene:	Rhau / 35339	FlyBaseID:	FBgn0032883	Length:	942	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	243/817 - (29%)
Similarity:	383/817 - (46%)	Gaps:	158/817 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 NIAKEHEKARELERIQRYNMPQDLKKGERSEYVE----------------------VDEFEKQP- 175
            |:|::.:|.|                ||.:|..|                      ::::.:.|
  Fly    32 NLARQQKKDR----------------GENAESKEPQIRLGCNVSAPSGVLERVKELMEDYSRAPS 80

  Fly   176 --NSEQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALT------LDGSREKSSSR- 231
              |.:.|.               .|||.::::..||....:...|.|      ||....|...|
  Fly    81 RQNVDDKN---------------VDAKFQQQFRHLLSVNFEEFVAETKERNADLDWVNPKLDERL 130

  Fly   232 -----QPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVE 291
                 |.:|.|..:|||   |.|:.||...:.:|:|.||:|:||::|.|.||.||||||||.|::
  Fly   131 QLELGQRQLEENAKKRL---EARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLD 192

  Fly   292 AGFTK---DKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTS-DRTILKYMTDG 352
            ...::   ....|.||||||::|:::|..|:.|....|||.|||.||.|...: :|..:.|.|.|
  Fly   193 DAISRGCASSCRIICTQPRRISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTG 257

  Fly   353 TLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFF 417
            .|.::..|:|.:.:.||:|:||.|||::.||:|.||:|.|...||:||:::.|||:..:.|..:|
  Fly   258 VLLQQLQSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDYF 322

  Fly   418 DDAPIFRIPGRRYPVDIFY---------------------------------------------- 436
            ::.|:|||.|..:||.:.|
  Fly   323 NNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQKFRDRRPKRDPPERRMKHEAMIEPYLRRIRNSY 387

  Fly   437 -------TKAPEA---DYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSK 491
                   .:.||:   :.||.....|..|...:|.|.|||||.|.|:|.....:|.......|.:
  Fly   388 DSRVLDKLRLPESEGCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQR 452

  Fly   492 IRE-LIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNS 555
            .|: :.|.|:::.:.|..|..:|...|...||||::|.|||||:|||:::|||:.|..|..|::.
  Fly   453 WRDHMAVFPLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDI 517

  Fly   556 RTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLML 620
            .|.::||..|.::||:..||.|||||..||.|:.|::. |.:..::|...|||.|..|.:.:|.|
  Fly   518 ETNIQSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSR-AREDRMDDIPTPEILRSKLESIILSL 581

  Fly   621 KALGINDLIHF--DFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLA 683
            |.|.|:|...|  ..::.|..|.:.:.:|.|..:.||:..|.||.||..:|:.|:||.||||:|.
  Fly   582 KLLHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILM 646

  Fly   684 SEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNF-NHMHGDHLSLLQVYNQWAETDYS 747
            |..:.|.:.:.:.||.||..|. ||.|..|....|..::.. .:|..|||.:......:.::.||
  Fly   647 SALFCCLDPITSAAAALSFKSP-FYSPLGKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYS 710

  Fly   748 ---TQWCYENFIQYRSMKRARDVREQLVGLMQRVE-IDMVSCLPETVN--------VRKAATAGY 800
               ..:||:||:...::::...::.|...|:...: :...:|.....|        :|....||.
  Fly   711 HAERDFCYKNFLSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGAGL 775

  Fly   801 FYHVARLSKGG---------HYKTIKHNQTVMIHPNS 828
            :.::|.|.|..         |.......:.|..||:|
  Fly   776 YPNMAHLRKSRQIKNRVRAIHTMATDDGRRVNFHPSS 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	224/698 (32%)
		DEXDc	269..408	CDD:238005	63/142 (44%)
		HELICc	491..581	CDD:197757	37/90 (41%)
		HA2	651..735	CDD:214852	32/84 (38%)
		OB_NTP_bind	770..869	CDD:285018	15/77 (19%)
Rhau	NP_001260639.1	DEXDc	147..328	CDD:214692	77/183 (42%)
		DEXDc	170..312	CDD:238005	62/141 (44%)
		Helicase_C	411..544	CDD:278689	52/132 (39%)
		HA2	614..696	CDD:214852	31/82 (38%)
		OB_NTP_bind	735..853	CDD:285018	15/78 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468104
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890