DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and CG4901

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster

Alignment Length:	639	Identity:	267/639 - (41%)
Similarity:	400/639 - (62%)	Gaps:	21/639 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 KRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQ 305
            ||.::::.::||||:..:..::..::.:..::|..|||||||||:||:|:.||:.|: .|||.||
  Fly    57 KRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKN-GMIGITQ 120

  Fly   306 PRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVM 370
            ||||||::||.|||:|:...:|:.|||::||||.||..|.::::|||.|.||.:.:..|..|||:
  Fly   121 PRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVI 185

  Fly   371 IIDEAHERTLHTDILFGLVKDIARFR-----PELKLLISSATLDAEKFSAFFDDAPIFRIPGRRY 430
            |:|||||||::.|:|||:|||..:.|     ..||::::|||:|.:.|..:|:...:: :.||.|
  Fly   186 ILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFNCKGMY-LEGRTY 249

  Fly   431 PVDIFYTKAPEADYIDACCVSVLQIHATQPLG-DILVFLTGQDEIETCQEVLHDRVKRLGSKIRE 494
            ||.:.:||....|||....|::..||.|.|.. |:|:|||||:|||:..:.:....|...:...:
  Fly   250 PVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTD 314

  Fly   495 LIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGM 559
            |.|..:||.|....|.:.|.|||.|.|||||||||||||:||..|..|||.||.|:.:||:..|:
  Fly   315 LRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGL 379

  Fly   560 ESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELE---DNTVPEIQRINLGNAVLMLK 621
            :.|..|.||||.|.||||||||.|.|.|:|.||    |.|::   |.|.|||.|.|..:.||.|.
  Fly   380 DVLKSVRISKAQAWQRAGRAGRDADGTCYRAYT----KAEMDSFADATQPEILRTNPTSMVLQLL 440

  Fly   622 ALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGE--LTKLGRRMAEFPVDPMMGKMLLAS 684
            ||.| |..:|||||||..:.|..|.:.|.||||:....:  :|.|||:|.::|:||...|:||.:
  Fly   441 ALDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTA 504

  Fly   685 EKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQ 749
            ..:.|.||::::.::|| :..:|....:|...|..|...|...|||||:||.|:|.:.:::....
  Fly   505 SSFGCMEEILSLVSVLS-SDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKM 568

  Fly   750 WCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARLSKGGHYK 814
            ||::|::..||:..||:||.||..:.:.:.:.:.|. .:...::|....|:|.::|.|.:.|.|.
  Fly   569 WCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSS-DDIEMLKKCILNGFFENIAVLQRDGFYI 632

  Fly   815 TIKHNQTVMIHPNSSLFEEL-PRWVLYHELVFTSKEYMRQVIEIESKWLLEVAP 867
            |...|....|||:|.|..:. |.::|:.|:|.|.:.::|||.||..:|:.||.|
  Fly   633 TASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	266/637 (42%)
		DEXDc	269..408	CDD:238005	74/143 (52%)
		HELICc	491..581	CDD:197757	49/89 (55%)
		HA2	651..735	CDD:214852	30/85 (35%)
		OB_NTP_bind	770..869	CDD:285018	31/99 (31%)
CG4901	NP_001334733.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468078
Domainoid	1	1.000	98	1.000	Domainoid score	I366
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13788at6656
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		otm51353
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.800