DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and CG32533

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001285437.1	Gene:	CG32533 / 32933	FlyBaseID:	FBgn0052533	Length:	1139	Species:	Drosophila melanogaster

Alignment Length:	741	Identity:	240/741 - (32%)
Similarity:	388/741 - (52%)	Gaps:	106/741 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KRKDDKVA----ELEADILDDEYLFDESVLTKREKEEREYKKQLLNIAKEHEKARELERIQRYNM 153
            |:|.|:.|    ..:.::::..:|              ::|.:|:.:.:  .|:|::.|
  Fly     5 KKKADEHASSRRRTQINLIEFSFL--------------DHKAELVGLLQ--AKSRQVGR------ 47

  Fly   154 PQDLKKGERSEYVEVDEFEK------QPNSEQKKWEAEQLASARFHFGAKDAKAEEEYELL---- 208
              .|.:.|...:..|.::|.      ||....:..|||..:...:|.....|...:..|||
  Fly    48 --SLVENEADFWKFVGKYEAMMRSTGQPVLPPRLAEAELSSMQPYHRSKHLALRLDADELLQEAR 110

  Fly   209 --LDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVL 271
              :..|...|..:.||       .||.|..::.||   |.:|:|:||:..|::||..|:...:|:
  Fly   111 DQMQSQFRHILLVYLD-------FRQTEKFQRIRK---LRQTQRNLPIARFRKDLREALDTSRVV 165

  Fly   272 IIEGETGSGKTTQVPQYLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRF 336
            |:.|:||.||:|||||||.:.|:    :.|.||||||:|.:|:..|||.|:....|:.|.:.|||
  Fly   166 IVAGDTGCGKSTQVPQYLYDFGY----RSIACTQPRRLACVSLCKRVAHELLDDYGSRVAFQIRF 226

  Fly   337 EDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKL 401
            |...:..|.:.::|:|.|.|:.....:|..|..:|:||.|||.|..|.|.|:.|.:.|.||:|||
  Fly   227 ERSRTKLTNILFITEGLLLRQLAVAANLDQYDALILDEIHERNLFGDFLLGVTKCLLRARPQLKL 291

  Fly   402 LISSATLDAEKFSAFF--DDAPIFRIPGRRYPVDIFY--------------TKAPEADYID-ACC 449
            ::.|||::.|.|..:|  :.|.:.::|||.:|:.:.|              :|..:.:.|| |..
  Fly   292 ILMSATINVELFHGYFGEEGARLVQVPGRLFPIKLRYLPPPALELKAGQATSKRSQRNRIDPAPF 356

  Fly   450 VSVL----QIHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQA 510
            |.||    |.:.|...||:|:|::|.:|||:..|.:|:    ..::....:|:|:::......|:
  Fly   357 VQVLSLIDQQYPTSERGDVLIFVSGVNEIESVVEAVHE----YATEQTHWLVLPLHSGQAIADQS 417

  Fly   511 KIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQR 575
            |:|:..|...||.|::|||||||||:|.:.:|:|.|..|:.||::....:.|....:||:||:||
  Fly   418 KVFDYAPEGMRKCIVSTNIAETSLTVDGVRFVVDSGKVKEMNFDATCKGQRLKEFWVSKSSADQR 482

  Fly   576 AGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFLDPPPHE 640
            .||||||.||.|||||||..| :..|....|||.|:.|...:|.:.::|:.|:..|.|::.|..|
  Fly   483 KGRAGRTGPGVCFRLYTAEQY-NAFEAYPTPEIYRVPLDTMLLQMVSMGLPDVRAFPFIEAPETE 546

  Fly   641 TL---VLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSV 702
            .:   :|||:|..||..   ..::|.|||.:|..||:..:|||||....:...|:::|:||||||
  Fly   547 RIEQTILALKQHCALSV---EEKITPLGRSLANLPVELSIGKMLLMGSVFPEVEQLLTLAAMLSV 608

  Fly   703 NSAIFYRPKDKIIHAD----TARKNFNHMHGDHLSLLQVYNQWAE----TDYSTQWCYENFIQYR 759
            .:.:..|     .|.|    ..|::....|||..:|:::||.|.:    .|.:.|||....|:.:
  Fly   609 QNPLTNR-----AHTDQRCVRERESLESDHGDLFTLVRLYNVWVQLKMRRDGTRQWCRRLGIEEQ 668

  Fly   760 SMKRARDVREQLVGLMQRVEIDMVSC 785
            .......:|:|    .||:   :.||
  Fly   669 RFYEVTKLRQQ----FQRI---LESC 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	213/596 (36%)
		DEXDc	269..408	CDD:238005	60/138 (43%)
		HELICc	491..581	CDD:197757	35/89 (39%)
		HA2	651..735	CDD:214852	29/87 (33%)
		OB_NTP_bind	770..869	CDD:285018	5/16 (31%)
CG32533	NP_001285437.1	DEXDc	155..327	CDD:214692	71/175 (41%)
		DEXDc	163..298	CDD:238005	60/138 (43%)
		Helicase_C	358..490	CDD:278689	51/135 (38%)
		HA2	560..640	CDD:214852	29/87 (33%)
		OB_NTP_bind	<792..897	CDD:285018
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468111
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840