DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and CG8915

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster

Alignment Length:	932	Identity:	238/932 - (25%)
Similarity:	399/932 - (42%)	Gaps:	193/932 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EEATKRLKLEHEDRDKIVPHL--------RLQSRRQYLEKRKDDKVAELEADILDDEYLFDESVL 118
            |||.||.:.:...:.:.:|..        |:....:...|:|.......:||..|.....||.:|
  Fly     5 EEAVKRGRRQGRKKAQPMPEQAVVLVVNGRVTGGPKGTGKQKTRPGKNAKADAGDKLKSEDEKML 69

  Fly   119 TKREK---EEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQK 180
            .:...   :..|.:|||..:.|....  .:.|:.::...:.:.||.....|   .|..:|.|:
  Fly    70 RQLVDDFLQSCEPEKQLPGLTKAQRS--HVHRLAQHRGLKTVSKGPEENRV---LFISRPQSD-- 127

  Fly   181 KWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLD------GSRE----------KSS 229
                                .:::| :|.:.::|....| ||      |:.|          |.:
  Fly   128 --------------------GQQQY-ILCNTKLDICPPL-LDVLGQMAGNVERRLMNSVGDLKCN 170

  Fly   230 SRQ-------------------PELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEG 275
            .:|                   |..:.:.|   .:...|||||:|..:|.::..::..|||||:|
  Fly   171 KQQYKDIRLPSNFGLVGQRLIPPPQSNRNR---NIQHERRSLPIYKQRESILNVLQRDQVLIIKG 232

  Fly   276 ETGSGKTTQVPQYLVE-AGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDC 339
            .|||||:||:|||::| |...:....|..:||||:||:||:.|:::|.|...|..|||:||....
  Fly   233 ATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQ 297

  Fly   340 TSDRTILKYMTDGTLHREFLSEPDLASY----SVMIIDEAHERTLHTDILFGLVKDIARFRPELK 400
            .|..|:|...|.|.|.|....  |..|:    :.:||||||||.|.||.|....|...:..|.|:
  Fly   298 CSSNTVLMLTTSGCLLRALAM--DKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLR 360

  Fly   401 LLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTK--------------------------- 438
            |::.|||:|.|..|.:|....:..:.||.:.|.|::.:
  Fly   361 LVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPS 425

  Fly   439 -------------APEADYIDACCVSVLQIHATQ-PLGDILVFLTGQDEIETCQEVLHDRVKRLG 489
                         .|:.|  :...||:|::...| ..|.::|:|.|..::.:....|...:.|
  Fly   426 ELLAAYYGGNTIVHPDID--NDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPR-- 486

  Fly   490 SKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFN 554
               .::.:|.:::.:.:..|.|:|...|....|:||:|||.:||:||.:::||||.|.||...::
  Fly   487 ---EQITIILLHSQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYD 548

  Fly   555 SRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDN---------TVPEIQR 610
            |......|.:..||:|.|.||||||||...|.|:|||          ||         |:|||.|
  Fly   549 STIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLY----------DNDRMARMNLYTIPEIMR 603

  Fly   611 INLGNAVLMLKALGINDLIHFDF----LDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEF 671
            ..|....|:.|....:..|. :|    ||.||.:.::.:..:|..||.|:...|:|.||..:||.
  Fly   604 RTLDEICLLTKLAAPDKKIE-NFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAEL 667

  Fly   672 PVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMH-------- 728
            |:...:||.|:.|...:|.:.|:.|||..||....       :::.:..:|:...:.
  Fly   668 PLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPF-------VLNIERGKKSGQQISRVLFAGDG 725

  Fly   729 -GDHLSLLQVYNQWAETDYST--QWCYENFIQYRSMK----RARDVREQLVGLMQRVEID--MVS 784
             .|.|:::::|.::.......  .:|..|||...:|:    .|..:|:.:..:.:..|..  :.|
  Fly   726 MSDSLAVIKLYEEFTNLKRKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLAS 790

  Fly   785 CLPETVN-VRKAATAGYFYHVARLSKGGHYKTIKHNQTVMIHPNSSLF-------EELPRWVLYH 841
            ......| :|.|.|||.:..:|.:.:....:.:.....::....||..       :....|:|:.
  Fly   791 SFNNDTNMIRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFV 855

  Fly   842 ELVFTSKEYMRQVIEIESKWLL 863
            |...|:.    |:..:|...|:
  Fly   856 EKTRTAD----QISSLEHTTLV 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	206/761 (27%)
		DEXDc	269..408	CDD:238005	63/143 (44%)
		HELICc	491..581	CDD:197757	34/89 (38%)
		HA2	651..735	CDD:214852	24/92 (26%)
		OB_NTP_bind	770..869	CDD:285018	18/104 (17%)
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	13/63 (21%)
		DEXDc	214..395	CDD:214692	72/182 (40%)
		DEXDc	226..368	CDD:238005	63/143 (44%)
		HELICc	479..575	CDD:197757	36/100 (36%)
		HA2	648..733	CDD:214852	24/91 (26%)
		OB_NTP_bind	783..884	CDD:285018	18/95 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840