DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and CG1582

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster

Alignment Length:	1075	Identity:	292/1075 - (27%)
Similarity:	458/1075 - (42%)	Gaps:	301/1075 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLKDLQERDEFASRLKKRDDDRTRN-------VVDSTGGRRAIEEATKRLKLEHEDRDKIVPH-L 82
            |...|.::...:...||...|...|       |....|.|...|.....||....|    :|| |
  Fly   267 RFAHLPQQPTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEAPFIYLKTTCHD----IPHEL 327

  Fly    83 RLQSRRQYLEKRKD---DKVAELEA--DIL-DDEYL---FDESVL--TKREKEEREYKKQLLNIA 136
            ||:..|...::.|:   |.:..:.:  |:| .:|.|   .|.|..  .||.....|.....:|..
  Fly   328 RLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDEPAGGGVNPD 392

  Fly   137 KEHEKARELERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQKKWEAEQLASARFHFGAKDAKA 201
            .||.::.:         |....:|:.|         :.....|:..||:...:.|......:.:.
  Fly   393 AEHHQSPK---------PSHYARGQTS---------RNDGGHQRNVEAQTRENRRLLQQFVERRK 439

  Fly   202 EEEYELLLDDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVK 266
            ||.|:.::|.                                     |:.||.:...|.::|.::
  Fly   440 EERYQKIIDG-------------------------------------RKQLPAFAEIERILALIE 467

  Fly   267 EHQVLIIEGETGSGKTTQVPQYLVEAGFTKDKKM----------IGCTQPRRVAAMSVAARVAEE 321
            ...|::|.||||.||:|||||::::..|.:..::          |.||||||::|:.||.|||.|
  Fly   468 SSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAE 532

  Fly   322 MGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILF 386
            ...::|..|||.||.|:..|..|.|.:.|.|.|.|...|:|.|.|.:.:|:||.|||:..:|.|.
  Fly   533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLL 597

  Fly   387 GLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPV------DI---------FY 436
            .::|::.|.|.:||:::.||||:|..||.:|..||:..||||.:||      ||         :.
  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662

  Fly   437 TK---------------------------AP-----------------EADYIDACCVSVLQIHA 457
            ||                           ||                 .|:|....|.|   |:.
  Fly   663 TKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKS---IYL 724

  Fly   458 TQPL------------------------GDILVFLTGQDEIETCQEVLHDRV---KRLGSKIREL 495
            .:|:                        |.||:||.|..||::..:.|.|..   .|.|    :.
  Fly   725 MEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAG----KF 785

  Fly   496 IVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGME 560
            |::|:::.|..:.||.:|:..||..||::|:|||||||:|||:.::|:|.|..|:..|:|...||
  Fly   786 ILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNME 850

  Fly   561 SLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKAL-- 623
            ||.:|.:|:|:|.||.|||||..||.|..|||::.|::.:....||||||:.|...||.:|.|
  Fly   851 SLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQT 915

  Fly   624 --GINDL-IHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASE 685
              ..|.| :..:.|:.|..::::.||.:|..:|||:...:||.||..:|..|||..:||::|...
  Fly   916 FASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGA 980

  Fly   686 KYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAET----DY 746
            .::|.:.::||||.|| |.:.|..|.:|...||..::.|...:.|||::|..|.:|.:.    :|
  Fly   981 IFQCLDSVLTIAACLS-NKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNY 1044

  Fly   747 --STQWCYENFIQYRSMKRARDVREQLVGLMQR---VEIDM------------------------ 782
              |..:..|:|:...:::...|::.|.:.|:..   |.||:
  Fly  1045 AASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGD 1109

  Fly   783 -------VSCLPETVNVRKAATAGYFY--------------HVARL-SKGGHYKTIKHNQTVMIH 825
                   :.|.....|:.|..|....|              |..|. ::|..|        |.||
  Fly  1110 NNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGY--------VKIH 1166

  Fly   826 PNS-----SLFEELPRWVLYHELVFTSKEYMRQ--------------------------VIEIES 859
            |:|     |:|:  ..::::.|.|.||..|:|.                          :..:||
  Fly  1167 PSSVNSQVSVFQ--APFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLES 1229

  Fly   860 KWLLEVAPHYYKAKELEDSTNKKMPKVAGRAEMAQ 894
            .|::      .||.:||            .|||.|
  Fly  1230 GWII------LKAHDLE------------TAEMVQ 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	240/831 (29%)
		DEXDc	269..408	CDD:238005	61/148 (41%)
		HELICc	491..581	CDD:197757	40/89 (45%)
		HA2	651..735	CDD:214852	31/83 (37%)
		OB_NTP_bind	770..869	CDD:285018	30/178 (17%)
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036	1/4 (25%)
		RWD	<284..360	CDD:283440	19/79 (24%)
		HrpA	419..1206	CDD:224557	244/841 (29%)
		DEXDc	471..619	CDD:238005	61/147 (41%)
		HELICc	781..871	CDD:197757	42/93 (45%)
		HA2	948..1029	CDD:214852	31/81 (38%)
		OB_NTP_bind	1070..1212	CDD:285018	27/151 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840