DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)37Cb and Dhx36

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001101148.1	Gene:	Dhx36 / 310461	RGDID:	1308767	Length:	1000	Species:	Rattus norvegicus

Alignment Length:	897	Identity:	273/897 - (30%)
Similarity:	432/897 - (48%)	Gaps:	155/897 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 HLRLQSRRQYLEKRKDDKVAELEADILDDEYLFDESVLTKREKEEREYKKQLLNIAKEHEKAREL 145
            ||:.:....:..|::..|..|.|..        :.:|:...|:.|.:..:.|.::..:::|..|.
  Rat    48 HLKGREIGLWYAKKQTQKNKEAERQ--------ERAVVHMDERREEQIVQLLNSVQAKNDKDSEA 104

  Fly   146 ERIQRYNMPQDLKKGERSEYVEVDEFEKQPNSEQK--KWEAEQLASARFHFGAKD-AKAEEEYEL 207
            :  ..:..|:|...|     .||.. ||:.|||:|  ..|.:.|...:..:...| :..:.:.|.
  Rat   105 Q--ISWFAPEDHGYG-----TEVSS-EKKINSEKKLDNQEKKLLNQEKKTYRITDKSYIDRDSEY 161

  Fly   208 LL---DDQIDFIQALTLDGSREKSSSRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQ 269
            ||   :..:...|.|..|..::|:..|..|          :...|:.||.|..:::|:..:..||
  Rat   162 LLQQNEPNLGLDQQLLEDLQKKKTDPRYIE----------MQRFRKKLPSYGMQKELVNLINNHQ 216

  Fly   270 VLIIEGETGSGKTTQVPQYL----VEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKL--GN 328
            |.:|.||||.||||||.|::    :|.|.....::: ||||||::|:|||.|||.|.....  ||
  Rat   217 VTVISGETGCGKTTQVTQFILDNYIERGIGSACRIV-CTQPRRISAISVAERVAAERAESCGNGN 280

  Fly   329 EVGYSIRFEDCTSDR--TILKYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKD 391
            ..||.||.:.....:  :|| |.|.|.:.:...|:..|:|.|.:::||.|||.|.:|:|..::||
  Rat   281 STGYQIRLQSRLPRKQGSIL-YCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKD 344

  Fly   392 IARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPV------DIF--------------- 435
            :..||.:||:::.||||:|||||.:|.:.|:..|||..:||      ||.
  Rat   345 LLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYFPEQKEHRSQ 409

  Fly   436 ----------------------------YTKAPEADYIDACCVSVLQ------------------ 454
                                        |.|..:..| .|..:.||:
  Rat   410 FKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELQTRY-SASTIDVLEMMDDDKVDLNLIAALIRY 473

  Fly   455 IHATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPN 519
            |...:..|.|||||.|.|.|.|..::|..:|.   .|....::||:::.:|:..|.::|:.|||.
  Rat   474 IVLEEEDGAILVFLPGWDNISTLHDLLMSQVM---FKSDRFLIIPLHSLMPTVNQTQVFKKTPPG 535

  Fly   520 ARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAP 584
            .||:::||||||||:|||:::||||.|..|:.:|:::..:.::....:|||:|.||.|||||..|
  Rat   536 VRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQP 600

  Fly   585 GKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHF--DFLDPPPHETLVLALE 647
            |.|:.||.. .....|:|..:|||.|..|....|.:|.|.:..:.:|  ..:|||..|.:||:::
  Rat   601 GHCYHLYNG-LRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSDEAVVLSIK 664

  Fly   648 QLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRP-- 710
            .|..|.||:...|||.||..:|..||:|.:|||:|....:.|.:.::||||.||.... |..|
  Rat   665 HLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDP-FVIPLG 728

  Fly   711 KDKIIHADTARKNF-NHMHGDHLSLLQVYNQWAETD-----YSTQWCYENFIQYRSMKRARDVR- 768
            |:||  ||..||.. .....|||:::..:..|.|..     |...:|:|.|:...:::...:::
  Rat   729 KEKI--ADARRKELAKETRSDHLTVVNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKG 791

  Fly   769 ---EQLVG---LMQRVEIDMVSCLPE-TVN------VRKAATAGYFYHVA--RLSKGGHYKTIK- 817
               |.|:|   :..|...|     |: .:|      ::....||.:..||  ||:.|...|.:|
  Rat   792 QFAEHLLGAGFVSSRSPKD-----PKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKV 851

  Fly   818 HNQT---VMIHPNSSLFEELP---RWVLYHELVFTSKEYMRQVIEIESKWLL 863
            |.::   |.|||.|...|:..   .|::||..:.||..|:....|:....||
  Rat   852 HTKSDGLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLL 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	242/750 (32%)
		DEXDc	269..408	CDD:238005	61/146 (42%)
		HELICc	491..581	CDD:197757	38/89 (43%)
		HA2	651..735	CDD:214852	35/86 (41%)
		OB_NTP_bind	770..869	CDD:285018	31/113 (27%)
Dhx36	NP_001101148.1	HrpA	187..893	CDD:224557	237/730 (32%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	257..309		21/52 (40%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	326..329		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250\|UniProtKB:Q05B79	379..620		72/245 (29%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	490..549		22/61 (36%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	509..520		2/10 (20%)
		WH domain. /evidence=ECO:0000250\|UniProtKB:Q05B79	621..690		25/68 (37%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	630..689		20/58 (34%)
		OB-fold-like subdomains. /evidence=ECO:0000250\|UniProtKB:Q05B79	833..897		20/63 (32%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	841..852		3/10 (30%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	862..892		10/29 (34%)
		Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..192		35/169 (21%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000269\|PubMed:23651854	1..96		10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		2/4 (50%)
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..43
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	45..97		10/56 (18%)
		DSM (DHX36-specific motif). /evidence=ECO:0000250\|UniProtKB:Q05B79, ECO:0000250\|UniProtKB:Q9H2U1	45..67		4/18 (22%)
		RecA-like domain 1. /evidence=ECO:0000250\|UniProtKB:Q05B79	98..378		101/299 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820