Protein Alignment l(2)37Cb and Dhx36

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001101148.1
• Gene: Dhx36 / 310461
• RGDID: 1308767
• Length: 1000
• Species: Rattus norvegicus
• Alignment Length: 872
• Identity: 266/872 - (30%)
• Similarity: 422/872 - (48%)
• Gaps: 158/872 - (18%)

  Fly   119 TKREKEEREYKKQLLNIAKEHEKARELERIQRYNMPQDLKKGERSEYVEVDEF------------ 171
            |::.||....::.::::    ::.||.:.:|..|..|  .|.::....::..|
  Rat    63 TQKNKEAERQERAVVHM----DERREEQIVQLLNSVQ--AKNDKDSEAQISWFAPEDHGYGTEVS 121

  Fly   172 -EKQPNSEQK--KWEAEQLASARFHFGAKD-AKAEEEYELLL---DDQIDFIQALTLDGSREKSS 229
             ||:.|||:|  ..|.:.|...:..:...| :..:.:.|.||   :..:...|.|..|..::|:.
  Rat   122 SEKKINSEKKLDNQEKKLLNQEKKTYRITDKSYIDRDSEYLLQQNEPNLGLDQQLLEDLQKKKTD 186

  Fly   230 SRQPELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYL----V 290
            .|..|          :...|:.||.|..:::|:..:..|||.:|.||||.||||||.|::    :
  Rat   187 PRYIE----------MQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYI 241

  Fly   291 EAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKL--GNEVGYSIRFEDCTSDR--TILKYMTD 351
            |.|.....::: ||||||::|:|||.|||.|.....  ||..||.||.:.....:  :|| |.|.
  Rat   242 ERGIGSACRIV-CTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSIL-YCTT 304

  Fly   352 GTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAF 416
            |.:.:...|:..|:|.|.:::||.|||.|.:|:|..::||:..||.:||:::.||||:|||||.:
  Rat   305 GIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEY 369

  Fly   417 FDDAPIFRIPGRRYPV------DIF---------------------------------------- 435
            |.:.|:..|||..:||      ||.
  Rat   370 FGNCPMIHIPGFTFPVVEYLLEDIIEKIRYFPEQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKER 434

  Fly   436 ---YTKAPEADYIDACCVSVLQ------------------IHATQPLGDILVFLTGQDEIETCQE 479
               |.|..:..| .|..:.||:                  |...:..|.|||||.|.|.|.|..:
  Rat   435 WPAYIKELQTRY-SASTIDVLEMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHD 498

  Fly   480 VLHDRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVID 544
            :|..:|.   .|....::||:::.:|:..|.::|:.|||..||:::||||||||:|||:::||||
  Rat   499 LLMSQVM---FKSDRFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVID 560

  Fly   545 PGFAKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQ 609
            .|..|:.:|:::..:.::....:|||:|.||.|||||..||.|:.||.. .....|:|..:|||.
  Rat   561 GGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNG-LRASLLDDYQLPEIL 624

  Fly   610 RINLGNAVLMLKALGINDLIHF--DFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFP 672
            |..|....|.:|.|.:..:.:|  ..:|||..|.:||:::.|..|.||:...|||.||..:|..|
  Rat   625 RTPLEELCLQIKILRLGGIAYFLSRLMDPPSDEAVVLSIKHLMELSALDKQEELTPLGVHLARLP 689

  Fly   673 VDPMMGKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRP--KDKIIHADTARKNF-NHMHGDHLSL 734
            |:|.:|||:|....:.|.:.::||||.||.... |..|  |:||  ||..||.. .....|||::
  Rat   690 VEPHIGKMILFGALFCCLDPVLTIAASLSFKDP-FVIPLGKEKI--ADARRKELAKETRSDHLTV 751

  Fly   735 LQVYNQWAETD-----YSTQWCYENFIQYRSMKRARDVR----EQLVG---LMQRVEIDMVSCLP 787
            :..:..|.|..     |...:|:|.|:...:::...:::    |.|:|   :..|...|     |
  Rat   752 VNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRSPKD-----P 811

  Fly   788 E-TVN------VRKAATAGYFYHVA--RLSKGGHYKTIK-HNQT---VMIHPNSSLFEELP---R 836
            : .:|      ::....||.:..||  ||:.|...|.:| |.::   |.|||.|...|:..   .
  Rat   812 KANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSDGLVSIHPKSVNVEQTDFHYN 876

  Fly   837 WVLYHELVFTSKEYMRQVIEIESKWLL 863
            |::||..:.||..|:....|:....||
  Rat   877 WLIYHLKMRTSSIYLYDCTEVSPYCLL 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	33/166 (20%)
		HrpA	251..>868	CDD:441249	237/721 (33%)
Dhx36	NP_001101148.1	Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1	1..192		28/144 (19%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000269|PubMed:23651854	1..96		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1	1..43
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1	45..97		8/39 (21%)
		DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1	45..67		1/3 (33%)
		RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79	98..378		95/291 (33%)
		DEXHc_DHX36	199..378	CDD:350739	75/180 (42%)
		HrpA	207..>768	CDD:441249	198/570 (35%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	257..309		21/52 (40%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	326..329		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79	379..620		72/245 (29%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	490..549		22/61 (36%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1	509..520		2/10 (20%)
		WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79	621..690		25/68 (37%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	630..689		20/58 (34%)
		OB_NTP_bind	823..909	CDD:400182	25/81 (31%)
		OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79	833..897		20/63 (32%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	841..852		3/10 (30%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	862..892		10/29 (34%)