DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)37Cb and Ythdc2

DIOPT Version :9

Sequence 1:	NP_609946.1	Gene:	l(2)37Cb / 35192	FlyBaseID:	FBgn0086444	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_038953178.1	Gene:	Ythdc2 / 307446	RGDID:	1563192	Length:	1434	Species:	Rattus norvegicus

Alignment Length:	1091	Identity:	263/1091 - (24%)
Similarity:	433/1091 - (39%)	Gaps:	343/1091 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 LDDEYLFDESVLTKR----EKEEREYKKQLLNIAKE--HEKARELERIQRYNMPQDLKKGE-RSE 164
            :|:|.....::..:|    ::.|.|:...|.:..:.  |..::.|..:.:       .||: .:.
  Rat    45 IDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSK-------SKGKGANR 102

  Fly   165 YVEVDEFEKQPNSEQKKWEAEQLASARFHFGAKDA----------KAEEEYELLLDDQIDFIQAL 219
            |:.|   :|:..||    .|..:.:.......|.|          ..:|..|||...:...:.|:
  Rat   103 YLTV---KKKDGSE----TAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAV 160

  Fly   220 TLDGSRE--KSSSRQ----PELTEKERKRLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETG 278
            ..: :||  |:|.|.    |::..| |.....|..|:||||:..:|:::..:||::|::|.||||
  Rat   161 EAE-NREMSKTSGRLNNGIPQVPVK-RGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETG 223

  Fly   279 SGKTTQVPQYLVEAGFTKD-KKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSD 342
            ||||||:||:|::..|... ...|.||||||:||::||.|||.|...::|..:||.||.|...|.
  Rat   224 SGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSP 288

  Fly   343 RTILKYMTDGTLHREFLS-EPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSA 406
            :|:|.:.|:|.|.|..:: :..|::.:.:|:||.|||...:|.|...::|:.:..|.|||::|||
  Rat   289 KTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSA 353

  Fly   407 TLDAEKFSAFFDDAPIFRIPGRRYPV--------------------------------------- 432
            .||...|..:|...|:..|.||.:.|
  Rat   354 ALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEW 418

  Fly   433 --------------------------------DIFYTKAPEADY----------IDAC------- 448
                                            |..:::..|.|.          :|||
  Rat   419 YSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLH 483

  Fly   449 ----------------------------------------------------------------- 448

  Rat   484 KDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMAL 548

  Fly   449 ----------CVSVLQIHATQ-------------------------------------------- 459
                      .|.:|:.::..
  Rat   549 DWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLI 613

  Fly   460 -----------PLGDILVFLTGQDEIETCQEVLHDRV----KRLGSKIRELIVIPVYANLPSDMQ 509
                       ..|.||:||.|.|||..    |.||:    ||.........|..:::|:.:..|
  Rat   614 MHLLYNICHSCDAGAILIFLPGYDEIVG----LRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQ 674

  Fly   510 AKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLMVVPISKASANQ 574
            .|:.:..|...||:||:|||||||:|::::::|||.|..|:.:|::...:..|.:|.||||||.|
  Rat   675 KKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQ 739

  Fly   575 RAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGINDLIHFDFL----D 635
            |.|||||..||.||||::...:::.||..| ||:.|:.|....|..|.|...:....|||    :
  Rat   740 RKGRAGRCRPGICFRLFSRLRFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNCTIADFLMKAPE 803

  Fly   636 PPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKCSEEMVTIAAML 700
            |||...:..|::.|..:.|::...:||:||..:|:.||:|.:|||:|.:...||.:.::|||..|
  Rat   804 PPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTL 868

  Fly   701 SVNSAIFYRPKDKII---------HADTARKNFN-HMHGDHLSLLQVYNQW--AETD-YSTQWCY 752
            :      ||  |..:         .|...||.|. ....||::||:.:..|  |.:| :...:|.
  Rat   869 A------YR--DPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCE 925

  Fly   753 ENFIQYRSMKRARDVREQLVGLMQRV---------EIDMVSCLPETVNVRKAA-TAGYFYHVARL 807
            :||:...:|:....:|.||:|.::..         :|..|:...|...|.||| .||.:.::..:
  Rat   926 KNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHV 990

  Fly   808 SKGGHYKTIKHNQTVMIHPNSSL----FEELP--------------RWVLYHE------------ 842
            .:.....|....:.|..||.|.|    ::::|              .|::|.|
  Rat   991 DRENVVLTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRC 1055

  Fly   843 ---------LVFTSKEYM-RQVIEIESKWLLEVAPHYYKAKELEDSTNKKM 883
                     |||.....: ...::..|.:..:..|:.....|:||.|...:
  Rat  1056 CSAVTPVTVLVFCGPARLTSNALQEPSSFRADGIPNDSSDSEMEDRTTANL 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	HrpA	222..867	CDD:224557	235/941 (25%)
		DEXDc	269..408	CDD:238005	61/140 (44%)
		HELICc	491..581	CDD:197757	36/89 (40%)
		HA2	651..735	CDD:214852	28/93 (30%)
		OB_NTP_bind	770..869	CDD:285018	27/148 (18%)
Ythdc2	XP_038953178.1	R3H_DEXH_helicase	50..108	CDD:100077	10/67 (15%)
		HrpA	193..>1020	CDD:224557	218/839 (26%)
		DEXHc_YTHDC2	197..372	CDD:350745	72/174 (41%)
		ANK repeat	509..541	CDD:293786	0/31 (0%)
		ANK repeat	543..571	CDD:293786	2/27 (7%)
		OB_NTP_bind	975..1070	CDD:400182	18/94 (19%)
		YTH	1293..1422	CDD:410979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000