Protein Alignment l(2)37Cb and Tdrd9

DIOPT Version :10

• Sequence 1: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_017450003.1
• Gene: Tdrd9 / 299343
• RGDID: 1306942
• Length: 1396
• Species: Rattus norvegicus
• Alignment Length: 699
• Identity: 202/699 - (28%)
• Similarity: 327/699 - (46%)
• Gaps: 109/699 - (15%)

  Fly   167 EVDEFEKQPN-----SEQKKWEAEQLASARFHFGAKDAKAEEEYELLLDDQIDFIQALTLD--GS 224
            ||...|:.|:     ..|...:|..||.....||...::...|.|.:  ::...::|..||  |.
  Rat    40 EVQRSEEVPSEAPTAQAQDPVKATALARPASAFGRSLSQRSSEVEYI--NKYRQLEAQELDIYGQ 102

  Fly   225 REKSSS---RQPELTEKERKRLTLDETRRSLPVYPF---KEDLIAAVKEHQVLIIEGETGSGKTT 283
            .:..|.   |.|  ..|......:.||....|..|.   ||::|:.::.:.|:||.|.|||||:|
  Rat   103 DQPPSGPGLRSP--LAKISNVACIPETTYKYPDLPINRCKEEVISLIESNSVVIIHGATGSGKST 165

  Fly   284 QVPQYLVEAGFTKDKKM--IGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTIL 346
            |:|||::: .:|:....  |..||||::.|.|:|..:::|....||..|||.:..|...::.|.|
  Rat   166 QLPQYVLD-HYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKTATEDTRL 229

  Fly   347 KYMTDGTLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPE-LKLLISSATLDA 410
            .|||.|.|.::.:|...|..::.:.|||.||||...|.|..:|:.:.|.... :|:::.|||::.
  Rat   230 IYMTTGVLLQKIVSAKSLMEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVILMSATINC 294

  Fly   411 EKFSAFF--------DDAPIFRIPGRRYPVDIFYTKAPEADY-----------------IDACCV 450
            ::|:.:|        :.|.:|.:.|:.:.::.:|.......|                 :....|
  Rat   295 KQFADYFAVPVQNKMNPAYVFEVEGKPHTIEQYYLNDLGHIYHSGLPPYRLEEPVITKDVYEVAV 359

  Fly   451 SVLQI-----------------HATQPLGDILVFLTGQDEIETCQEVLHDRVKRLGSKIRELIVI 498
            |::|:                 ........:||||.|..||....|:|.:.:.      :.|.|.
  Rat   360 SLIQMFDDLDMKESGNKTWSGAQFVSERSSVLVFLPGLGEINYMHELLTNMIH------KRLQVY 418

  Fly   499 PVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGMESLM 563
            |:::::..:.|..:|....|..||:||:|||||:|:|:.::.||||....:....:..|..:||.
  Rat   419 PLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLR 483

  Fly   564 VVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALGIND- 627
            :...||.|.:||.|||||.:.|.|:||.....:...:.|:.|||:.|..||:.||.:|.|.:.:
  Rat   484 LSWASKTSCDQRKGRAGRVSKGYCYRLIHRDFWDSAIPDHVVPEMLRCPLGSTVLKVKLLDMGEP 548

  Fly   628 -LIHFDFLDPP---PHETLVLALEQLYALGALN-------HHGELTKLGRRMAEFPVDPMMGKML 681
             .:....|.||   ..|..:|.|:::.||....       |.||||.|||.:|:.||...:||::
  Rat   549 RALLATALSPPSLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLI 613

  Fly   682 LASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHG----DHLSLLQVYNQWA 742
            :....:.|.:|.:.|||.||:.: .|..|..:  |.|..| |..|..|    |.|:|::.:..|.
  Rat   614 VLGHVFGCLDECLIIAAALSLKN-FFTMPFRQ--HLDGYR-NKVHFSGSSRSDCLALVEAFRAWQ 674

  Fly   743 -------------ETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRV 778
                         |.|    |...|:||   :||.|:|.|....|..|:
  Rat   675 ACRQRGELRHPKDELD----WGRLNYIQ---IKRIREVAELYEELKNRI 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	27/112 (24%)
		HrpA	251..>868	CDD:441249	180/605 (30%)
Tdrd9	XP_017450003.1	HrpA	132..>707	CDD:441249	177/592 (30%)
		DEAD-like_helicase_N	134..317	CDD:475120	62/183 (34%)
		Tudor_TDRD9	919..1018	CDD:410502